Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Research Article Volume 6 Issue 11

Probiotics: Modulator of Human Health and Potential Fighter against Coronavirus Pandemic

Rafia Sameen1* and Sidra Moqaddes2

1Department of Animal Genomics and Biotechnology, PIASA, National Agricultural Research Centre (NARC), Islamabad, Pakistan

2Faculty of Veterinary Medicine, University of Calgary, Canada

*Corresponding Author: Rafia Sameen, Department of Animal Genomics and Biotechnology, PIASA, National Agricultural Research Centre (NARC), Islamabad, Pakistan.

Received: September 06, 2022; Published: October 04, 2022


Digestive tract of human is rich in bacterial microflora which not only protects the intestine from pathogenic microorganisms but also provide beneficial substances e.g., Vitamin B12 and lactic acid which are helpful in metabolism. In some individuals, microflora could not develop properly which result in recurrent infections, suppressed immune system, disturbed gut-brain axis leading to neural disorders in some severe cases. Probiotics are the microorganisms which impart health benefits if administered in appropriate amount. They have potential to improve gut-brain barrier thus reducing the chances of nervous system disorders like anxiety and depression. Pro-apoptotic and anti-proliferative activity of probiotics has also demonstrated on human gastric and colorectal cancerous cells. Modulation of probiotics can be helpful to prevent colorectal cancer which has ranked to be third major types of cancers prevalent in developing countries. SARS CoV-2, the responsible factor of current Coronavirus pandemic requires Angiotensin Converting Enzyme 2 (ACE-2) as receptor for infection which is digestion related enzyme of human enterocytes. Expression of viral receptors can be elevated in invasive bacterial infections such as Salmonella enterica infecting small intestine, however healthy gut with proper dose of probiotics can help prevent such infections and indirectly the chances of Coronavirus infection by reducing the expression of ACE-2. Interleukin-17 associated endoplasmic reticulum stress induced in Coronavirus infection can also be reduced by some Bifidobacterium strains which have inhibitory effects against IL-17. Other probiotic microorganisms include Saccharomyces spp., Lactobacillus spp., Enterococcus spp. and Streptococcus spp. which are added in different food products like yogurt, curd, cheese and processed meat to stimulate metabolism.

Keywords: Gut-Brain Axis; Probiotics; SARS CoV-2; Interleukin-17


  1. Behnsen J., et al. “Probiotics: properties, examples, and specific applications”. Cold Spring Harbor Perspectives in Medicine 3.3 (2013): a010074.
  2. Hooper., et al. “Commensal host-bacterial relationships in the gut”. Science 292.5519 (2001): 11151118.
  3. DiBaise John K., et al. “Gut microbiota and its possible relationship with obesity”. Mayo Clinic Proceedings. Elsevier 83.4. (2008).
  4. Gill Steven R., et al. “Metagenomic analysis of the human distal gut microbiome”. Science 312.5778 (2006): 1355-1359.
  5. Backhed F., et al. “Host-bacterial mutualism in the human intestine”. Science 307.5717 (2005): 1915-


  1. Louis P., et al. “The gut microbiota, bacterial metabolites and colorectal cancer”. Nature Reviews Microbiology 12.10 (2014): 661-672.
  2. Musso G., et al. “Obesity, diabetes, and gut microbiota. The hygiene hypothesis expanded?” Diabetes Care 33.10 (2010): 2277-2284.
  3. LeBlanc JG., et al. “Bacteria as vitamin suppliers to their host: a gut microbiota perspective”. Current Opinion in Biotechnology 24.2 (2013): 160-168.
  4. Martens J-H., et al. “Microbial production of vitamin B12”. Applied Microbiology and Biotechnology 58.3 (2002): 275-285.
  5. Pompei A., et al. “Folate production by bifidobacteria as a potential probiotic property”. Applied and Environmental Microbiology 73.1 (2007): 179-185.
  6. Thursby E and Nathalie J. "Introduction to the human gut microbiota”. Biochemical Journal 474.11 (2017): 1823-1836.
  7. FAO/WHO. “Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria” (2001).
  8. Plaza-Diaz J., et al. “Mechanisms of action of probiotics”. Advances in Nutrition 10.1 (2019): S49S6.
  9. Plaza-Díaz J., et al. “Immune-mediated mechanisms of action of probiotics and synbiotics in treating pediatric intestinal diseases”. Nutrients 10.1 (2018): 42.
  10. Mendes MCS., et al. “Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice”. World Journal of Gastroenterology 24.18 (2018): 1995.
  11. Cryan JF and Timothy GD. "Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour”. Nature Reviews Neuroscience 13.10 (2012): 701-712.
  12. Daulatzai MA. "Non-celiac gluten sensitivity triggers gut dysbiosis, neuroinflammation, gut-brain axis dysfunction, and vulnerability for dementia”. CNS and Neurological Disorders-Drug Targets (Formerly Current Drug      Targets-CNS        and Neurological Disorders 14.1 (2015): 110-131.
  13. Carabotti M., et al. “The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems”. Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology 28.2 (2015): 203.
  14. Zhou L. and Jane A.F. "Psychobiotics and the gut–brain axis: in the pursuit of happiness”. Neuropsychiatric Disease and Treatment 11 (2015): 715.
  15. Ait-Belgnaoui A., et al. “Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats”. Psychoneuroendocrinology 37.11 (2012): 1885-


  1. Sherwin E., et al. “A gut (microbiome) feeling about the brain”. Current Opinion in Gastroenterology 32.2 (2016): 96-102.
  2. Bercik P., et al. “Microbes and the gut‐brain axis”. Neurogastroenterology and Motility 24.5 (2012): 405413.
  3. Clapp M., et al. “Gut microbiota’s effect on mental health: The gut-brain axis”. Clinics and Practice 7.4 (2017): 987.
  4. Mayer EA., et al. “Altered brain‐gut axis in autism: comorbidity or causative mechanisms?”. Bioessays 36.10 (2014): 933-939.
  5. Dinan TG., et al. “Psychobiotics: a novel class of psychotropic”. Biological Psychiatry 74.10 (2013): 720-726.
  6. Fooks LJ and Glenn RG. "Probiotics as modulators of the gut flora”. British Journal of Nutrition 88.S1

(2002): s39-s49.

  1. Lee JW., et al. “Immunomodulatory and antitumor effects in vivo by the cytoplasmic fraction of Lactobacillus casei and Bifidobacterium longum”. Journal of Veterinary Science 5.1 (2004): 41-48.  
  2. Parkin   DM. "International variation”. Oncogene 23.38 (2004): 6329-6340.
  3. Parkin DM., et al. “Cancer burden in the year 2000. The global picture”. European Journal of Cancer

37 (2001): 4-66.  

  1. Crew KD and Alfred IN. "Epidemiology of gastric cancer”. World Journal of Gastroenterology:WJG 12.3 (2006): 354.
  2. Stewart Bernard W and Paul K. “World Cancer Report” 57. Lyon: IARC press (2003).
  3. DeBarros M., and Scott R. Steele. "Colorectal cancer screening in an equal access healthcare system”. Journal of Cancer 4.3 (2013): 270.
  4. Azcárate-Peril M., et al. “The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer?" American Journal of Physiology-Gastrointestinal and Liver Physiology 301.3 (2011): G401-G424.
  5. Commane D., et al. “The potential mechanisms involved in the anti-carcinogenic action of probiotics”. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 591.1-2 (2005): 276-289.
  6. Ambalam P., et al. “Probiotics, prebiotics and colorectal cancer prevention”. Best Practice and Research Clinical Gastroenterology 30.1 (2016): 119-131.
  7. Kim Y., et al. “Inhibition of proliferation in colon cancer cell lines and harmful enzyme activity of colon bacteria by Bifidobacterium adolescentis SPM0212”. Archives of Pharmacal Research 31.4 (2008): 468-473.
  8. Russo F., et al. “Effects of Lactobacillus rhamnosus GG on the cell growth and polyamine metabolism in HGC-27 human gastric cancer cells”. Nutrition and Cancer 59.1 (2007): 106-114.
  9. Orlando A., et al. “Effects of Lactobacillus rhamnosus GG on proliferation and polyamine metabolism in HGC-27 human gastric and DLD-1 colonic cancer cell lines”. Immunopharmacology and Immunotoxicology 31.1 (2009): 108-116.
  10. Orlando A., et al. “Antiproliferative and proapoptotic effects of viable or heat-killed Lactobacillus paracasei IMPC2. 1 and Lactobacillus rhamnosus GG in HGC-27 gastric and DLD-1 colon cell lines”. Nutrition and Cancer 64.7 (2012): 1103-1111.
  11. Yu Ai-Qun and Lianqin L. "The potential role of probiotics in cancer prevention and treatment”. Nutrition and Cancer 68.4 (2016): 535-544.
  12. Cousin FJ., et al. “Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells”. PloS One 7.3 (2012): e31892.
  13. Chen Y., et al. “Emerging coronaviruses: genome structure, replication, and pathogenesis”. Journal of Medical Virology 92.4 (2020): 418-423.
  14. Lai Chih-Cheng., et al. “Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges”. International Journal of Antimicrobial Agents 55.3 (2020): 105924.
  15. Pal M., et al. “Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): an update”. Cureus 12.3 (2020).
  16. Bozkurt Hüseyin S. "Probiotic bacteria against the COVID-19”. OSF Preprints (2020).
  17. Yu L., et al. “Immunodepletion with hypoxemia: a potential high risk subtype of coronavirus disease 2019”. MedRxiv (2020).
  18. Feng Z., et al. “The small intestine, an underestimated site of SARS-CoV-2 infection: from red queen effect to probiotics”. Preprints (2020).
  19. Di Stadio A., et al. “Nutraceuticals as immune-stimulating therapy to fight COVID-19. Combination of elements to improve the efficacy”. European Review for Medical and Pharmacological Sciences 24 (2020): 9182-9187.
  20. Rocha-Ramírez, L.M., et al. “Probiotic Lactobacillus strains stimulate the inflammatory response and activate human macrophages”. Journal of Immunology Research 2017 (2017).
  21. Della Volpe A., et al. “The effects of oral supplements with Sambucus nigra, Zinc, Tyndallized Lactobacillus acidophilus (HA122), Arabinogalactans, vitamin D, vitamin E and vitamin C in otitis media with effusion in children: A randomized controlled trial”. European Review for Medical and Pharmacological Sciences 23.14 (2019): 6360-6370.
  22. Prado Acosta Mariano., et al. “Surface (S) layer proteins of Lactobacillus acidophilus block virus infection via DC-SIGN interaction”. Frontiers in Microbiology 10 (2019): 810.
  23. Lee Jong-Soo., et al. “Mucosal immunization with surface-displayed severe acute respiratory syndrome coronavirus spike protein on Lactobacillus casei induces neutralizing antibodies in mice”. Journal of Virology 80.8 (2006): 4079-4087.
  24. et al. “Nutrition in the elderly: an opportunity for nursing care”. univ (2017).


Citation: Rafia Sameen and Sidra Moqaddes. “Probiotics: Modulator of Human Health and Potential Fighter against Coronavirus Pandemic". Acta Scientific Nutritional Health 6.11 (2022): 19-25.


Copyright: © 2022 Rafia Sameen and Sidra Moqaddes. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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