Greice Dotto Simoes¹*, Roberta Giorgi¹, Caina Correa do Amaral¹, Camila Perello Ferrua¹, Geovanna Peter Correa¹, Tiago Fernandez Garcia¹, Amanda de Lima Aldrighi², Karoline Brizola de Souza², Aline Longoni dos Santos¹, Adriano Martimbianco de Assis¹, Priscila Marques Moura de Leon³, Fernanda Nedel¹

¹Research Group on Cellular and Molecular Biotechnology Applied to Health (GPCell), Graduate Program in Health and Behavior, Catholic University of Pelotas, Brazil
²Graduate Program in Health and Behavior, Catholic University of Pelotas, Brazil
³Equine Genomics Research Group - GenE, Nucleus of Biotechnology, Technological Development Center, Federal University of Pelotas, Brazil

*Corresponding Author: Fernanda Nedel, Research Group on Cellular and Molecular Biotechnology Applied to Health (GPCell), Graduate Program in Health and Behavior, Catholic University of Pelotas, Brazil.

Received: May 31, 2022; Published: July 29, 2022

This study aimed to systematically review the literature to identify the effects of KB in animal models of diabetes induction. A search was carried out in the following databases: PubMed, Scopus, Scielo, ScienceDirect, and ISI Web of Knowledge, using the descriptors “(Kombucha [MeSH])” and “(Kombucha tea [MeSH])”. From the articles found, two independent and previously calibrated reviewers, using the EndNote X7 (Thomson Reuters, New York, US), selected those that investigated the effects of KB in animal models of diabetes induction. Of the 1214 studies found, 7 were included in the systematic review. All studies used male rats and induced diabetes with alloxan or streptozotocin. The most prevalent substrate applied in the KB fermentation was sweetened black tea (BT). The included studies focused on biochemical analysis, mainly in markers for diabetes (glucose, insulin and glycated hemoglobin), lipid profile, antioxidant molecules, and histological analyses of the pancreas and the liver, demonstrating a reverse in damages caused by the chemical induction of diabetes in animal models. In this study, a panel of KB effects in parameters altered by diabetes induction in rats was created, which could contribute to understanding the benefits of KB administration.

Keywords: Kombucha; Polyphenols; Antioxidant; Animal Model; Diabetes Induction; Systematic Review

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Citation

Citation: Greice Dotto Simoes., et al. “Effects of Kombucha in Diabetes Induced Animal Models: A Systematic Review".Acta Scientific Nutritional Health 6.8 (2022): 121-134.

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Copyright: © 2022 Greice Dotto Simoes., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.