Kuchkarova Lubov Salijanovna¹* and Kayuumov Khasan Usuf ogli²

¹Doctor of Biological Science, Professor of the Human and Animal Physiology Department, National University of Uzbekistan, Uzbekistan ¹Assistant of the Human and Animal Physiology Department, National University of Uzbekistan, Uzbekistan

*Corresponding Author: Kuchkarova Lubov Salijanovna, Doctor of Biological Science, Professor of the Human and Animal Physiology Department, National University of Uzbekistan, Uzbekistan.

Received: October 25, 2023; Published: November 27, 2023

Abstract

The preventive effect of flavonoids such as rutin, dihydroquercetin, pulicaron and tamiflazide on the absorption of glucose from solutions of starch, maltose, sucrose, and glucose in the small intestine at acute pancreatitis was studied in experiments on Wistar rats. Flavonoids were administered intragastrically at a dose of 20 mg/kg for 5 days before the induction of experimental pancreatitis. Experimental pancreatitis was induced by administration of L-arginine at a dose of 500 mg/100 g body weight at 12-hour intervals. It turned out that experimental pancreatitis led to inhibition of glucose absorption from 0,2% starch solutions as well as from 2% maltose, sucrose and glucose solution in the isolated small intestine segment. Rutin, dihydroquercetin and tamiflazide prevented inhibition of glucose absorption from the small intestine caused by pancreatitis from all substrates. Pulicaron did not have any preventive effect on the repression of glucose absorption from the small intestine. Consequently, rutin, dihydroquercetin and tamiflazide can be used as anti-pancreatic drugs for prevention of glucose inhibition absorption in the small intestine.

Keywords: Small Intestine; Starch; Disaccharides; Glucose Saccharide; Absorption; Rutin; Dihydroquercetin; Pulicaron; Tamiflazide

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Citation

Citation: Kuchkarova Lubov Salijanovna and Kayuumov Khasan Usuf ogli. “Preventive Effect of Flavonoids on Glucose Absorption from the small Intestine in Rats with Experimental Pancreatitis".Acta Scientific Nutritional Health 7.12 (2023): 23-26.

Copyright

Copyright: © 2023 Kuchkarova Lubov Salijanovna and Kayuumov Khasan Usuf ogli. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.