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Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Mini Review Volume 7 Issue 3

Obesity and Mutations in Mc4r and Mc3r

Mercedes Dejuán Bitriá*

Department of Nutrition Health, Spain

*Corresponding Author: Mercedes Dejuán Bitriá, Department of Nutrition Health, Spain.

Received: January 25, 2023; Published: February 26, 2023


Obesity is a multisystemic disease of great importance in global public health as it is one of the major risk factors for comorbidities such as type 2 diabetes mellitus, cardiovascular disease or cancer. Several studies looking for the aetiology of this disease relate several external and internal factors to the development of the disease. Genetics has been shown to be an individual-specific factor with a broad effect on the development of obesity. There is a rs17782313 polymorphism in homozygous MC4R that has shown increased hyperphagia and hyperinsulinemia, leading to early obesity. In turn, the heterozygous mutation shows milder forms of obesity with increased weight gain in response to large amounts of fat in the diet, thus inferring a dose-gene effect [1]. Another polymorphism with a similar condition but still under investigation is the MC3R receptor mutation. The various alternatives to solve this disease allude to weight loss through a combination of physical exercise and the search for early satiety. It is clear that the treatment of these patients must be both individual and comprehensive to address all the predisposing and developmental factors of the disease [2]. For this reason, the aim of the study is deepening in this little-known disease and name some of the dietary interventions used to handle the effects of the mutation.

Keywords:Obesity; Overweight; Polymorphism; MC3R; MC4R


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Citation: Mercedes Dejuán Bitriá. “Obesity and Mutations in Mc4r and Mc3r".Acta Scientific Nutritional Health 7.3 (2023): 98-106.


Copyright: © 2023 Mercedes Dejuán Bitriá. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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