Rafia Sameen¹* and Sidra Moqaddes²

¹Department of Animal Genomics and Biotechnology, PIASA, National Agricultural Research Centre (NARC), Islamabad, Pakistan

²Faculty of Veterinary Medicine, University of Calgary, Canada

*Corresponding Author: Rafia Sameen, Department of Animal Genomics and Biotechnology, PIASA, National Agricultural Research Centre (NARC), Islamabad, Pakistan.

Received: September 06, 2022; Published: October 04, 2022

Abstract

Digestive tract of human is rich in bacterial microflora which not only protects the intestine from pathogenic microorganisms but also provide beneficial substances e.g., Vitamin B12 and lactic acid which are helpful in metabolism. In some individuals, microflora could not develop properly which result in recurrent infections, suppressed immune system, disturbed gut-brain axis leading to neural disorders in some severe cases. Probiotics are the microorganisms which impart health benefits if administered in appropriate amount. They have potential to improve gut-brain barrier thus reducing the chances of nervous system disorders like anxiety and depression. Pro-apoptotic and anti-proliferative activity of probiotics has also demonstrated on human gastric and colorectal cancerous cells. Modulation of probiotics can be helpful to prevent colorectal cancer which has ranked to be third major types of cancers prevalent in developing countries. SARS CoV-2, the responsible factor of current Coronavirus pandemic requires Angiotensin Converting Enzyme 2 (ACE-2) as receptor for infection which is digestion related enzyme of human enterocytes. Expression of viral receptors can be elevated in invasive bacterial infections such as Salmonella enterica infecting small intestine, however healthy gut with proper dose of probiotics can help prevent such infections and indirectly the chances of Coronavirus infection by reducing the expression of ACE-2. Interleukin-17 associated endoplasmic reticulum stress induced in Coronavirus infection can also be reduced by some Bifidobacterium strains which have inhibitory effects against IL-17. Other probiotic microorganisms include Saccharomyces spp., Lactobacillus spp., Enterococcus spp. and Streptococcus spp. which are added in different food products like yogurt, curd, cheese and processed meat to stimulate metabolism.

Keywords: Gut-Brain Axis; Probiotics; SARS CoV-2; Interleukin-17

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Citation

Citation: Rafia Sameen and Sidra Moqaddes. “Probiotics: Modulator of Human Health and Potential Fighter against Coronavirus Pandemic". Acta Scientific Nutritional Health 6.11 (2022): 19-25.

Copyright

Copyright: © 2022 Rafia Sameen and Sidra Moqaddes. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.