Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Review Article Volume 7 Issue 3

Contribution of Micronutrients to Boost the Immunity: “We Contribute for Human’s Healthy Life”

Srilatha Bashetti*

Associate Professor, Department of Biochemistry, Dr. Patnam Mahender Reddy Institute of Medical Sciences, India

*Corresponding Author: Srilatha Bashetti, Associate Professor, Department of Biochemistry, Dr. Patnam Mahender Reddy Institute of Medical Sciences, India.

Received: January 23, 2023; Published: February 06, 2023

Abstract

Worldwide the leading cause for mortality and morbidity is widespread of viral infections. Well established public health practice to reduce the spread and severity of infections is by regular and timely vaccination, proper hygene and sanitization, etc., however, proper and sufficient nutrition is highly recommended to build-up an optimal immune function to fight against the infections and reduce its effect on the health of an individual. The micro-nutrients like vitamins and minerals help in supporting the immune system, contributing increase resistance to infections caused by various viruses. The aim of the review article is to throw a light of knowledge regarding the role of micronutrients and stating its importance to maintain a good health and quality of life. COVID-19, had explaind the importance of micronutrients and their role in reducing the burgen of infectious diseases. The article tries to give a public note and recommend every individual to have sufficient/optimal nutrion with supplementation of omega -3 fatty acids and all the other micronutrients to establish a strong immune system against infections and lead a healthy and fit life.

Keywords: Micronutrients; Boost; Immunity

References

  1. World Health Organization. Global tuberculosis report 2019. Geneva, WHO (2019).
  2. El-Aziz TMA and Stockand JD. “Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2)-An update on the status”. Infection, Genetics and Evolution 83 (2020): 104327.
  3. Chen N., et al. “Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study”. Lancet 395 (2020): 507-513.
  4. Zhu J., et al. “Clinical characteristics of 3062 COVID-19 patients: A meta-analysis”. Journal of Medical Virology 92 (2020): 1902-1914.
  1. Wintergerst ES., et al. “Contribution of selected vitamins and trace elements to immune function”. Annals of Nutrition and Metabolism 5 (2007): 301-323.
  2. Iovino L., et al. “High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naïve lymphocytes and prevents TTV reactivation”. Leukemia Research 70 (2018): 20-24.
  3. Ivory K., et al. “Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults”. Clinical Nutrition 36 (2017): 407-415.
  4. Curtis LJ., et al. “Costs of hospital malnutrition”. Clinical Nutrition 36 (2017): 1391-1396.
  5. Bold J., et al. “Nutrition, the digestive system and immunity in COVID-19 infection”. Gastroenterology and Hepatology from Bed to Bench 13 (2020): 331-340.
  6. Calder PC., et al. “Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections”. Nutrients 12 (2020): 1181.
  7. Calder PC. “Nutrition, immunity and COVID-19”. BMJ Nutrition, Prevention and Health 3 (2020): 74-92.
  8. Bhaskaram P. “Immunobiology of mild micronutrient deficiencies”. British Journal of Nutrition 85 (2001): S75-S80.
  9. Fedele D., et al. “Obesity, malnutrition, and trace element deficiency in the coronavirus disease (COVID-19) pandemic: An overview”. Nutrition 81 (2021): 111016.
  1. Zhu N., et al. “A Novel Coronavirus from Patients with Pneumonia in China”. The New England Journal of Medicine 382 (2019): 727-733.
  2. Gombart AF., et al. “A review of micronutrients and the immune system-working in harmony to reduce the risk of infection”. Nutrients12 (2020): 236.
  3. Katona P and Katona-Apte J. “The interaction between nutrition and infection”. Clinical Infectious Diseases 46 (2008): 1582-1588.
  4. Imdad A., et al. “Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age”. Cochrane Database of Systematic Reviews 3 (2017).
  5. Hester GZ., et al. “Low use of vitamin A in children hospitalized for measles in the United States”. The Pediatric Infectious Disease Journal 39 (2020): e45-e46.
  6. Strebel PM., et al. “Measles”. The New England Journal of Medicine 381 (2019): 349-357.
  7. Prasad R., et al. “Serum retinol, vitamin D and zinc levels in under five children with acute lower respiratory tract infections”. Indian Journal of Pediatrics 86 (2019): 196-197.
  8. Kyran PQ and Karen CH. “Vitamin A and respiratory syncytial virus infection: Serum level and supplementation trial”. Archives of Pediatrics and Adolescent Medicine 150 (1996): 25-30.
  9. Dowell SF., et al. “Treatment of respiratory syncytial virus infection with vitamin A: A randomized placebo-controlled trial in Santiago, Chile”. The Pediatric Infectious Disease Journal 15 (1996): 782-786.
  10. Bresee JS., et al. “Vitamin A therapy for children with respiratory syncitial virus infection: A multicenter trial in the United States”. The Pediatric Infectious Disease Journal 15 (1996): 777-782.
  11. Fawzi WW., et al. “Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania”. The Journal of Pediatrics 137 (2000): 660-667.
  12. Imdad A., et al. “Impact of vitamin a supplementation on infant and childhood mortality”. BMC Public Health 11 (2011): S20.
  13. Mathew JL. “Vitamin A supplementation for prophylaxis or therapy in childhood pneumonia: A systematic review of randomized controlled trials”. Indian Pediatrics 47 (2010): 255-261.
  14. Sasidharan NV., et al. “Vitamin C facilitates demethylation of the Foxp3 enhancer in a Tet-dependent manner”. The Journal of Immunology 196 (2016): 2119-2131.
  15. Constantini NW., et al. “The effect of vitamin C on upper respiratory infections in adolescent swimmers: A randomized trial”. European Journal of Pediatrics 170 (2011): 59-63.
  16. Ran L., et al. “Extra Dose of Vitamin C Based on a Daily Supplementation Shortens the Common Cold: A Meta-Analysis of 9 Randomized Controlled Trials”.               BioMed Research International 2018 (2018): 1837634.
  17. Diao B., et al. “Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19)”. Frontiers in Immunology 11 (2020): 827.
  18. Janssen R., et al. “Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes”. The Journal of Infectious Diseases 196 (2007): 826-834.
  19. Roth DE., et al. “Vitamin D receptor polymorphisms and the risk of acute lower respiratory tract infection in early childhood”. The Journal of Infectious Diseases 197 (2008): 676-680.
  20. Gubatan J., et al. “Cathelicidin Mediates a Protective Role of Vitamin D in Ulcerative Colitis and Human Colonic Epithelial Cells”. Inflammatory Bowel Disease 26 (2020): 885-897.
  21. Wehkamp J., et al. “Defensins and other antimicrobial peptides in inflammatory bowel disease”. Current Opinion in Gastroenterology 23 (2007): 370-378.
  22. de Jong MD., et al. “Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Version 2”. Nature Medicine 12 (2006): 1203-1207.
  23. Ye Q., et al. “The pathogenesis and treatment of the ‘Cytokine Storm’ in COVID-19”. Journal of Infection 80 (2020): 607-613.
  24. Tufan A., et al. “COVID-19, immune system response, hyperinflammation and repurposing anti-rheumatic drugs”. Turkish Journal of Medical Sciences 50.SI-1 (2020): 620-632.
  25. Zhao M. “Cytokine storm and immunomodulatory therapy in COVID-19: Role of chloroquine and anti-IL-6 monoclonal antibodies”. International Journal of Antimicrobial Agents 55 (2020): 105982.
  26. Henderson LA., et al. “On the alert for cytokine storm: Immunopathology in COVID-19”. Arthritis Rheumatology 77 (2020): 1059-1063.
  27. Muhe L., et al. “Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children”. Lancet 349 (1997): 1801-1804.
  28. Wayse V., et al. “Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5y”. European Journal of Clinical Nutrition 58 (2004): 563-567.
  29. Banajeh SM. “Nutritional rickets and vitamin D deficiency--association with the outcomes of childhood very severe pneumonia: A prospective cohort study”. Pediatric Pulmonology 44 (2009): 1207-1215.
  30. Roth DE., et al. “Vitamin D status is notassociated with the risk of hospitalization for acute bronchiolitis in early childhood”. European Journal of Clinical Nutrition 63 (2009): 297-299.
  31. Haider N., et al. “Frequency of nutritional rickets in children admitted with severe pneumonia”. Journal of Pakistan Medical Association 60 (2010): 729-732.
  32. Oduwole AO., et al. “Relationship between vitamin D levels and outcome of pneumonia in children”. West African Journal of Medicine 29 (2010): 373-378.
  33. Leis KS., et al. “Vitamin D intake in young children with acute lower respiratory infection”. Translational Pediatrics 1 (2012): 6-14.
  34. Beigelman A., et al. “Vitamin D Levels Are Unrelated to the Severity of Respiratory Syncytial Virus Bronchiolitis Among Hospitalized Infants”. Journal of the Pediatric Infectious Diseases Society 4 (2015): 182-188.
  35. Narang GS., et al. “Association of Vitamin D Deficiency with Acute Lower Respiratory Infection in Toddlers”. Journal of Nepal Paediatric Society 36 (2016): 14-18.
  36. Xu C., et al. “Serum 25-Hydroxyvitamin D Was Not Associated with Influenza Virus Infection in Children and Adults in Hong Kong, 2009-2010”. The Journal of Nutrition 146 (2016): 2506-2512.
  37. Erol M., et al. “The Effect of Vitamin D Deficiency on the Severity of Bronchiolitis in Infants”. The Journal of Pediatric Research 4 (2017): 12-16.
  38. Vo P., et al. “Vitamin D Status at the Time of Hospitalization for Bronchiolitis and Its Association with Disease Severity”. The Journal of Pediatrics 203 (2018): 416-422.
  39. Ilie PC., et al. “The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality”. Aging Clinical and Experimental Research 32 (2020): 1195-1198.
  40. D’Avolio A., et al. “25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2”. Nutrients 12 (2020): 1359.
  41. Lau FH., et al. “Vitamin D Insufficiency is Prevalent in Severe COVID-19”. MedRxiv (2020).
  42. Finamore A., et al. “Zinc deficiency induces membrane barrier damage and increases neutrophil transmigration in Caco-2 cells”. The Journal of Nutrition 138 (2008): 1664-1670.
  43. Bao S and Knoell DL. “Zinc modulates cytokine-induced lung epithelial cell barrier permeability”. The American Journal of Physiology-Lung Cellular and Molecular Physiology 291 (2006): L1132-L1141.
  44. Roscioli E., et al. “Zinc deficiency as a codeterminant for airway epithelial barrier dysfunction in an ex vivo model of COPD”. International Journal of Chronic Obstructive Pulmonary Disease 12 (2017): 3503-3510.
  45. Science M., et al. “Zinc for the treatment of the common cold: A systematic review and meta-analysis of randomized controlled trials”. CMAJ 184 (2012): E551-E561.
  46. Kar M., et al. “Zinc Chelation Specifically Inhibits Early Stages of Dengue Virus Replication by Activation of NF-κB and Induction of Antiviral Response in Epithelial Cells”. Frontiers in Immunology 10 (2019): 2347.
  47. TeVelthuis AJ., et al. “Zn (2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture”. PLOS Pathogens 6 (2010): e1001176.
  48. Kar M., et al. “Zinc Chelation Specifically Inhibits Early Stages of Dengue Virus Replication by Activation of NF-κB and Induction of Antiviral Response in Epithelial Cells”. Frontiers in Immunology 10 (2019): 2347.
  49. Osendarp SJ., et al. “Effect of zinc supplementation between 1 and 6 mo of life on growth and morbidity of Bangladeshi infants in urban slums”. The American Journal of Clinical Nutrition 76 (2002): 1401-1408.
  50. Baqui AH., et al. “Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: Community randomised trial”. BMJ 325 (2002): 1059.
  51. Baqui AH., et al. “Simultaneous weekly supplementation of iron and zinc is associated with lower morbidity due to diarrhea and acute lower respiratory infection in Bangladeshi infants”. The Journal of Nutrition 133 (2003): 4150-4157.
  52. Brooks WA., et al. “Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: Randomised controlled trial”. Lancet 366 (2005): 999-1004.
  53. Sazawal S., et al. “Effect of zinc supplementation on mortality in children aged 1-48 months: A community-based randomised placebo-controlled trial”. Lancet 369 (2007): 927-934.
  54. Malik A., et al. “Zinc supplementation for prevention of acute respiratory infections in infants: A randomized controlled trial”. Indian Pediatrics 51 (2014): 780-784.
  55. Roth DE., et al. “Zinc supplementation for the prevention of acute lower respiratory infection in children in developing countries: Meta-analysis and meta-regression of randomized trials”. International Journal of Epidemiology 39 (2010): 795-808.
  56. Lassi ZS., et al. “Zinc supplementation for the prevention of pneumonia in children aged 2 months to 59 months”. Cochrane Database of Systematic Reviews 12 (2016): CD005978.
  57. Castillo ME., et al. “Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study”. The Journal of Steroid Biochemistry and Molecular Biology 203 (2020): 105751.
  58. Basil MC and Levy BD. “Specialized pro-resolving mediators: Endogenous regulators of infection and inflammation”. Nature Reviews Immunology 16 (2016): 51-67.
  59. Imhoff-Kunsch B., et al. “Prenatal docosahexaenoic acid supplementation and infant morbidity: Randomized controlled trial”. Pediatrics 128 (2011): e505-e512.
  60. Pastor N., et al. “Infants fed docosahexaenoic acid- and arachidonic acid-supplemented formula have decreased incidence of bronchiolitis/bronchitis the first year of life”. Clinical Pediatrics 45 (2006): 850-855.
  61. Atwell K., et al. “Respiratory hospitalisation of infants supplemented with docosahexaenoic acid as preterm neonates”. Journal of Paediatrics and Child Health 49 (2013): E17-E22.
  62. Mehta P., et al. HLH Across Speciality Collaboration, UK. “COVID-19: Consider cytokine storm syndromes and immunosuppression”. Lancet 395 (2020): 1033-1034.
  63. Thienprasert A., et al. “Fish oil n-3 polyunsaturated fatty acids selectively affect plasma cytokines and decrease illness in Thai schoolchildren: A randomized, double-blind, placebo-controlled intervention trial”. The Journal of Pediatrics 154 (2009): 391-395.
  64. Rice TW., et al. NIH NHLBI Acute Respiratory Distress Syndrome Network of Investigators. “Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury”. JAMA 306 (2011): 1574-1581.
  65. Stapleton RD., et al. “A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury”. Critical Care Medicine 39 (2011): 1655-1662.
  66. Dushianthan A., et al. “Immunonutrition for acute respiratory distress syndrome (ARDS) in adults”. Cochrane Database of Systematic Reviews 1 (2019): CD012041.

Citation

Citation: Srilatha Bashetti. “Contribution of Micronutrients to Boost the Immunity: “We Contribute for Human’s Healthy Life”".Acta Scientific Nutritional Health 7.3 (2023): 30-36.

Copyright

Copyright: © 2023 Srilatha Bashetti. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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Impact Factor1.316

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