An Update on Role of Curcumin in Colorectal Cancer-A Minireview
Kulvinder Kaur*, Gautam NK Allahbadia
Scientific Director, Ex-Rotunda-A Centre for Human Reproduction, Mumbai, India
*Corresponding Author: Kulvinder Kaur, Scientific Director, Ex-Rotunda-A Centre for Human Reproduction, Mumbai, India.
October 25, 2022; Published: November 18, 2022
Earlier we had reviewed the part of curcumin as an anti-oxidant, anti-inflammatory, neuro shielding, anticancer, hapatoprotecting, as well as cardio shielding actions. Further its bioavailability issues, bio effectiveness as well as safety parameters along with quality properties of Curcumin were further tackled, besides its role in PCOS. Here we tried to concentrate on the part of curcumin in Colorectal cancer (CRC). Diffusion of curcumin takes place via the cell membrane into the cell membrane endoplasmic reticulum (ER), mitochondria along with nucleus where its anti-oxidant characteristics get impacted. Hence its utilization has been recommended regarding chemopreventive, antimetastatic along with anti-angiogenic uses. Thus we conducted a minireview review on role on CRC with the utilization of search engines like PubMed, google scholar, web of science, Cochrane library from 1995 till date in 2022 with the utilization of MeSH terms like Curcumin; antioxidant actions; other anti-inflammatory actions; anti angiogenic actions; CRC; chemopreventive actions; ER stress; familial adenomatous polyposis (FAP); in vivo studies in animal models; in vitro studies. We found 2500 articles but selected only 53 articles for this review with the journals constraints of upto 50 references. No meta-analysis was done. In vitro studies conducted on human colon cancer cell lines illustrated that Curcumin hampered growth via cell cycle arrest at the G2/M along with G1 phase, besides crosstalk with numerous molecular targets. In vivo studies were conducted in mice having inflammatory along with genetic CRC in animal models possessing a chemopreventive action. regarding enhancement of bioavailability, it has been correlated with small particles that escalate its absorption on oral delivery with great outcomes in both inflammation as well as carcinogenesis. Furthermore curcumin utilization has been done in dietary formulation for CRC chemoprevention. These illustrated that in vitro along with in vitro anti carcinogenic characteristics in inflammatory along with genetic CRC.A synergestic action was pointed on utilization of unique dosages of the component that was lesser in contrast to experimentally utilized for single component. Thus with favourable actions in animal models, good scope of their working in humans preclinical studies.
Keywords: Curcumin; CRC; Animal Models; Apoptosis; Cellular Culture
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