Ananya Bhowmik¹*, Arunansu Talukdar², Debesh Roy³ and Kalpana Datta⁴

¹Department of Pediatric Centre of Excellence in HIV Care, Medical College and Hospital, Kolkata, India
²Department of General Medicine, Medical College and Hospital, Kolkata, India
³Department of Biochemistry, Medical College and Hospital, Kolkata, India
⁴Department of Pediatrics, Medical College and Hospital, Kolkata, India

*Corresponding Author: Ananya Bhowmik, Department of Pediatric Centre of Excellence in HIV care, Medical College and Hospital, Kolkata, India.

Received: March 27, 2024; Published: April 03, 2024

Abstract

Background:Children and adolescents with HIV infection are known to be wasted and underweight but it is also important to find out whether there is an effect of HIV infection on vitamin D levels among these patients.

Methods: HIV positive, Antiretroviral therapy (ART) naive patients from the age 2 to 18 years were randomly selected with consent. Healthy age and gender matched control in the ratio of 2:1 were selected. The vitamin D test was done by ELISA method. Nutritional status was determined by WHO growth standards. SPSS 16.0 was used for statistical analysis with which tests like mean median,t test and bivariate correlation was done.

Results: In a span of two years 92 cases and 58 controls were selected 65% of the study population was females and the rest were males and ages ranged from 2 to 17 the mean being 9.22 + 3.9 years. Wasting was not related to low vitamin D levels (p = 0.72) exposure to sunlight and HIV infection was significantly correlated to low vitamin D levels (p = 0.2 and p = 0.4) respectively. Among cases vitamin D levels were statistically correlated with CD4 percentage and WHO clinical staging (p = 0.01 and p = 0.00) respectively.

Conclusion: Hence from the above study it may be concluded that HIV infected children and young adults do have a reduced vitamin D level compared to their healthy counterparts. It is also important to note that progression of the HIV disease process lowers the vitamin D level which r evident in terms of CD4 percentage and WHO clinical staging. It requires further research to understand the exact reason and mechanism behind this finding.

Keywords: Vitamin D; HIV; Children; Adolescent; CD4

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Citation

Citation: Ananya Bhowmik., et al. “Vitamin D Status Among Children and Adolescents with HIV Infection".Acta Scientific Nutritional Health 8.5 (2024): 04-08.

Copyright

Copyright: © 2024 Howard Moskowitz., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.