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Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Mini Review Volume 7 Issue 3

Obesity and Mutations in Mc4r and Mc3r

Mercedes Dejuán Bitriá*

Department of Nutrition Health, Spain

*Corresponding Author: Mercedes Dejuán Bitriá, Department of Nutrition Health, Spain.

Received: January 25, 2023; Published: February 26, 2023

Abstract

Obesity is a multisystemic disease of great importance in global public health as it is one of the major risk factors for comorbidities such as type 2 diabetes mellitus, cardiovascular disease or cancer. Several studies looking for the aetiology of this disease relate several external and internal factors to the development of the disease. Genetics has been shown to be an individual-specific factor with a broad effect on the development of obesity. There is a rs17782313 polymorphism in homozygous MC4R that has shown increased hyperphagia and hyperinsulinemia, leading to early obesity. In turn, the heterozygous mutation shows milder forms of obesity with increased weight gain in response to large amounts of fat in the diet, thus inferring a dose-gene effect [1]. Another polymorphism with a similar condition but still under investigation is the MC3R receptor mutation. The various alternatives to solve this disease allude to weight loss through a combination of physical exercise and the search for early satiety. It is clear that the treatment of these patients must be both individual and comprehensive to address all the predisposing and developmental factors of the disease [2]. For this reason, the aim of the study is deepening in this little-known disease and name some of the dietary interventions used to handle the effects of the mutation.

Keywords:Obesity; Overweight; Polymorphism; MC3R; MC4R

References

  1. Ulloa María Eugenia., et al. “Obesidad monogénica”. Medicinal Infant (2017): 294-302.
  2. Yilmaz Zeynep., et al. “Association between MC4R rs17782313 polymorphism and overeating behaviors”. International Journal of Obesity1 (2015): 114-120.
  3. Barragán Arnal Rocío. "Estudio de los factores del estilo de vida, genéticos y epigenéticos, que influyen en la obesidad y enfermedades relacionadas en población mediterránea”. Tesis. (2017).
  4. de Jesús Peralta-Romero., et al. “Genética de la obesidad infantil”. Revista Médica Del Instituto Mexicano Del Seguro Social1 (2014): S78-S87.
  5. de Eguilaz., et al. “Influencia multisensorial sobre la conducta alimentaria: ingesta hedónica”. Endocrinología, Diabetes y Nutrición2 (2018): 114-125.
  6. González Jiménez., et al. “Obesidad monogénica humana: papel del sistema leptina-melanocortina en la regulación de la ingesta de alimentos y el peso corporal en humanos”. Anales del sistema sanitario de Navarra Gobierno de Navarra. Departamento de Salud 35.2 (2012).
  7. Rachmi Cut Novianti., et al. “Stunting, underweight and overweight in children aged 2.0-4.9 years in Indonesia: prevalence trends and associated risk factors”. PloS one5 (2016): e0154756.
  8. Magno., et al. “Association of the MC4R rs17782313 polymorphism with plasma ghrelin, leptin, IL6 and TNFα concentrations, food intake and eating behaviors in morbidly obese women”. Eating and Weight Disorders-Studies on Anorexia, Bulimia and Obesity4 (2021): 1079-1087.
  9. Santos José Luis. "Sistema leptina-melanocortinas en la regulación de la ingesta y el peso corporal”. Revista Médica De Chile9 (2009): 1225-1234.
  10. Quesada Fabiana Vilma., et al. “Polimorfismos genéticos implicados en la predisposición a obesidad infantil”. (2013).
  11. Tremblay Angelo and France Bellisle. "Nutrients, satiety, and control of energy intake”. Applied Physiology, Nutrition, and Metabolism10 (2015): 971-979.
  12. Yarizadeh Habib., et al. “The interaction between the dietary inflammatory index and MC4R gene variants on cardiovascular risk factors”. Clinical Nutrition2 (2021): 488-495.
  13. Martos-Moreno Gabriel Á., et al. “Aspectos genéticos de la obesidad”. Revista Española Endocrinología Pediátrica 1 (2017): 21-32.
  14. Fani Lana., et al. “The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options”. International Journal of Obesity2 (2014): 163-169.
  15. Blundell JE., et al. “Appetite control and energy balance: impact of exercise”. Obesity Reviews16 (2015): 67-76.
  16. Brodowski Jacek., et al. “Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T> C) polymorphism of the MC4R gene in postmenopausal women”. Clinical Interventions in Aging12 (2017): 549.

Citation

Citation: Mercedes Dejuán Bitriá. “Obesity and Mutations in Mc4r and Mc3r".Acta Scientific Nutritional Health 7.3 (2023): 98-106.

Copyright

Copyright: © 2023 Mercedes Dejuán Bitriá. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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