Beatriz Estella López-Marín*, Paula Andrea Rivera Medina and Gloria C Deossa Restrepo

School of Nutrition and Dietetics-University of Antioquia, Medellín, Antioquia

*Corresponding Author: Beatriz Estella López-Marín, School of Nutrition and Dietetics-University of Antioquia, Medellín, Antioquia.

Received: March 11, 2025; Published: March 25, 2025

Abstract

Introduction: long-chain polyunsaturated fatty acids (G.A) are of importance for the infant and that they reach mature breast milk (LMM) through blood circulation, from the digestion and absorption of ingested fat and/or from the mobilization of the mother's fat reserves; research affirms that most of the G.A. in blood plasma are of dietary origin, thus indicating that the content of these in the LMM is dependent on the amount circulating in the plasma.

Objectives: To evaluate the profile of G at the serum level and its influence on G content in the LMM.

Materials and Methods: The sample consisted of 50 women with at least 30 days of breastfeeding. 30 mL of LMM, collected from both breasts, were extracted from 7 to 9 a.m. by hand extraction and 2 mL of blood. The fatty acid profile for LM and plasma was done by gas chromatography, internal standard was used, and a reference standard (37-component FAME Mix) was used for the identification of FAs.

Results: Minimal correlation was found, such as linoleic acid, cis-docosahexaenoic acid and cis-eicosapentaenoic acid; low correlation with palmitoleic acid and in the rest of the A.G there is no correlation. Conclusions. There was no significant correlation between plasma G.A. content and LMM, its content seems to be mainly given by the nutritional needs of the baby and is directly related to a physiological process of the mammary gland.

Keywords: Breast Milk; Fatty Acids; Mammary Gland; Breastfeeding Woman; Baby; Plasma

References

1. World of the O and Genebra S. “Global Strategy for Infant and Young Child Feeding” (2003).
2. Innis SM. “Impact of maternal diet on human milk composition and neurological development of infants”. The American Journal of Clinical Nutrition3 (2014): 734S-741S.
3. “DIETARY GUIDELINES: for pregnant women and breastfeeding mothers”. Food guides for Pregnant Women and Lact Mothers (1999): 44.
4. García-López DR. “Composition and immunology of human milk”. Acta Pediátrica de México44 (2011): 223-230.
5. Cruz-Hernandez C., et al. “Direct quantification of fatty acids in human milk by gas chromatography”. Journal of Chromatography A 1284 (203): 174-179.
6. Jensen RG. “The lipidds in human milk”. Progress in Lipid Research 35 (1996).
7. Vega PS., et al. “The importance of fatty acids in breast milk and milk formulas; The importance of the fatty acids in breast milk and in lacteal formulae 63.2 (2012): 131-142.
8. Valenzuela BA and Nieto KS. “Omega-6 and omega-3 fatty acids in perinatal nutrition: their importance in the development of the nervous and visual system”. Revista Chilena de Pediatría2 (2003): 149-157.
9. Rodríguez M., et al. “Molecular mechanisms of polyunsaturated fatty acids and their benefits”. Revista de Investigación Clínica3 (2005): 457-472.
10. Aranceta J and Hernandez A gil. “FUNCTIONAL FOODS AND HEALTH IN CHILDREN AND YOUNG PEOPLE. 1^st Panamericana M, editor. Madrid (2010): 216.
11. Tyson J., et al. “Adaptation of feeding to a low fat yield in breast milk”. Pediatrics2 (1992): 215-220.
12. Palau A., et al. “Dietary lipids and health. In: Unilever, editor. The White Paper on Fats in Functional Eating. Spain (2008): 41-61.
13. Argentino S., et al. “Milk production and biosynthesis” (2014): 1-6.
14. Innis SM. “Human milk and formula fatty acids”. The Journal of Pediatrics 4 (1992): S56-61.
15. Gaete GM., et al. “Effect of supplementation of the mother's diet during lactation with omega 3 fatty acids on the composition of milk lipids”. Revista Chilena de Pediatría3 (2002): 239-247.
16. Harris WS., et al. “Will dietary ω-3 fatty acids change the composition of human milk?” The American Journal of Clinical Nutrition 4 (1984): 780-785.
17. Henderson RA., et al. “Effect of fish oil on the fatty acid composition of human milk and maternal and infant erythrocytes”. Lipids11 (1992): 863-869.
18. Sanders TA and Reddy S. “The influence of a vegetarian diet on the fatty acid composition of human milk and the essential fatty acid status of the infant”. The Journal of Pediatrics 4 Pt 2 (1992): S71-77.
19. Cherian G and Sim JS. “Changes in the breast milk fatty acids and plasma lipids of nursing mothers following consumption of n-3 polyunsaturated fatty acid enriched eggs”. Nutrition 1 (1996): 8-12.
20. Ministry of Health Republic of Colombia. Resolution No. 008430”. Constitución Política de Colombia (1993): 12.
21. Iverson SJ., et al. “Comparison of the bligh and dyer and folch methods for total lipid determination in a broad range of marine tissue”. Lipids11 (2001): 1283-1287.
22. Bligh EG and Dyer WJ. “A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION”. Canadian Journal of Biochemistry and Physiology 8 (1959): 911-917.
23. Kramer JK., et al. “Analysis of conjugated linoleic acid and trans 18:1 isomers in synthetic and animal products”. The American Journal of Clinical Nutrition 6 (2004): 1137S-1145.
24. Petrović M., et al. “Optimization of the GC method for routine analysis of the fatty acid profile in several food samples”. Food Chemistry 1 (2010): 285-291.
25. Chulei R., et al. “Milk Composition in Women from Five Different Regions of China: The Great Diversity of Milk Fatty Acids”. The Journal of Nutrition 12 (1995): 2993-2998.
26. Marín M., et al. “Long-chain polyunsaturated fatty acids in breast milk in La Plata, Argentina: Relationship with maternal nutricional status”. Prostaglandins, Leukotrienes and Essential Fatty Acids 73 (2005): 355-360.
27. Larque E., et al. “Perinatal supply and metabolism of long-chain polyunsaturated fatty acids: importance for the early development of the nervous system”. Annals of the New York Academy of Sciences 967 (2002): 299-310.
28. Kovács A., et al. “Fatty acids in early human milk after preterm and full-term delivery”. Journal of Pediatric Gastroenterology and Nutrition 4 (2005): 454-459.
29. Ortega FD., et al. “Analysis of the concentration of fatty acids in colostrum and transitional milk” 46 (1997).
30. Galindo Gómez A., et al. “Adiponectin levels in breast milk of overweight/obese and normal-weight mothers in the metropolitan area of Monterrey, Mexico”. Boletín Médico del Hospital Infantil de México 4 (2015): 242-248.
31. Álvarez de Acosta T., et al. “Macronutrients in the mature milk of adolescent and adult mothers”. Archivos Latinoamericanos de Nutricion1 (2013): 46-52.
32. Jing H., et al. “Effect of Breastfeeding on Childhood BMI and Obesity”. Medicine (Baltimore)10 (2014): e55.
33. Wan Z-X., et al. “Lipid content and fatty acids composition of mature human milk in rural North China”. British Journal of Nutrition 6 (2010): 913-916.
34. Duran AS and Masson SL. “Contribution of Trans Fatty Acids, Conjugated Linoleic Acid and Docosahexaenoic Acid, in the fat of the breast milk of Chilean wet nurses”. Revista Chilena de Nutrición 1 (2010): 9-17.
35. Daud AZ., et al. “The trans fatty acid content in human milk and its association with maternal diet among lactating mothers in Malaysia”. Asia Pacific Journal of Clinical Nutrition 3 (2010): 431-442.
36. Nasser R., et al. “The effect of a controlled manipulation of maternal dietary fat intake on medium and long chain fatty acids in human breast milk in Saskatoon, Canada”. International Breastfeeding Journal 1 (2010): 3.
37. Okereke C., et al. “Evaluation of some anthropometric indices for the diagnosis of obesity in pregnancy in Nigeria: a cross-sectional study”. African Health Sciences 4 (2014): 1034.
38. McManaman JL. “Lipid transport in the lactating mammary gland”. Journal of Mammary Gland Biology and Neoplasia 1 (2014): 35-42.
39. Burrows T., et al. “A comparative validation of a child food frequency questionnaire using red blood cell membrane fatty acids”. European Journal of Clinical Nutrition 7 (2012): 825-829.
40. Bernabe-García M., et al. “Docosahexaenoic acid and arachidonic acid in neonates: is the intake they receive sufficient to cover their needs?” Boletín Médico del Hospital Infantil de México 5 (2012): 337-346.
41. Ronayne de Ferrer PA. “Importance of polyunsaturated fatty acids in infant feeding”. Archivos Argentinos de Pediatria 4 (2000).
42. Smoczyński M. “Role of Phospholipid Flux during Milk Secretion in the Mammary Gland”. Journal of Mammary Gland Biology and Neoplasia 2 (2017): 117.
43. German JB. “Dietary lipids from an evolutionary perspective: sources, structures and functions”. Maternal and Child Nutrition (2011): 2-16.
44. Rodríguez-Cruz M., et al. “Molecular mechanisms of action of polyunsaturated fatty acids and their health benefits”. Revista de Investigación Clínica 3 (2005): 457-472.
45. Bermudez J and Velasquez C. “Serum free fatty acid (BLA) profile of young Colombians with obesity and metabolic syndrome”. Archivos Latinoamericanos de Nutricion (2014): 64.
46. Mahan LK., et al. “Krause Dietoterapia”. Elsevier Health Sciences Spain (2012): 1263.
47. Vemuri M and Kelley D. “The effects of dietary fatty acids on lipid metabolism. In: CRC Press Taylor and Francis Group, editor”. Fatty Acids in Food and Their Health Implications (2007): 591-630.
48. Valentine CJ and Wagner CL. “Nutritional Management of the Breastfeeding Dyad”. P Archivos Latinoamericanos de Nutricion 1 (2013): 261-274.
49. Ares Segura S., et al. “The importance of maternal nutrition during breastfeeding, do breastfeeding mothers need nutritional supplements?” Annals of Pediatrics 6 (2016): 347.e1-347.e7.

Citation

Citation: Beatriz Estella López-Marín., et al. “Correlation between Plasma Fatty Acid Profile of Lactating Women and Content in Mature Breast Milk".Acta Scientific Nutritional Health 9.4 (2025): 66-75.

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Copyright: © 2025 Firoj A Tamboli., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.