Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Research Article Volume 8 Issue 5

Vitamin D Status Among Children and Adolescents with HIV Infection

Ananya Bhowmik1*, Arunansu Talukdar2, Debesh Roy3 and Kalpana Datta4

1Department of Pediatric Centre of Excellence in HIV Care, Medical College and Hospital, Kolkata, India
2Department of General Medicine, Medical College and Hospital, Kolkata, India
3Department of Biochemistry, Medical College and Hospital, Kolkata, India
4Department of Pediatrics, Medical College and Hospital, Kolkata, India

*Corresponding Author: Ananya Bhowmik, Department of Pediatric Centre of Excellence in HIV care, Medical College and Hospital, Kolkata, India.

Received: March 27, 2024; Published: April 03, 2024

Abstract

Background:Children and adolescents with HIV infection are known to be wasted and underweight but it is also important to find out whether there is an effect of HIV infection on vitamin D levels among these patients.

Methods: HIV positive, Antiretroviral therapy (ART) naive patients from the age 2 to 18 years were randomly selected with consent. Healthy age and gender matched control in the ratio of 2:1 were selected. The vitamin D test was done by ELISA method. Nutritional status was determined by WHO growth standards. SPSS 16.0 was used for statistical analysis with which tests like mean median,t test and bivariate correlation was done.

Results: In a span of two years 92 cases and 58 controls were selected 65% of the study population was females and the rest were males and ages ranged from 2 to 17 the mean being 9.22 + 3.9 years. Wasting was not related to low vitamin D levels (p = 0.72) exposure to sunlight and HIV infection was significantly correlated to low vitamin D levels (p = 0.2 and p = 0.4) respectively. Among cases vitamin D levels were statistically correlated with CD4 percentage and WHO clinical staging (p = 0.01 and p = 0.00) respectively.

Conclusion: Hence from the above study it may be concluded that HIV infected children and young adults do have a reduced vitamin D level compared to their healthy counterparts. It is also important to note that progression of the HIV disease process lowers the vitamin D level which r evident in terms of CD4 percentage and WHO clinical staging. It requires further research to understand the exact reason and mechanism behind this finding.

Keywords: Vitamin D; HIV; Children; Adolescent; CD4

References

  1. Holick MF., et al. “Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy”. The Journal of Clinical Endocrinology and Metabolism6 (2005): 3215-3224.
  2. Lips P., et al. “The prevalance of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation”. Journal of Internal Medicine 260 (2006): 245-254.
  3. Vieth R. “Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety”. The American Journal of Clinical Nutrition 5 (1999): 842-856.
  4. Bischoff-Ferrari HA., et al. “Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials”. JAMA18 (2005): 2257-2264.
  5. Gartner LM and Greer FR. “Prevention of rickets and vitamin D deficiency: new guidelines for vitamin D intake”. Pediatrics 4 (2003): 908-10.
  6. Misra M., et al. “Nutrient intake in community-dwelling adolescent girls with anorexia nervosa and in healthy adolescents”. The American Journal of Clinical Nutrition 4 (2006): 698-706.
  7. Hartman JJ. “Vitamin D deficiency rickets in children: prevalence and need for community education”. Orthopaedic Nursing1 (2000): 63-67. quiz 67-69.
  8. O’Brien KO., et al. “Bone mineral content in girls perinatally infected with HIV”. The American Journal of Clinical Nutrition 73 (2001): 821-826.
  9. Madeddu G., et al. “Bone mass loss and vitamin D metabolism impairment in HIV patients receiving highly active antiretroviral therapy”. Quarterly Journal of Nuclear Medicine and Molecular Imaging 48 (2004): 39-48.
  10. Mondy K., et al. “Alendronate, vitamin D, and calcium for the treatment of osteopenia/osteoporosis associated with HIV infection”. Journal of Acquired Immune Deficiency Syndromes 38 (2005): 426-431.
  11. Haug CJ., et al. “Severe deficiency of 1,25-dihydroxyvitamin D3 in human immunodeficiency virus infection: association with immunological hyperactivity and only minor changes in calcium homeostasis”. The Journal of Clinical Endocrinology and Metabolism11 (1998): 3832-3838.
  12. Holick MF., et al. “Evaluation, treatment, and prevention of Vitamin D deficiency: An endocrine society clinical practice guideline”. The Journal of Clinical Endocrinology and Metabolism 96 (2011): 1911-1930.
  13. McHenry MS., et al. “Growth of young HIV-infected and HIV-exposed children in western Kenya: A retrospective chart review”. PLoS ONE12 (2019): e0224295.
  14. Joy A. “Weydert Vitamin D in children’s health”. Children (Basel)2 (2014): 208-226.
  15. Ayesha M., et al. “Vitamin D Deficiency in HIV-Infected Children”. South Medical Journal11 (2016): 683-687.

Citation

Citation: Ananya Bhowmik., et al. “Vitamin D Status Among Children and Adolescents with HIV Infection".Acta Scientific Nutritional Health 8.5 (2024): 04-08.

Copyright

Copyright: © 2024 Howard Moskowitz., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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