Erin Major¹*, Erin G Sieck², Michelle G Pedler¹ and Robert W Enzenauer^1,2

¹Department of Pediatric Ophthalmology, Children’s Hospital of Colorado, Aurora, USA
²Department of Ophthalmology, University of Colorado School of Medicine, Department of Ophthalmology, Aurora, USA

*Corresponding Author: Erin Major, Department of Pediatric Ophthalmology, Children’s Hospital of Colorado, Aurora, USA.

Received: July 20, 2023; Published: July 27, 2023

Abstract

Significance: To determine if uncorrected refractive error influences the results of an electroretinogram (ERG).

Purpose: To investigate how induced myopia and hyperopia alter electroretinogram (ERG) results in a rabbit model.

Methods: The ERG’s were measured in New Zealand white rabbits (n = 10) after dark adaptation. The ERG’s were then repeated using a high-plus contact lens to simulate myopia (-10D and -20D) and high-minus contact lenses to simulate hyperopia (+10D and +20D).

Results: Induced refractive error with contact lenses showed a significant reduction in scotopic ERG amplitudes in myopia -10D (P = .0479), and hyperopia +10D (P = .0206) and +20D (P = .0487). There was no significant statistical difference in the implicate time or a/b wave ratios between plano and induced myopia or hyperopia.

Conclusions: There was a significant decrease in ERG amplitudes after induced refractive error in our animal study. Corrective refraction may need to be given to patients prior to ERG or a corrective calculation could be developed to provide a more accurate interpretation of ERG’s performed in patients with significant myopia or hyperopia. ERGs performed on highly myopic and hyperopic patients should be interpreted with caution and our study provides credence to disparities seen in this patient population.

 Keywords: Myopia; Amplitudes; Electroretinogram

References

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Citation

Citation: Erin Major., et al. “Induced Myopia and Hyperopia Effect on a Normal Electroretinogram".Acta Scientific Ophthalmology 6.8 (2023): 24-29.

Copyright

Copyright: © 2023 Erin Major., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.