Zahrau Muhammad Kabir¹* and Muhammad Ibrahim Usman²

¹Department of Education Biology, Yobe State University, Damaturu, Yobe State, Nigeria
²Department of Biochemistry, College of Medical Sciences, Yobe State University Damaturu, Nigeria

*Corresponding Author: Zahrau Muhammad Kabir, Department of Education Biology Yobe State University, Damaturu, Yobe State, Nigeria.

Received: July 05, 2022; Published: August 05, 2022

Abstract

This research investigates anti-hyperlipidemic ability of solvents extracts of Adensonia digitata fruits pulps in diet induced hyperlipidemic rats. Rats were induced with hyperlipoidemia by administration of high lipid enriched feeds for a period of 6 weeks. A total of thirty-six albino rats were used for the study, they were placed into six groups of six rats each. Group one and two were normal control and positive control group respectively, while group three, four, five and six were induced with hyperlipidemia and administered with 250 mg/kg of each extract (i.e., n- hexane, chloroform, ethyl acetate and residue) respectively. Two weeks after extract administration, the rats were sacrificed and blood samples were collected for biochemical analysis. Significant increase (p < 0.05) in the serum TC, TG, and LDL-C were observed in hyperlipidemic control rats compared to normal control. After extracts administration, a significant decrease (P < 0.05) in TC, LDL–C, TG was observed in ethyl acetate administered group compared to other extract and hyperlipidemic control groups. The study demonstrated that ethyl acetate extract Adansonia digitata fruit pulp extract possesses strong anti-hyperlipidemic bio active compound. Sub-chronic toxicity of the active ethyl acetate extract reveals no toxicity on liver and kidney tissues. Further researches on the extract should dwell on isolation and characterization bioactive compound (s).

Keywords: Adansonia digitata; Fruit pulp; Hyperlipidemia; Lipid profile; Kidney and Liver

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Citation

Citation: Zahrau Muhammad Kabir and Muhammad Ibrahim Usman. “Antihyperlipidemic Studies of Solvents Extract of Adansonia Digitata Fruit Pulps". “Antihyperlipidemic Studies of Solvents Extract of Adansonia Digitata Fruit Pulps". Acta Scientific Nutritional Health 6.9 (2022): 16-21.

Copyright

Copyright: © 2022 Zahrau Muhammad Kabir and Muhammad Ibrahim Usman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.