Indoria Archana and Boolchandani Reshama

Research Scholar, Department of Home Science, University of Rajasthan Jaipur

*Corresponding Author: Indoria Archana, Research Scholar, Department of Home Science, University of Rajasthan Jaipur.

Received: July 24, 2023; Published: August 16, 2023

Abstract

Introduction: Indian population is moving towards non communicable diseases at an alarming rate, with Type 2 Diabetes mellitus (T2DM) affecting a huge segment of adults, so much so that India has become the Diabetes capital of the world. Along with the various treatment options available, some plant-based options can be explored for their phytochemical properties and nutritional benefits, along with the allopathic treatment options available. One such option that can be tapped is the fruit of Capparis decidua (Kair), which is commonly consumed in various parts of India, especially Rajasthan. It has been traditionally used as an antidiabetic agent but there are very few published research studies regarding its medicinal use, hence it was chosen for the present study.

Objective: The present study evaluated the antihyperglycemic and antihyperlipidemic effects of Capparis decidua powder on adult men and women with Type 2 Diabetes mellitus.

Methodology: The Capparis decidua powder was orally given to adult men and women with T2DM at the dose of 250mg/kg body weight for an intervention period of 90 days. Adult male and female diabetic patients in the age group between 35 to 55 years using purposive sampling technique, who are fulfilling inclusion criteria were selected for the present study.

Results: Changes in Biochemical parameters (Fasting blood glucose, post prandial blood glucose, Hba1c, Total cholesterol, Triglyceride, HDL, LDL and VLDL) were found to be statistically significant at 5% level of significance.

Conclusion: Capparis decidua powder has potent antidiabetic and antihyperlipidemic activities.

Keywords: Glycaemic; Lipidemic Profile; Capparis Decidua

References

1. Gossell-Williams M., et al. “The past and present use of plants for medicines”. West Indian Medical Journal 4 (2006): 217-218.
2. Azaizeh H., et al. “Ethnobotanical knowledge of local Arab practitioners in the Middle Eastern region”. Fitoterapia1-2 (2003): 98-108.
3. Cragg GM and D Newman. “Natural product drug discovery in the next millennium”. Pharmaceutical Biology 1 (2001): 8-17.
4. Cragg GM and DJ Newman. “Natural products: A continuing source of novel drug leads”. Biochimica et Biophysica Acta (BBA) 6 (2013): 3670-3695.
5. Yadav RNS and Agarwala M. “Phytochemical analysis of some medicinal plants”. Journal of Phytology12 (2011).
6. Nostro A., et al. “Extraction methods and bioautography for evaluation of medicinal plant antimicrobial activity”. Letters in Applied Microbiology5 (2000): 379-384.
7. Alwin Robert A and Al Dawish MA. “Microvascular complications among patients with diabetes: An emerging health problem in Saudi Arabia”. Diabetes and Vascular Disease Research3 (2019): 227-235.
8. Ighodaro OM. “Molecular pathways associated with oxidative stress in diabetes mellitus”. Biomedicine and Pharmacotherapy 108 (2018): 656-662.
9. Hogan MC., et al. “Maternal mortality for 181 countries, 1980–2008: a systematic analysis of progress towards Millennium Development Goal 5”. The Lancet 9726 (2010): 1609-1623.
10. Ranjit UI., et al. “Importance of controlling diabetes early-the concept of metabolic memory, legacy effect and the case for early insulinisation”. Journal of the Association of Physicians of India 59 (2011): 8-12.
11. Montazeri ALI., et al. “Health Literacy for Iranian Adults (HELIA): development and psychometric properties (2014).
12. Cai Y., et al. “Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer”. Life Sciences 17 (2004): 2157-2184.
13. Muhammad G., et al. “Mimosa pudica L., a high‐value medicinal plant as a source of bioactives for pharmaceuticals”. Comprehensive Reviews in Food Science and Food Safety2 (2016): 303-315.
14. Fabricant D and NR Fransworth. “The value of plants used in Traditional Medicine for Drug discovery”. Environmental Health Perspective 109 (2001): 63-75.
15. Shah A., et al. “Ethnobotanical study of medicinal plants of semi- tribal area of Makerwal and Gulla Khel (Lying between Khyber Pakhtunkhwa and Punjab provinces), Pakistan”. American Journal of Plant Sciences 4 (2013): 98-116.
16. Shad AA., et al. “Phytochemical and biological activities of four wild medicinal Plants”. The Scientific World Journal (2014).
17. Ashraf A., et al. “Phenolic compounds’ characterization of Artemisia rutifolia spreng from Pakistani flora and their relationships with antioxidant and antimicrobial attributes”. International Journal of Food Properties 11 (2017): 2538-2549.
18. Hussain S., et al. “Alternative and traditional medicines systems in Pakistan: history, regulation, trends, usefulness, challenges, prospects and limitations”. A Compendium of Essays on Alternative Therapy (2012): 89-108.
19. Shi QW., et al. “Study on natural medicinal chemistry and new drug development”. Chinese Traditional and Herbal Drugs 41 (2010): 1583-1589.
20. Hussain S., et al. “Alternative and traditional medicines systems in Pakistan: history, regulation, trends, usefulness, challenges, prospects and limitations”. A Compendium of Essays on Alternative Therapy (2012): 89-108.
21. Hossen MJ., et al. “AP-1-targeting anti-inflammatory activity of the methanolic extract of Persicaria chinensis”. Evidence-Based Complementary and Alternative Medicine (2015).
22. Muhammad G., et al. “Alhagi: a plant genus rich in bioactives for pharmaceuticals”. Phytotherapy Research1 (2015): 1-13.
23. World Health Organization. “Diarrhoea: why children are still dying and what can be done” (2009).
24. Rates SMK. “Plants as source of drugs”. Toxicon5 (2009): 603-613.
25. Russell W and Duthie G. “Plant secondary metabolites and gut health: the case for phenolic acids”. Proceedings of the Nutrition Society3 (2011): 389-396.
26. Abesundara KJM., et al. “α-Glicosidase inhibitory activity of some Sri Lanka plant extracts, one of which, Cassia auriculata, exerts a strong antihyperglycemic effect in rats comparable to the therapeutic drug acarbose”. Journal of Agricultural and Food Chemistry 52 (2004): 2541-2545.
27. Chopra RN., et al. “Glossary of Indian medicinal plants, national institute of science communication and information resources”. New Delhi: CSIR (1992): 203.
28. Gupta RK. “Medicinal and Aromatic Plants, CBS Publishers and Distributors Pvt”. Ltd, Edition 1^st (2010): 114-115.
29. Gull T., et al. “Variation of proximate composition and minerals within different parts of Capparis decidua (Forssk.) Edgew. as a function of harvesting seasons”. Pakistan Journal of Botany 5 (2015): 1743-1748.
30. Danaei G., et al. Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Blood Glucose. “National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants”. The Lancet9785 (2011): 31-40.
31. Ali S., et al. “The prevalence of co‐morbid depression in adults with Type 2 diabetes: a systematic review and meta‐analysis”. Diabetic Medicine11 (2006): 1165-1173.
32. Kwon YI., et al. “Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension”. Asia Pacific Journal of Clinical Nutrition 3 (2006): 209-218.
33. Jayasri MA., et al. “Anti-diabetic effect of Costus pictus leaves in normal and streptozotocin-induced diabetic rats”. Dubai Diabetes and Endocrinology Journal3 (2009): 117-122.
34. Zia-Ul-Haq M., et al. “Compositional studies: antioxidant and antidiabetic activities of Capparis decidua (Forsk.) Edgew”. International Journal of Molecular Sciences12 (2011): 8846-8861.
35. Yadav P., et al. “Action of capparis decidua against alloxan-induced oxidative stress and diabetes in rat tissues”. Pharmacological Research3 (1997): 221-228.
36. Yadav P., et al. “Lipid peroxidation and antioxidant enzymes in erythrocytes and tissues in aged diabetic rats”. Indian Journal of Experimental Biology4 (1997): 389-392.
37. Sharma B., et al. “Anti-diabetic potential of alkaloid rich fraction from Capparis decidua on diabetic mice”. Journal of Ethnopharmacology2 (2010): 457-462.
38. Dangi KS and Mishra SN. “Antihyperglycemic, antioxidant and hypolipidemic effect of Capparis aphylla stem extract in streptozotocin induced diabetic rats”. Biology and Medicine4 (2010): 35-44.
39. Ogbonnia SO., et al. “Effect of a poly-herbal formulation, Okudiabet, on alloxan-induced diabetic rats” (2010).
40. Ram A., et al. “Hypocholesterolaemic effects of Terminalia arjuna tree bark”. Journal of Ethnopharmacology3 (1997): 165-169.
41. Sharma SR., et al. “Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of Caesalpinia bonducella seeds in rats”. Journal of Ethnopharmacology1 (1997): 39-44.
42. Nancy P., et al. “Antiplaque activity of Juglans regia L. and characterization of Juglone from Juglans regia L”. The American Journal of Biochemistry and Biotechnology1 (2011): 29-31.
43. Olas B., et al. “Inhibition of blood platelet adhesion and secretion by different phenolics from Yucca schidigera Roezl. Bark”. Nutrition2 (2005): 199-206.
44. Chahlia N. “Evaluation of hypolipidaemic activity of Capparis decidua”. International Journal of Biomedical Science: IJBS1 (2009): 70.
45. Mutalik S., et al. “Effect of Dianex, a herbal formulation on experimentally induced diabetes mellitus”. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives5 (2005): 409-415.
46. Goyal R and Grewal RB. “The influence of teent (Capparis decidua) on human plasma triglycerides, total lipids and phospholipids”. Nutrition and Health1 (2003): 71-76.
47. Pedersen TR. “Pro and con: low-density lipoprotein cholesterol lowering is and will be the key to the future of lipid management”. The American Journal of Cardiology5 (2001): 8-12.
48. Agarwal V and Chauhan BM. “A study on composition and hypolipidemic effect of dietary fibre from some plant foods”. Plant Foods for Human Nutrition 38 (1988): 189-197.
49. Pai MR., et al. “Evaluation of antiplaque activity of Azadirachta indica leaf extract gel-a 6-week clinical study”. Journal of Ethnopharmacology 1 (2004): 99-103.
50. Mehta K., et al. “Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits”. Journal of Ethnopharmacology2-3 (2003): 191-195.
51. Boden WE and Pearson TA. “Raising low levels of high-density lipoprotein cholesterol is an important target of therapy”. American Journal of Cardiology5 (2000): 645-650.
52. Purohit A and Vyas KB. “Antiatherosclerotic effect of Caparis decidua. Fruit extract in cholesterol-fed rabbits”. Pharmaceutical Biology3 (2006): 172-177.

Citation

Citation: Indoria Archana and Boolchandani Reshama. “Glycaemic and Lipidemic Profile of Type-2 Diabetic Adults: An Intervention Study with Capparis Decidua". Acta Scientific Nutritional Health 7.9 (2023): 72-78.

Copyright

Copyright: © 2023 Indoria Archana and Boolchandani Reshama. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.