Abstract

Vitamin K possesses numerous significant role in human health. More recently researchers have a established that healthy diet consumption possessing good fats, Vitamins, minerals, polyphenolics possesses anti-inflammatory actions can act in antiaging role. Earlier the belief was that Vitamin K acts basically as an anticoagulant, besides part in calcium homeostasis. Having reviewed the etiology in chronic kidney disease (CKD), Diabetic Kidney Disease (DKD)with those patients presenting with DKD- CKD or end stage renal Disease (ESRD), in addition to details of associated Vascular calcification, acute kidney injury here we tried to further update knowledge regarding role of Vitamin K deficit in deterioration of CKD in particular the ones associated with Vascular calcification (VC). Vitamin K plays a significant role as a co- factor in transformation of glutamate to Gla. This has a significance in hampering of VC. CKD patients both on dialysis as well as not on dialysis generally possess Vitamin K deficiency. Enhancement of uncarboxylated matrix Gla protein [MGP] (uc MGP) indirectly points to Vitamin K deficiency as well as correlated with a greater chance of generation of the cardiovascular processes. It has been pointed that greater Vitamin K consumption might cause avoidance of development of VC, besides reduction in CV risk. Thus we did a minireview utilizing the search engine pubmed, google scholar and other sutilizing the MeSH terms like DKD; CKD; Vitamin K ; Growth arrest specific protein 6 (Gas6); VC; hemodialysis (HD) patients from 2000 till date in 2022. We found s total of 65 articles with regards to CKD, Vitamin K, out of which we chose50 articles for this minireview. Despite all the research till date role of supplementation of Vitamin K with dosage, kinds still not clear that is varying from country to country as well as source VK1 or2. Still greater large RCTs are required to settle that query.

Keywords: Vitamin K; uc MGP; CKD; VK Supplementation; VC; Gas61

References

Citation

Citation: Kulvinder Kochar Kaur., et al. “An Update on Etiology of Chronic Kidney Disease with Role of Associated Vitamin K Deficiency in Prevention of Vascular Calcification and Cardiovascular Risks and Avoid Mortality: A Minireview".Acta Scientific Nutritional Health 6.5 (2022): 82-91.

Copyright

Copyright: © 2022 Kulvinder Kochar Kaur., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.