Associations of Dietary Methyl-Group Donors with Epigenetics through One-Carbon
Metabolism in Breast Cancer Risk
Risa Asada1, Sho Maruyama2, Gakuto Homma2 and Yuji Aoki1,2*
1Department of Health and Nutritional Science, Matsumoto University, Japan
2DMatsumoto University Graduate School of Health Science, Japan
*Corresponding Author: Yuji Aoki, Department of Health and Nutritional Science,
Matsumoto University, Japan.
August 02, 2023; Published: August 22, 2023
In Japan, age-specific incidence rates of breast cancer exhibited an increase trend from 2005 to 2015, showing a bimodal distribution pattern with pre- and postmenopausal peaks. This suggests the involvement of modifiable lifestyle factors in the development and progression of breast cancer. Epigenetic changes, such as DNA methylation and histone modifications, could play a crucial role in these processes. Certain nutrients, including folate and methionine, act as methyl-group donors within the one-carbon metabolism pathway, contributing to histone and DNA methylation. In this mini-review, we provide a brief overview of epigenetic modifications, particularly in relation to one-carbon metabolism, and explore the potential impact of dietary methyl-group donor intake on breast cancer risk. Overall, the influence of dietary intake of folate or methionine on breast cancer risk may exhibit a potential U-shaped relationship. However, the exact contribution of methyl-group donors through epigenetics to breast cancer development remains somewhat illusive. The metabolic network involved in one-carbon metabolism suggests that high folate or methionine intake may contribute to breast cancer progression. As breast cancer incidence continues to rise among Asian women, further research on the interactions between nutrition and epigenetics, which may be reversible, is expected to advance breast cancer prevention and treatment.
Keywords: Breast Cancer; Epigenetics, Folate; Methionine, One-Carbon Metabolism
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