Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Case Report Volume 7 Issue 7

Pneumogastric Schwannoma: a Case Report

Ana F Vinha1,2*, Carla Sousa1,2, Carla Moutinho1, Carla Matos1, Liliana Espírito-Santo2, Anabela SG Costa2,3 and M Beatriz PP Oliveira2

1FP-I3ID, Institute for Research, Innovation and Development Fernando Pessoa Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal
2REQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal
3Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, University of Vigo, Ourense, Spain

*Corresponding Author: Ana F Vinha, FP-I3ID, Institute for Research, Innovation and Development Fernando Pessoa Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal.

Received: May 08, 2023; Published: June 06, 2023


Carotenoids are versatile isoprenoids that have been related to a number of health benefits. Their presence in foods, dietary intake and circulating levels have been associated with a reduced incidence of obesity, diabetes, certain types of cancer, and even lower total mortality. In this review, several considerations for their safe and sustainable use in foods mostly intended for health promotion are provided. Specifically, information about biosynthesis, sources, ingestion, and factors affecting their bioavailability is summarized. Furthermore, their health-promoting actions and their importance in public health regarding their contribution to reduce the risk of several deseases are synthesized. Also, in this review is emphasized carotenoids benefits as potential strategy for nutraceuticals, pharmaceutical and cosmetic industrial applications.This study also addressed the significant obstacles as well as the synergistic factors that interfere with the bioavailability and consequent biological functions of carotenoids. Finally, this review enhances the use of carotenoids as functional compounds in different industries.

Keywords:Natural Pigments; Chemical Strutures; Functional Properties; Bioavailability; Carotenoids Applications


  1. Vinha Ana Ferreira., et al. “Natural pigments and colorants in foods and beverages”. In: Polyphenols: Properties, Recovery, and Applications”. Charis M. Galanakis (Ed.). WP Whoodhead Publishing, Elsevier. (2018).
  2. Vinha Ana Ferreira., et al. “Food waste and by-products recovery: Nutraceutical and health potencial of carotenoids as natural pigments”. Lambert Academci Publishing (Ed.). (2020).
  3. Wendin K and Undeland I. “Seaweed as food – Attitudes and preferences among Swedish consumers. A pilot study”. International Journal of Gastronomy and Food Science 22 (2020): 100265.
  4. Shen Meng., et al. “Beyond the food label itself: How does color affect attention to information on food labels and preference for food attributes?”. Food Quality and Preference 64 (2018): 47-55.
  5. Loebnitz Natascha., et al. "Who Buys Oddly Shaped Food and Why? Impacts of Food Shape Abnormality and Organic Labeling on Purchase Intentions”. Psychology and Marketing 32.4 (2015): 408-421.
  6. Mulders Kim J M., et al. “Phototrophic pigment production with microalgae: biological constraints and opportunities”. Journal of Phycology2 (2014): 229-242.
  7. González-Peña Marco António., et al. “Chemistry, Occurrence, Properties, Applications, and Encapsulation of Carotenoids-A Review”. Plants 12 (2023): 313.
  8. Molteni Camilla., et al. "Improving the Bioaccessibility and Bioavailability of Carotenoids by Means of Nanostructured Delivery Systems: A Comprehensive Review". Antioxidants 11.10 (2022): 1931.
  9. Saini Ramesh Kumar., et al. “Carotenoids from Fruits and Vegetables: Chemistry, Analysis, Occurrence, Bioavailability and Biological Activities”. Food Research International (Ottawa, Ont.)3 (2015): 735-750.
  10. Fathalipour Mohammad., et al. “The Therapeutic Role of Carotenoids in Diabetic Retinopathy: A Systematic Review”. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 13 (2020): 2347-2358.
  11. Zhou Felix., et al. “β-Carotene conversion to vitamin A delays atherosclerosis progression by decreasing hepatic lipid secretion in mice”. Journal of Lipid Research11 (2020): 1491-1503.
  12. Sandmann Gerhard. “Diversity and origin of carotenoid biosynthesis: its history of coevolution towards plant photosynthesis”. New Phytologist 232 (2) (2021): 479-493.
  13. Sugiyama Kenjiro and Shinichi,Takaichi. “Carotenogenesis in cyanobacteria: CruA/CruP-type and CrtL-type lycopene cyclases”.The Journal of General and Applied Microbiology2 (2020): 53-58.
  14. Us-Camas Rosa., et al. “Identifying Bixa orellana New Carotenoid Cleavage Dioxygenases 1 and 4 Potentially Involved in Bixin Biosynthesis”. Frontiers in Plant Science 13 (2022): 829089.
  15. Maoka Takashi. “Carotenoids as natural functional pigments”. Journal of Natural Medicines1 (2020): 1-16.

16.   Mrowicka Małgorzata., et al. “Lutein and Zeaxanthin and Their Roles in Age-Related Macular Degeneration-Neurodegenerative Disease”. Nutrients 14.4 (2022): 827.

  1. Nwachukwu, Ifeanyi D.., et al. “Lutein and zeaxanthin: Production technology, bioavailability, mechanisms of action, visual function, and health claim status”. Trends in Food Science and Technology 49 (2016): 74-84.
  2. Esatbeyoglu Tuba and Gerald Rimbach. “Canthaxanthin: From Molecule to Function”. Molecular Nutrition and Food Research6 (2017): 10.
  3. Castangia Ines., et al. "Canthaxanthin Biofabrication, Loading in Green Phospholipid Vesicles and Evaluation of In Vitro Protection of Cells and Promotion of Their Monolayer Regeneration”. Biomedicines 10,1 (2022): 157.
  4. Cristaldi Martina., et al. “Comparative Efficiency of Lutein and Astaxanthin in the Protection of Human Corneal Epithelial Cells In Vitro from Blue-Violet Light Photo-Oxidative Damage”. Applied Sciences 12.3 (2022): 1268.
  5. Capelli Bob., et al. “Astaxanthin sources: Suitability for human health and nutrition”. Functional Foods in Health and Disease 9 (2019): 430-445.
  6. Nair Anagha., et al. “Astaxanthin as a King of Ketocarotenoids: Structure, Synthesis, Accumulation, Bioavailability and Antioxidant Properties”. Marine Drugs 21 (2023): 176.
  7. Vilar Daniela de Araújo., et al. “Traditional uses, chemical constituents, and biological activities of Bixa orellana L.: a review”. The Scientific World Journal 2014 (2014): 857292.
  8. Przybylska Sylwia and Grzegorz Tokarczyk. "Lycopene in the Prevention of Cardiovascular Diseases”. International Journal of Molecular Sciences 23.4 (2022): 1957.
  9. Cheng Ho M., et al. “Lycopene and tomato and risk of cardiovascular diseases: A systematic review and meta-analysis of epidemiological evidence”. Critical Reviews in Food Science and Nutrition1 (2019): 141-158.
  10. Reboul, Emmanuelle. “Mechanisms of Carotenoid Intestinal Absorption: Where Do We Stand?”. Nutrients4 (2019): 838.
  11. Kopsell Dean and Kopsell David. “Carotenoids in Vegetables”. (2010): 645-662.
  12. Reboul Emmanuelle. “Absorption of vitamin A and carotenoids by the enterocyte: focus on transport proteins”. Nutrients9 (2013): 3563-3581.
  13. Quadro Loredana., et al. “Interplay between β-carotene and lipoprotein metabolism at the maternal-fetal barrier”. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids11 (2020): 158591.
  14. Milani Alireza., et al. “Carotenoids: biochemistry, pharmacology and treatment”. British Journal of Pharmacology 174,11 (2017): 1290-1324.
  15. Di Meo Sergio and Paola Venditti. “Evolution of the Knowledge of Free Radicals and Other Oxidants”. Oxidative Medicine and Cellular Longevity 2020 (2020): 9829176.
  16. Jena Atala Bihari., et al. “Cellular Red-Ox system in health and disease: The latest update”. Biomedicine and Pharmacotherapy = Biomedecine and Pharmacotherapie 162 (2023): 114606.
  17. Martemucci Giovanni., et al. "Free Radical Properties, Source and Targets, Antioxidant Consumption and Health”. Oxygen 2,2 (2022): 48-78.
  18. Bin-Jumah May Nasser., et al. “Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases”. Antioxidants (Basel, Switzerland)2 (2022): 232.
  19. Vinha Ana Ferreira., et al. “Organic versus conventional tomatoes: influence on physicochemical parameters, bioactive compounds and sensorial attributes”. Food and Chemical Toxicology 67 (2014): 139-144.
  20. Amorim Adriany das Graças Nascimento., et al. “Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting”. Antioxidants (Basel, Switzerland)2 (2022): 360.
  21. Tao Anqi., et al. “Effect of Lycopene on Oral Squamous Cell Carcinoma Cell Growth by Inhibiting IGF1 Pathway”. Cancer Management and Research 13 (2021): 723-732.
  22. Wang Ran., et al. “Lycopene Inhibits Epithelial-Mesenchymal Transition and Promotes Apoptosis in Oral Cancer via PI3K/AKT/m-TOR Signal Pathway”. Drug Design, Development and Therapy 14 (2020): 2461-2471.
  23. Inoue Takuro., et al. “Effects of lycopene intake on HDL-cholesterol and triglyceride levels: A systematic review with meta-analysis”. Journal of Food Science8 (2021): 3285-3302.
  24. Vinha Ana Ferreira., et al. “Pre-meal tomato (Lycopersicon esculentum) intake can have anti-obesity effects in young women?”. International Journal of Food Sciences and Nutrition8 (2014): 1019-1026.
  25. Haskell Marjorie J. “The challenge to reach nutritional adequacy for vitamin A: β-carotene bioavailability and conversion--evidence in humans”. The American Journal of Clinical Nutrition5 (2012): 1193S-203S.
  26. Castenmiller Jacqueline JM., et al. “β-Carotene Does Not Change Markers of Enzymatic and Nonenzymatic Antioxidant Activity in Human Blood”. The Journal of Nutrition12 (1999): 2162-2169.
  27. van het Hof K H., et al. “Influence of feeding different vegetables on plasma levels of carotenoids, folate and vitamin C. Effect of disruption of the vegetable matrix”. The British Journal of Nutrition 82,3 (1999): 203-212.
  28. Honda Masaki. “Application of E/Z-Isomerization Technology for Enhancing Processing Efficiency, Health-Promoting Effects, and Usability of Carotenoids: A Review and Future Perspectives”. Journal of Oleo Science 71,2 (2022): 151-165.
  29. Yang Cheng., et al. “Bioaccessibility, Cellular Uptake, and Transport of Astaxanthin Isomers and their Antioxidative Effects in Human Intestinal Epithelial Caco-2 Cells”. Journal of Agricultural and Food Chemistry47 (2017): 10223-10232.
  30. Nagao Akihiko “Bioavailability of dietary carotenoids: intestinal absorption and metabolism”. JARQ4 (2014): 385-391.
  31. Liu Xuan., et al. “Increasing Carotenoid Bioaccessibility from Yellow Peppers Using Excipient Emulsions: Impact of Lipid Type and Thermal Processing”. Journal of Agricultural and Food Chemistry38 (2015): 8534-8543.
  32. Story Erica N., et al. “An update on the health effects of tomato lycopene”. Annual Review of Food Science and Technology 1 (2010): 189-210.
  33. Bohn Torsten., et al. “Mechanistic aspects of carotenoid health benefits - where are we now?”. Nutrition Research Reviews2 (2021): 276-302.
  34. Tan Bee Ling and Mohd Esa Norhaizan. “Carotenoids: How Effective Are They to Prevent Age-Related Diseases?”. Molecules 9 (2019): 1801.
  35. Norbitt Claire F., et al. “Relationship between Habitual Intake of Vitamins and New-Onset Prediabetes/Diabetes after Acute Pancreatitis”. Nutrients7 (2022): 1480.
  36. Sousa Clara. “Anthocyanins, Carotenoids and Chlorophylls in Edible Plant Leaves Unveiled by Tandem Mass Spectrometry”. Foods 13 (2022): 1924.
  37. Kljak Kristina., et al. "Plant Carotenoids as Pigment Sources in Laying Hen Diets: Effect on Yolk Color, Carotenoid Content, Oxidative Stability and Sensory Properties of Eggs”. Foods 10.4 (2021): 721.
  38. European Commission. “European Union Register of Feed Additives pursuant to Regulation (EC) No 1831/2003”. Annex I: List of additives. Edition 10/2020 (288). (2019).
  39. Grashorn M. “Feed additives for influencing chicken meat and egg yolk color”. In: Handbook on Natural Pigments in Food and Beverages; Carle, R., Schweiggert, R., Eds.; Woodhead Publishing: Cambridge, UK, (2016): 283-302.
  40. Stachowiak Barbara and Piotr Szulc. “Astaxanthin for the Food Industry”. Molecules 9 (2021): 2666.
  41. Sluijs I., et al. “Dietary intake of carotenoids and risk of type 2 diabetes”. Nutrition, Metabolism, and Cardiovascular Diseases 4 (2015): 376-381.
  42. Grand View Research (2020).


Citation: Ana F Vinha.,et al. “A New Approach on Carotenoids: Classification; Bioavailability and Further Industrial Applications".Acta Scientific Nutritional Health 7.7 (2023): 23-31.


Copyright: © 2023 Ana F Vinha., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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