Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Research Article Volume 7 Issue 3

Mortality and Clinical Outcomes of Hospitalized COVID-19 Patients is Associated with Serum Concentrations of Selenium and Vitamin D

Reihane Taheri1,6, Hossein Faramarzi2,3, Maryam Ekramzadeh1*, Hadi Raeisi Shahraki4, Zahra Negarande5 and Siavash Babajafari1,5

1Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Community Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Health Behavior Science Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
5Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
6Metabolic and Cardiovascular Diseases Laboratory, Division of Human Nutrition, University of Alberta, Edmonton

*Corresponding Author: Maryam Ekramzadeh, Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Received: February 16, 2023; Published: March 01, 2023


Background: Coronavirus disease (COVID-19) has imposed serious effects on public health. The main defender against this viral inflammatory disease is the body’s immune system. Selenium and vitamin D as anti-inflammatory, immune-enhancing micronutrients could be beneficial in alleviating the worst outcomes of COVID-19.

Methods: One hundred hospitalized COVID-19 patients with saturation of oxygen (SpO2) < 94 were assessed. In the first day of admission to the hospital, serum selenium and 25-hydroxy vitamin D concentrations were measured. Other clinical outcomes, including lung involvement, length of hospital stay (LOS), C-reactive protein (CRP), SpO2, intubation, and gastrointestinal and neural symptoms were extracted from each patient’s medical record. Twenty-four-hour food recall was taken to evaluate the food intake of patients.

Results: Fifty-six percent of patients were 25-hydroxy vitamin D deficient, and 2 percent were selenium deficient. After adjusting for confounding variables, serum selenium was negatively associated with mortality (coefficient: -0.16, p-value: 0.01) and both selenium (coefficient: -0.10, p-value: 0.01) and 25-hydroxy vitamin D (coefficient: -0.11, p-value: 0.004) showed inverse correlation with LOS.

Conclusion: There is an inverse association between serum concentrations of selenium and 25-hydroxy vitamin D with adverse clinical outcomes and mortality of patients with severe COVID-19. Higher concentrations of selenium were associated with increased SpO2 and decreased LOS and risk of death. Although higher concentrations of 25-hydroxy vitamin D were associated with reduced LOS and percentage of lung involvement, no association was found regarding mortality

Keywords: Selenium; Vitamin D; COVID-19; Lung Involvement; Mortality


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Citation: Maryam Ekramzadeh., et al. “Mortality and Clinical Outcomes of Hospitalized COVID-19 Patients is Associated with Serum Concentrations of Selenium and Vitamin D".Acta Scientific Nutritional Health 7.4 (2023): 04-15.


Copyright: © 2023 Maryam Ekramzadeh., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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