Activities Of Fermented Maman (Cleome gynandra L) On Blood Sugar Level in
Hyperglycemic White Rats
Lily Restusari*, Muharni and Fitri
Department of Nutrition, Riau Health Polytechnic of Indonesian Republic Health
Ministry, Indonesia
*Corresponding Author: Lily Restusari, Department of Nutrition, Riau Health Polytechnic of Indonesian Republic Health Ministry, Indonesia.
Received:
April 10, 2023; Published: June 23, 2023
Abstract
Cleome gynandra L. (called as “Maman” in Riau) is a traditional medicine used for diabetes, anti-aging, anti-cancer and cardiovascular diseases prevention. This study was carried out to determine the activities of Fermented Maman on blood sugar levels in hyperglycemic male white rats. The research was an experimental research, using the Post Test Only Control Group Design, that carried out 5 months at Riau Ministry of Health Poltekkes Laboratory. The data analysis using Multivariate ANOVA and continued with Duncan multiple range test.The results of the study indicate that Fermented Maman can reduce blood sugar levels but, the metformin group had a higher reduction compared to the control group negative, positive and Fermented Maman. Metformin reduces blood sugar levels better than Fermented Maman. It is necessary to add the time of Fermented Maman and research used metformin with simultaneous fermentation in groups of male white rats with dosage variations.
Keywords: Hyperglycemia; Maman (Cleome gynandra L); Fermented Maman; Diabetes; Traditional Medicine
References
- Departemen Kesehatan Republik “Profil Kesehatan 2005”. Jakarta (2006).
- IDF Diabetes Atlas Sixth Edition. International Diabetes Federation (2013).
- Pusat Data dan Informasi Kementrian Kesehatan RI. “Situasi dan Analisis Diabetes”. Jakarta (2014).
- Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI tahun Laporan “Riset Kesehatan Dasar (RISKESDAS) 2013”. Badan Litbangkes Kemkes RI (2014).
- Mishra , et al. “Review on Cleome Gynandra”. IJRCP 1.3 (2011): 681-688.
- Saida EM. “Identifikasi Bakteri Patogen pada Produk Fermentasi Cleome gynandra. Riau, Indonesia: Scientific Paper, Nutrition Major of Riau Ministry of Health Poltekkes (2014).
- Winarti “Makanan Fungsional’. Surabaya: Graha Ilmu (2010).
- IOM (Institute of Medicine). “Dietary Reference Intake for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids”. A Report of the Panel on Macronutrients, Subcommittees on Upper Reference Levels of Nutrients and Interpretation and Uses of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Washington DC: National Academies Press (2005).
- Muharni Restusari L. “Optimasi Kandungan Bakteri Asam Laktat Dalam Pembuatan Fermentasi Maman (Cleome Gynandra L). Riau, Indonesia, Nutrition Major of Riau Ministry of Health Poltekkes (2016).
- Leto I and Lovric T. “Identification of Phenolic Acids and Changes in Their Content During Fermentation and Ageing of White Wines Posip and Rukatac”. FTB 3 (2002): 221-225.
- Sirilun , et al. “Lactobacillus Paracasei HII01 Mediated Fermentation of Syzygium Cumini L. Fruits: Assessment of Changes in Phenolic Content and Antioxidant Capacity”. Asian Journal of Pharmaceutical and Clinical Research 11 (2018): 304-308.
- Natania A., et al. “Uji Potensi Kubis-Kubisan (Barissica sp.) dan Hasil Fermentasinya Sebagai Sumber Antioksidan Alami”. Ilmu Dan Teknologi Pangan2 (2006): 47-62.
- Rini “Sindrom Metabolik”. Journal of Majority 4.4 (2015): 88-93.
- Saha , et al. “Hypoglycemic and Antihyperlipidemic Effects Of Adiantum Caudatum In Alloxan Induced Diabetes In Rats”. Asian Journal of Pharmaceutical and Clinical Research 9 (2016): 361-363.
- Restusari , et al. “Pengaruh Konsumsi Fermentasi Maman (Cleome gynandra L) Terhadap Kadar Kolesterol Darah Pada Tikus Putih Jantan Hiperkolesterolemia. Riau, Indonesia”. Nutrition Major of Riau Ministry of Health Poltekkes (2017).
- Sirois M. “Laboratory Animal Medicine: Principles and Procedures”. United States of America: Mosby (2005): 43-45.
- Restusari , et al. “Pengaruh air rebusan (infusa) daun afrika selatan (Gynura procumbens (lour.) Merr.) Terhadap kadar gula darah mencit putih jantan diabetes. Riau, Indonesia”. Nutrition Major of Riau Ministry of Health Poltekkes (2013).
- Lenzen “The mechanisms of alloxan and streptozotocin induced diabetes”. Diabetologia 51.2 (2008): 216-226.
- Szkudelski T. “The Mechanism of Alloxan and Streptozotocin Action in β Cells of the Rat Pancreas”. Physiological Research 6 (2001): 537-546.
- Soemardji AA. “Penentuan Kadar Gula Darah Mencit Secara Cepat: Untuk Diterapkan dalam Penapisan Aktivitas Antidiabetes in Vivo”. Acta Pharmaceutica Indonesia3 (2004): 115-18.
- Barnes AS. “Obesity and Sedentary Lifestyles Risk for Cardiovascular Disease in Women”. Texas Heart Institute Journal 2 (2012): 224-227.
- Herdiani Potensi Tanaman Obat (2012).
- Zubaidah E and Septina DW. “Perbandingan Cuka Salak dan Metformin pada Tikus Diabetes Mellitus”. Jurnal Pangan dan Agroindustri1 (2016): 89-99.
- “Pancreatic Hormone and Antidiabetic Drugs”. Basic and Clinical Pharmacology 12th edition. Mc Graw (2005).
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