Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Research Article Volume 7 Issue 9

Glycaemic and Lipidemic Profile of Type-2 Diabetic Adults: An Intervention Study with Capparis Decidua

A Calabrò1*, C Bagnato2, R Paone3, MV Pirrò4, F Iannelli5, S Pellicano5, A Pirillo5, M Pungitore5, C Rosselli5 and Claudia Paone5

1Degree Course in Motor Sciences University of Catanzaro "Magna Grӕcia, Italy
2Clinical Nutrition Unit, Madonna Delle Grazie Hospital, Matera Italy, Italy
3Physiotherapist, "Villa del Sole" Nursing Home, Catanzaro, Italy
4Physiotherapist, Department of Orthopedics and Traumatology, Soverato Hospital, Italy
5Dietitian, Freelance, Italy

*Corresponding Author: A Calabrò, Degree Course in Motor Sciences University of Catanzaro "Magna Grӕcia, Italy.

Received: July 27, 2023; Published: August 17, 2023

Abstract

Background: Arthrosis is a degenerative disease that affects the cartilage that lines the bones at the level of the joints. This leads to a progressive joint deformity and a limitation in the movements of the joint heads with consequent pain. In Italy about 4 million people are affected by osteoarthritis and this represents 72% of all rheumatic disorders. Unfortunately, there are currently no definitive cures but therapies capable of inducing remission and increasing life expectancy, if diagnosed in time. People who suffer from it are often forced to leave their jobs and face excessive costs for social and health care. The progression of the disease, if not well controlled, affects the progression of quality of life, the frequency of hospitalizations and productivity. Unfortunately, according to the latest data, there are several degenerative conditions of the coxofemoral joint that also affect younger patients. Conservative surgical treatment, possible when the degeneration is modest, aims to stabilize the joint and reduce the overload on the surface.

Objectives: Overweight and obesity can exert a greater load due to weight gain; however, there may be differential systemic effects depending on the degree of fat versus lean mass. From the point of view of biomechanics, joint overload was considered one of the main causes of the onset and progression of osteoarthritis. To minimize the risk of hip osteoarthritis it is important to avoid overweight, the assumption of incorrect postures and excessive and repeated load on the joint. The goal of our study is to demonstrate, through the literature, how a low-calorie diet and physical activity, it is possible to help people with osteoarthritis to find benefit from this debilitating pathology.

Methods: However, there are few studies on how a correct diet is useful or able to reduce inflammation and the various forms of osteoarthritis. Furthermore, the course of the disease involves a rapid increase in pain, muscle-tendon and joint stiffness with consequent loss of range of motion (ROM) and muscle strength, due to the decrease in mobility.

Results: Several studies show how the regular practice of physical exercise can slow down the aggravation of complications, becoming a useful tool to support drug treatment in pain management.

Conclusions: Therefore, although maintenance of daily physical activity is recommended for patients with osteoarthritis, adequate nutrition, particularly a low-calorie or ketogenic diet, is also recommended in order to prevent daily cumulative excessive load on the hip and progression of the osteoarthritis (HOA). This is why it is important, for these patients, the figure of a Dietitian, a Physiotherapist and qualified personnel who evaluate the patient's physical activity in order to preserve functional independence, muscle strength and reduce or remove the complications that this clinical condition can lead.

Keywords: Osteoarthritis; Arthosis; Disability; Low Calorie Diet; Physical Activity

References

  1. Elena Rezus., et al. “The Link Between Inflammaging and Degenerative Joint Diseases”. International Journal of Molecular Sciences 20.3 (2019): 614.
  2. Johannes WJ Bijlsm., et al. “Osteoarthritis: an update with relevance for clinical practice”. Lancet 377.9783 (2011): 2115-2126.
  3. Hough AJ. “Pathology of osteoarthritis”. In: Moskowitz RW, Howell DS, Altman RD, Buckwalter JA, Goldberg VM. Osteoarthritis. 3th edition 4 (2001): 69-99.
  4. LM Marzo., et al. “Economics of osteoarthritis: a global perspective”. Baillière's Clinical Rheumatology 11.4 (1997): 817-834.
  5. Anna Flego., et al. “Addressing obesity in the management of knee and hip osteoarthritis - weighing in from an economic perspective”. BMC Musculoskeletal Disorders 17 (2016): 233.
  6. Pedro A Laires., et al. “The impact of osteoarthritis on early exit from work: results from a population-based study”. BMC Public Health 18.1 (2018): 472.
  7. Un Ariani., et al. “The Italian Society for Rheumatology clinical practice guidelines for the diagnosis and management of knee, hip and hand osteoarthritis”. Reumatismo 71.S1 (2019): 5-21.
  8. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017”. Lancet 392.10159 (2018): 1789-1858.
  9. Kai Qiao., et al. “Diagnostic and Therapeutic Role of Extracellular Vesicles in Articular Cartilage Lesions and Degenerative Joint Diseases”. Frontiers in Bioengineering and Biotechnology 9 (2021): 698614.
  10. David J Hunter., et al. “Osteoarthritis”. Lancet 393.10182 (2019): 1745-1759.
  11. Carel TJ Hulshof., et al. “WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of exposure to occupational ergonomic risk factors and of the effect of exposure to occupational ergonomic risk factors on osteoarthritis of hip or knee and selected other musculoskeletal diseases”. Environment International 125 (2019): 554-566.
  12. Svetlana Krasnokutsky., et al. “Serum Urate Levels Predict Joint Space Narrowing in Non-gout Patients with Medial Knee Osteoarthritis”. Arthritis and Rheumatology 69.6 (2017): 1213-1220.
  13. Xiaolei Ren., et al. “Patients’ risk factors for periprosthetic joint infection in primary total hip arthroplasty: a meta-analysis of 40 studies”. BMC Musculoskeletal Disorders 22 (2021): 776.
  14. Aleeson Eka., et al. “Patient-related medical risk factors for periprosthetic joint infection of the hip and knee”. Annals of Translational Medicine 3.16 (2015): 233.
  15. C Xu., et al. “Interaction of obesity with smoking and inflammatory arthropathies increases the risk of periprosthetic joint infection: a propensity score matched study in a Chinese Han population”. Journal of Hospital Infection 101.2 (2019): 222-228.
  1. ME Candela. “Resident mesenchymal progenitors of articular cartilage”. Matrix Biology 39 (2014): 44-49.
  1. Bingjiang Xia., et al. “Osteoarthritis pathogenesis: a review of molecular mechanisms”. Calcified Tissue International 95.6 (2014): 495-505.
  2. Steve Stegen., et al. “HIF-1α metabolically controls: collagen synthesis and modification in chondrocytes”. Nature 565.7740 (2019): 511-515.
  3. Kaizhe Chen., et al. “Increased 15-lipoxygenase-1 expression in chondrocytes contributes to the pathogenesis of osteoarthritis”. Cell Death and Disease 8.10 (2017): e3109.
  4. Sharon L Kolasinski., et al. “2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee”. Arthritis Care and Research (Hoboken) (2019).
  5. Josef S Smolen., et al. “EULAR Recommendations for the Management of Rheumatoid Arthritis with Synthetic and Biological Disease-Modifying Antirheumatic Drugs: 2019 Update”. Annals of the Rheumatic Diseases 79.6 (2019): 685-699.
  6. FB Pizzini. “Degenerative spine disease: Italian position paper on acquisition, interpretation and reporting of Magnetic Resonance Imaging”. Insights Imaging 12 (2021): 14.
  7. Kai Sun., et al. “Mitophagy in degenerative joint diseases”. Autophagy 17.9 (2021): 2082-2092.
  8. R Bourne., et al. “Role of obesity on the risk for total hip or knee arthroplasty”. Clinical Orthopaedics and Related Research® 465 (2007): 185-188.
  9. MA Martinez-Gonzàlez., et al. “Physical inactivity, sedentary lifestyle and obesity in the European Union”. International Journal of Obesity and Related Metabolic Disorders 23.11 (1999): 1192-201.
  10. RE Leach., et al. “Obesity: its relationship to osteoarthritis of the knee”. Clinical Orthopaedics and Related Research® 93 (1973): 271-273.
  11. C Paone., et al. “Efficacy and Tolerability of the Ketogenic Diet Compared to the Mediterranean Diet in a Cohort of Overweight/Obese Patients: Effects on Anthropometric and Metabolic Parameters”. IRJPMS 5.2 (2000): 11-18.
  12. Maria M Wertli., et al. “Obesity is associated with more disability at presentation and after treatment in low back pain but not in neck pain: findings from the OIOC registry”. BMC Musculoskelet Disorder 17 (2016): 140.
  13. Steven B Abramson., et al. “Developments in the scientific understanding of osteoarthritis”. Arthritis Research and Therapy 11.3 (2009): 227.
  14. RE Leach., et al. “Obesity: its relationship to osteoarthritis of the knee”. Clinical Orthopaedics and Related Research 93 (1973): 271-273.
  15. Maria Grorud Fagerhøi., et al. “The effect of brief versus individually tailored dietary advice on change in diet, lipids and blood pressure in patients with inflammatory joint disease”. Food and Nutrition Research (2018): 62.
  16. DB Précoma., et al. “Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology – 2019”. Arquivos Brasileiros de Cardiologia 113.4 (2019): 787-891.
  17. AC Vergnaud., et al. “Weight fluctuations and risk for metabolic syndrome in an adult cohort”. International Journal of Obesity32.2 (2008): 315-321.
  18. NS Harasymowicz., et al. “Physiologic and pathologic effects of dietary free fatty acids on cells of the joint”. Annals of the New York Academy of Sciences 1440.1 (2019): 36-53.
  19. Francis Berenbaum., et al. “Metabolic Regulation of Inflammation in Osteoarthritis”. Arthritis and Rheumatology 69.1 (2017): 9-21.
  20. LC Ramires., et al. “The Association between Gut Microbiota and Osteoarthritis: Does the Disease Begin in the Gut?” International Journal of Molecular Sciences 23.3 (2022): 1494.
  21. Collison RJ., et al. “Siberian Ginseng (Eleutherococcus senticosus)”. Phytotherapy in Brazil 2 (1991): 61-71.
  22. Asano K., et al. “Effect of Eleutherococcus senticosus extract on human physical working capacity”. Planta Medica 3 (1986): 175-177.
  23. Kuo J., et al. “The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human”. Chinese Journal of Physiology 53 (2010): 105-111.
  24. M Grotle., et al. “Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up”. BMC Musculoskeletal Disorders 9 (2008): 132.
  25. Goulet E., et al. “Assessment of the effects of Eleutherococcus senticosus on endurance performance”. International Journal of Sport Nutrition and Exercise Metabolism 15 (2005): 75-83.
  26. JA Singh., et al. “Chondroitin for osteoarthritis”. Cochrane Database of Systematic Reviews 1 (2015): CD005614.
  27. Clegg DO., et al. “Glucosamine, chondroitin sulfate, and two in combination for painful knee osteoarthritis”. The New England Journal of Medicine 354 (2006): 795-808.
  28. Bartels EM., et al. “Aquatic exercise for the treatment of knee and hip osteoarthritis”. Cochrane Database of Systematic Reviews 4 (2007): CD995523.
  29. Hurkmans E., et al. “Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid arthritis”. Cochrane Database of Systematic Reviews 7 (2009): CD006853.
  30. Summer GD., et al. “Rheumatoid cachexia: a clinical perspective”. Rheumatology 47.8 (2008): 1124-31.
  31. Van den Ende C., et al. “Dynamic exercise therapy for treating rheumatoid arthritis”. In: Van den Ende E, editor”. Cochrane Database of Systematic Reviews. Chichester, UK: John Wiley and Sons, Ltd (1998).
  32. Westby DM. “A health professional’s guide to exercise prescription for peole with arthritis: a review of aerobic fitness activities”. Arthritis and Rheumatology 45.6 (2001): 501-511.
  33. Brosseau L., et al. “Intensity of exercise for the treatment of osteoarthritis”. Cochrane Database of Systematic Reviews 2 (2003): CD004259.
  34. Dagfinrud H., et al. “Physiotherapy interventions for ankylosing spondylitis”. Cochrane Database of Systematic Reviews 1 (2008): CD002822.
  35. Frasen M and McConnell S. “Exercise for osteoarthritis of the knee”. Cochrane Database of Systematic Reviews 4 (2008):CD004376.
  36. Frasen M., et al. “Exercise for osteoarthitis of the hip”. Cochrane Database of Systematic Reviews 3 (2009): CD007912.
  37. Metsios G., et al. “Rheumatoid arthritis, cardiovascular disease and physical exercise: a systematic review”. Rheumatology 47 (2008): 239-248.
  38. Forestier R., et al. “Non-drug treatment (excluding surgery) in rheumatoid arthritis: clinical practice guidelines”. Joint Bone Spine 76.6 (2009): 691-698.
  39. Centers for Disease Control and Prevention. National and state medical expenditures and lost earings attriburable to arthritis and other rheumaatic conditions-United States, 2003”. MMWR Morbidity and Mortality Weekly Report 56 (2007): 4-7.
  40. Centers for Disease Control and Prevention. “Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation - United States, 2010-2012”. MMWR Morbidity and Mortality Weekly Report 62 (2013): 869-873.
  41. Hootman JM and Helmick C. “Projections of US prevalence of arthitis and associated activity limitations”. Arthritis and Rheumatology 54.1 (2006): 226-229.
  42. Minor MA., et al. “Efficacy of physical conditioning exercise in patients with rheumatoid arthritis and osteoarthritis” Arthritis and Rheumatism 32.11 (1989).
  43. Ytterberg SR., et al. “Exercise for arthritis”. Baillière's Clinical Rheumatology 8.1 (1994): 161-189.
  44. Knittle K., et al. “Targeting motivation and self-regulation to increase physical activity among patients with rheumatoid arthritis: a randomized controlled trial”. Clinical Rheumatology 34.2 (2015):231-238.
  45. Brodin N., et al. “Coaching patients with early rheumatoid arthritis to healthy physical activity: a multicenter, randomized, controlled study”. Arthritis and Rheumatology 59.3 (2008): 325-331.
  46. Sport Science Institute of South Africa. UCT/MRC Research Unit for Exercise Science and Sport Medicine, Munneke M, International Federation of Sports Medicine., De Jong Z. International sportmed journal-The role of exercise programs in the rehabilitation of patients with rheumatoid arthritis for FIMS: ISMJ. Vol.1 ISMJ”. Human Kinetics Publishers (2000): 1-12.
  47. Heinonen A., et al. “Randomised controlled trial of effect of high-impact exercise on selected risk factors for osteoporotic fractures”. Lancet 348 (1996): 1343-1347.
  48. Hourigan SR., et al. “Positive effects of exercise on fall sand fracture risk in osteopenic women”. Osteoporosis International 19 (2008): 1077-1086.
  49. Korpelainen R., et al. “Effect of exercise on extraskeletal risk factors for hip fractures in elderly women with low BMD: a population-based randomized controlled trial”. Journal of Bone and Mineral Research 21 (2006): 772-779.
  50. Metsios GS., et al. “Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis”. European Journal of Cardiovascular Prevention and Rehabilitation 16 (2009): 188-194.
  51. Baillet A., et al. “Efficacy of Cardiorespiratory Aerbic Exercise in Rheumatoid Arthritis: Meta-Analysis of Randomized Controlled Trials”. Arthritis Care and Research 62.7 (2010).
  52. Neuberger GB., et al. “Predictors of exercise and effects of exercise on symptoms, function, aerobic fitness, and disease outcomes of rheumatoid arthritis”. Arthritis and Rheumatology 57 (2007): 943-952.

Citation

Citation: A Calabrò., et al. “Effects of the Low-Calorie Diet and Adapted Physical Activity on Subjects Suffering from Osteoarthritis".Acta Scientific Nutritional Health 7.9 (2023): 79-86.

Copyright

Copyright: © 2023 A Calabrò., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.316

Indexed In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US