Sources of Food with Insulin-Secreting, Insulin-Sensitizing, and Insulin-Mimetic Properties
Pérez Sira EE1* and Schroeder F2
1Instituto de Ciencia y Tecnología de Alimentos, Facultad de Ciencias Universidad Central de Venezuela, Caracas Venezuela
2Burrell College of Osteopathic Medicine. Las Cruces, New Mexico, USA
*Corresponding Author: Pérez Sira EE, Instituto de Ciencia y Tecnología de Alimentos, Facultad de Ciencias Universidad Central de Venezuela, Caracas Venezuela.
Received:
April 02, 2025; Published: April 27, 2025
Abstract
This review provides a glance at the mechanisms of diabetes, emphasizing Diabetes Mellitus type 2 and its relationship to nutrition. It also discusses several studies on sources that have insulinotropic properties. Besides it is described several species of plants and some of their phytonutrients, which are isolated or present in the extract, could be used in the development of food for diets for patients with Diabetes. Numerous studies have demonstrated that antidiabetic phytonutrients are highly effective against Diabetes patients and are almost completely without side effects. In conclusion, diabetic patients must receive medical nutrition therapy using selecting foods to meet their individual nutritional needs with insulinotropic properties. Fortunately, nature provides several sources of foods that can be useful for the implementation of these diets that must be certified institutionally through scientific confirmation. A lack of interest in the importance of herbal medicine is a primary factor contributing to unsolved health concerns. Medical communities, including nutritionists and food technologists, must take the topic into their own hands to prevent or control illness. Furthermore, there is a lack of research on the studies of these sources with clinical trials; therefore, researchers in the area must take it under control because this topic represents food and state security.ated with this disorder.
Keywords:Diabetes Mellitus; Functional Food; Insulinotropic Agents; Herbal Medicine; Medicinal Plants; Phytochemical; Phytonutrients
References
- Feher J. “The Endocrine Pancreas and Control of Blood Glucose. In: Feher J.ed, Quantitative Human Physiology, Academic Press (2012): 799-809.
- Giri B., et al. “Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity”. Biomedicine and Pharmacotherapy 107 (2018): 306-328.
- Craig ME., et al. “Definition, epidemiology and classification of diabetes in children and adolescents”. Pediatric Diabetes12 (2010): 3-12.
- Goldenberg R and Punthakee Z. “Classification and diagnosis of Diabetes, prediabetes and metabolic syndrome”. Canadian Journal of Diabetes 37 (2013): S8eS11.
- Goldenberg R Punthakee Z. “Definition, classification and diagnosis of diabetes, prediabetes and metabolic síndrome”. Canadian Journal of Diabetes1 (2013): S8-11.
- “American Diabetes Association Diagnosis and classification of Diabetes Mellitus”. Diabetes Care 37.1 (2014): S81-S90.
- Shivashankar M and Mani T. “A brief overview of diabetes”. International Journal of Pharmacy and Pharmaceutical Sciences4 (2011): 22-27.
- Delli AJ and Lernmark A. “Chapter 41 - Autoimmune (Type 1) Diabetes, In: The Autoimmune Diseases 5th Edition, Academic Press (2014): 575-586.
- Shouip HA. “Diabetes mellitus: Sinai University”. Faculty of Pharmacy and Pharmacology Industries (2014).
- Burrack AL., et al. “T-Cell-Mediated beta cell destruction: Autoimmunity and alloimmunity in the context of Type 1 Diabetes”. Frontiers in Endocrinology (Lausanne) 8 (2017): 343.
- Chon S and Gautier J-F. “An Update on the Effect of Incretin-Based Therapies on β-Cell Function and Mass”. Diabetes and Metabolism Journal2 (2016): 99.
- Lu X., et al. “Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy”. Signal Transduction and Targeted Therapy1 (2024): 262.
- Buchanan TA and Xiang AH. “Gestational Diabetes Mellitus”. The Journal of Clinical Investigation 3 (2005): 485-491.
- Szablewski L. “Chapter 12. Glucose homeostasis-mechanism and defects, In ed. by Rigobelo E., Diabetes”. Damages and Treatments (2011): 227-252.
- Mann E., et al. “Secretion of insulin in response to diet and hormones”. Pancreapedia (2020): 1-17.
- Schmitz O., et al. “On high-frequency insulin oscillations”. Ageing Research Reviews 7 (2008): 301-305.
- Quan Y., et al. “Current understanding of KATP channels in neonatal diseases: focus on insulin secretion disorders”. Acta Pharmacologica Sinica 32 (2011): 765-780.
- González-Mujica F. “Insulina. Estructura, síntesis, secreción, depuración y degradación (Revisión)”. Vitae (2017).
- Díaz Hernández DP and Burgos Herrera LC. “Cómo se transporta la glucosa a través de la membrana celular?” IATREIA3 (2002): 179-189.
- Röhrborn D., et al. “DPP4 in diabetes”. Frontiers in Immunology 6.8 (2015):
- Freeman AM, Acevedo LA, Pennings N. “Insulin Resistance”. [Updated 2025 march 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing (2023).
- Awuku M. “Chapter Understanding insulin: A primer. Beta Cells in Health and Disease Irfan S., Anwar H., Ed.
- Wilcox G. “Insulin and insulin resistance”. Clinical Biochemist Reviews 26 (2005): 19-23.
- Albratty M and Halaw M. “Antidiabetic phytoconstituents: from traditional medicine to modern drug Discovery”. Pharmacognosy Magazine4 (2024): 1048–1060.
- Lee S-H., et al. “Insulin Resistance: From mechanisms to therapeutic Strategies”. Diabetes and Metabolism Journal 46 (2022): 15-37.
- Irwin DM and Prentice KJ. “Incretin hormones and the expanding families of glucagon‐like sequences and their receptors Diabetes”. Obesity and Metabolism (2011).
- Kazakos “Incretin effect: GLP-1, GIP, DPP4”. Diabetes Research and Clinical Practice 93.1 (2011): S32-S36.
- Figueredo EA., et al. “Inhibidores de la dipeptidil peptidasa 4 y una nueva estrategia farmacológica en la diabetes mellitus tipo 2”. Revista Cubana de Medicina3 (2016): 239-256.
- FDA US Food and Drug Administration. Comunicado de la FDA in (2015).
- “Tradicional Medicine (2023).
- Silveira Rabelo AC., et al. “A review of biological and pharmacological activities of Baccharis trimera”. Chemico-Biological Interactions 296 (2018): 65-75.
- Frank J., et al. “Terms and nomenclature used for plant-derived components in nutrition and related research: efforts toward harmonization”. Nutrition Reviews6 (2020): 451-458.
- Chuengsamarn S., et al. “Curcumin extract for prevention of type 2 diabetes”. Diabetes Care11 (2012): 2121-2127.
- Balekari U and Veeresham C. “Insulinotropic agents from medicinal plants”. Journal of Pharmaceutical Sciences and Emerging Drugs 2 (2014): 1.
- Malinska H., et al. “A plant-based meal reduces postprandial oxidative and dicarbonyl stress in men with diabetes or obesity compared with an energy- and macronutrient-matched conventional meal in a randomized crossover study”. Nutrition and Metabolism (Lond) 84 (2021).
- Oliveira, et al. “Sugar-Free dark chocolate consumption results in lower blood glucose in adults with Diabetes”. Nutrition and Metabolic Insights 15 (2022): 11786388221076962.
- Yonemoto E., et al. “Cocoa extract induces browning of white adipocytes and improves glucose intolerance in mice fed a high-fat diet”. Bioscience, Biotechnology, and Biochemistry 88 (10): 1188–1198.
- Rauf A., et al. “Health perspectives of a bioactive compound curcumin: A review”. Trends in Food Science and Technology 74 (2018): 33-45.
- Dias Soares JM., et al. “Influence of flavonoids on mechanism of modulation of insulin secretion”. Pharmacognosy Magazine52 (2017): 639-646.
- Ito-Nagahata T., et al. “Stilbene analogs of resveratrol improve insulin resistance through activation of AMPK”. Bioscience, Biotechnology, and Biochemistry6 (2013): 1229-1235.
- Zakłos-Szyda M., et al. “Antidiabetic effect of polyphenolic extracts from selected edible plants as α-amylase, α -glucosidase and PTP1B inhibitors, and β pancreatic cells cytoprotective agents - a comparative study”. Current Topics in Medicinal Chemistry 23 (2015): 2431-2444.
- Kazeem MI and Davies TC. “Anti-diabetic functional foods as sources of insulin secreting, insulin sensitizing and insulin mimetic agents”. Journal of Functional Foods 20 (2016): 122-138.
- Nazaruk J., et al. “The role of triterpenes in the management of Diabetes Mellitus and its complications”. Phytochemistry Reviews4 (2015): 675-690.
- Xu F., et al. “Beneficial health effects of lupenone triterpene: A review”. Biomedicine and Pharmacotherapy 103 (2018): 198-203.
- Hussain N., et al. “New iridoids from Lyonia ovalifolia and their anti-hyperglycemic effects in mice pancreatic islets”. Fitoterapia 131 (2018): 168-173.
- Tundis R., et al. “Biological and pharmacological activities of iridoids: recent developments”. Mini-Review in Medicinal Chemistry4 (2008): 399-420.
- Kazeem M., et al. “Functional foods with dipeptidyl peptidase-4 inhibitory potential and management of type 2 diabetes: A review”. Food Frontiers 2 (2021): 153-162.
- Andersen ES., et al. “Do we know the true mechanism of action of the DPP-4 inhibitors?” Diabetes, Obesity and Metabolism1 (2018): 34-41.
- Saltfiel AR and Kahn CR. “Insulin signaling and the regulation of glucose and lipid metabolism”. Nature 6865 (2001): 799-806.
- García-Vicente S., et al. “Oral insulin-mimetic compounds that act independently of insulin”. Diabetes2 (2007): 486-493.
- Komakula SB., et al. “A novel quantitative assay for analysis of GLUT4 translocation using high content screening”. Biomedicine and Pharmacotherapy 13 (2021):
- Martel J., et al. “Anti-obesogenic and anti-diabetic effects of plants and mushrooms”. Nature Review Endocrinology3 (2017): 149-160.
- Haselgrübler R., et al. “Insulin mimetic properties of extracts prepared from Bellis perennis”. Molecules10 (2018): 2605.
- Neuhauser C., et al. “Insulin-Mimetic activity of herbal extracts identified with large-scale total internal reflection Fluorescence Microscopy”. Nutrients14 (2024): 2182.
- Zangeneh F., et al. “Insulin sensitizers”. Mayo Clin Proceedings 78 (2003): 471-479.
- Colca JR. “The TZD insulin sensitizer clue provides a new route into Diabetes drug discovery”. Expert Opinion on Drug Discovery 12 (2003): 1259-1270.
- Robertson MD., et al. “Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism”. American Journal of Clinical Nutrition 3 (2005): 559-567.
- Lin Y., et al. “Regulation of insulin sensitivity by phosphorus. 2018”. Diabetes Dynamic Approaches to Improve Glycemic Control and Primary Diabetes Care. AAD1 (2018).
- Castellano JM., et al. “Biochemical basis of the anti-diabetic activity of oleanolic acid and related pentacyclic triterpenes”. Diabetes 62 (2013): 1791-
- Bhattacharya J. “Assessment of vitamin D status and its association with insulin resistance among type 2 diabetic subjects”. International Journal of Research in Medical Sciences IJRMS 12 (2018): 3825-3831.
- Lontchi-Yimagou E., et al. “Insulin sensitising effects of vitamin D mediated through reduced adipose tissue inflammation and fibrosis. Diabetes Dynamic Approaches to Improve Glycemic Control and Primary Diabetes Care. AAD1 (2018).
- Belenchia AM., et al. “Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: A randomized controlled trial”. American Journal of Clinical Nutrition 4 (2013): 774-781.
- Katz DL., et al. “Cocoa and chocolate in human health and disease”. Antioxidants and Redox Signaling 10 (2011): 2779-811.j
- Mellor D and Naumovski N. “Effect of cocoa in diabetes: The potential of the pancreas and liver as key target organs, more than an antioxidant effect?” International Journal of Food Science and Technology 4 (2016): 829-841.
- Ferreira Martins T., et al. “Cocoa Flavanols protect human endothelial cells from oxidative stress”. Plant Foods for Human Nutrition 5 (2020): 161-168.v
- Patyra A., et al. “Pharmacological and phytochemical insights on the pancreatic β-cell modulation by Angelica L. roots”. Journal of Ethnopharmacology 329 (2024): 118133.
- Pérez Sira EE and Schroeder F. “Intake of Bone Extract as Control and Prevention of Diabetes Mellitus Type II: A Glance. Diabetes Actual”. Under Review (2025).
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