A Trap of RCT in Low Protein Dietary Therapy. Revaluation of
Pro-Post Study for Dietary Intervention
Tokyo University of Agriculture, Medical Rice Association, Tokyo
*Corresponding Author: Shaw Watanabe, Tokyo University of Agriculture, Medical Rice Association, Tokyo.
November 28, 2022; Published: December 06, 2022
The current trend of clinical research in the medical world, which highly evaluates “evidence-based medicine” only with the RCT methodology, is expected to be seriously reconsidered by those involved. What is important is the scientific truth and the patient’s life, and it is essential in dietary therapy for CKD.
- Volhard F. “Die doppelseitigen hamatogenen Nierenkrankungen (Bright'sche Krankheit)”. Mohr, Stachelin (eds) Handbuch der Inneren Menshen. Berlin, Springer (1918): 1149-1172.
- Giordano C. “The use of exogenous and endogenous urea for protein synthesis in normal and uremic subjects”. Journal of Laboratory and Clinical Medicine 62 (1963): 231-235.
- Giovannetti S and Maggiore Q. “A low-nitrogen diet with protein of high biological for severe chronic uremia”. Lancet 283 (1964): 1000-1004.
- Rosman JB., et al. “Prospective randomized trial of early dietary protein restriction in chronic renal failure”. Lancet 324 (1984): 1291-1296.
- Menon V., et al. “Effect of a very low-protein diet on outcomes: long-term follow-up of the Modification of Diet in Renal Disease (MDRD) Study”. American Journal of Kidney Diseases 2 (2009): 208-217.
- Ideura T., et al. “Protein intake of more than 0.5g/kg BW/day is not effective in suppressing the progression of chronic renal failure”. Contributions to Nephrology 155 (2007): 40-49.
- Locatelli F., et al. “Prospective, randomised, multicentre trial of effect of protein restriction on progression of chronic renal insufficiency. Northern Italian Cooperative Study Group”. Lancet 8753 (1991): 1299-1304.
- Klahl S., et al. “The effects of dietary protein restriction and blood-pressure control on the progression of chronic renaldisease. Modification of Diet in Renal Disease Study Group”. The New England Journal of Medicine 13 (1994): 877-884.
- GUIDANCE FOR PRE- and POST-TEST DESIGN.
- Watanabe S., et al. “Dietary therapy with low protein genmai (brown rice) to improve the gut-kidney axis and reduce CKD progression”. Asia Pacific Journal of Clinical Nutrition 3 (2022): 341-347.