Tart Cherry Juice Reduces Plasma Triglycerides and CVD Risk Factor, But Does not Affect
Indirect Measures of Insulin Resistance, in Overweight and Obese Subjects: A Randomized,
Crossover Pilot Study
Keith R Martin1*, Jennifer Bopp2 and Lacey Burrell2
1Center for Nutraceutical and Dietary Supplement Research, University of Memphis, Tennessee, United States
2Healthy Lifestyles Research Center, Arizona State University, Phoenix, AZ, United States
*Corresponding Author: Keith R Martin, Center for Nutraceutical and Dietary Supplement Research, University of Memphis, Tennessee, United States.
July 29, 2022; Published: August 23, 2022
Background: Cardiovascular disease (CVD) is the leading cause of death for men and women globally in both developed and developing countries, thus is a significant health problem. Obesity and overweightness (BMI ≥ 25 kg/m2), occurring in 67% of the U.S. population, and insulin insensitivity (pre-diabetes) are co-morbidities frequently occurring concomitantly with CVD. Accumulating epidemiological evidence shows that polyphenol-rich diets rich in fruits can significantly reduce CVD risk.
Methods: In this randomized, placebo-controlled crossover pilot study, we recruited 10 participants (38.1 ± 12.5 y; 9 females, 2 males) with BMI > 25.0 (32.2 ± 4.6 kg/m2; 5 obese, 5 overweight) to consume 8 fl oz. daily of either 100% tart cherry juice (TCJ) or an alternate placebo beverage, for 4 weeks each with a 2-week intervening washout period. Fasting blood samples were collected at the beginning and end of each arm for measurement of biomarkers of dyslipidemia and glycemia.
Results: Total cholesterol (TC) was not different between treatments (p > 0.05) but plasma triglycerides (TG) and the CVD risk factor ratio TG/HDL-C were statistically decreased 10% and 17%, respectively (p < 0.05) after TCJ consumption. A trend existed for VLDL, which was reduced 15%. LDL-C and HDL-C were not different between treatments. Baseline fasting glucose (FG) and insulin levels were 99 ± 7 mg/dl and 12.8 ± 5.8 uIU/ml, respectively, with half having FG > 100 mg/dL. HOMA, QUICKI, and McAuley indices of insulin resistance were modulated suggesting pre-diabetes, but values were not significantly different between groups at study completion.
Conclusion: Collectively, the data suggest that 100% TCJ can reduce CVD risk by reducing plasma TG and some routinely used risk factors. ratios
Keywords: Tart Cherry Juice; Metabolic Syndrome; Insulin Resistance; Triglycerides; Overweight/Obese
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