Ping Lin¹, Yung-Hsiang Lin¹, Yung-Kai Lin² and Chi-Fu Chiang¹

¹Research and Design Center, TCI CO., Ltd., Taipei, Taiwan ²Institute of Food Safety and Risk Management, National Taiwan Ocean University, Keelung, Taiwan and Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan and Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan.

*Corresponding Author: Chi-Fu Chiang, Research and Design Center, TCI CO., Ltd., Taipei, Taiwan..

Received: May 05, 2023; Published: May 13, 2023

Abstract

Levilactobacillus brevis (TCI988) is a probiotic known for improving gut health, enhancing the immune system, and reducing inflammation and improved sleep quality. The aim of this study was to investigate whether L. brevis increased deep sleep and improve stress. Neuro-2a cells were treated with TCI988 for 24 hours, and then examined mitochondrial activity and related melatonin genes. In addition, subjects analyzed the GABA concentration and sleep and stress status. TCI988 can increase neuronal cell mitochondrial activity by 33.4% compared to the mock, and increased the expression of SIRTs, TPH1, and DDC by about 1.3, 1.23, and 1.05-fold, respectively, compared to the mock. The serum GABA level of the subjects increased from 165.89 ng/mL to 217.9 ng/mL after consuming TCI988 for 4 weeks, and increased deep sleep time and improved stress. L. brevis showed promise as a natural remedy for improving sleep quality.

Keywords:Deep Sleep; GABA; Levilactobacillus brevis; Probiotics; Stress

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Citation

Citation: Chi-Fu Chiang., et al. “Levi Levilactobacillus brevis (TCI988) Supplementation Enhances Sleep Quality". Acta Scientific Nutritional Health 7.6 (2023): 37-43.

Copyright

Copyright: © 2023 Chi-Fu Chiang., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.