Tahseen Bilal Rather, Gulzar Ahmad Bhat and Syed Mudassar*

Professor and Head of the Department of Biochemistry, Sher-i- Kashmir Institute of Medical Sciences, Srinagar, India

*Corresponding Author:Syed Mudassar, Professor and Head of the Department of Biochemistry, Sher-i- Kashmir Institute of Medical Sciences, Srinagar, India.

Received: March 22, 2022; Published: April 11, 2022

Abstract

Objectives: Inadequate iodine intake has a profound adverse impact on a child's developmental behaviour. The study’s aim was to ascertain the median urinary iodine concentration (mUIC) and the prevalence of iodine deficiency, as well as to understand whether maternal characteristics have an effect on iodine status in Kashmiri pregnant women.

Study Design: Prospective study

Methods: A total of 112 pregnant women subjects were enrolled in this study from the Department of gynaecology and obstetrics, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar. UIC was calculated using a modified Sandell-Kolthoff reaction. The World Health Organization classification was established as a suggested cut off value of 150 µg/L to categorise the iodine status of pregnant women.

Results: All the 112 recruited subjects in their first trimester, were initially examined for goitre status. The mUIC was 80.91 (interquartile range (IQR): 49.2-116.47)μg/L. In our study 80 (71.4%) study subjects were from rural areas. 101 pregnant women (90%) had UIC < 150µg/L (insufficient), 8(7.14%) had UIC of 150-250µg/L(normal) and only 3(2.67%) study subjects had UIC of > 250µg/L(excess). Significantly higher UIC was present in the younger population having age ≤ 25 years (104 µg/L), as well as in urban subjects (117.38µg/ L) and in subjects without goitre (87.85µg/ L). The goitre prevalence was 37.5%. It was 7-fold more common in illiterate subjects as compared to literate (OR = 7.14, 95%CI:2.94-17.37). Similarly rural pregnant women were at 2-fold more risk than urban for goitre occurrence (OR = 2.39,95%CI:1.03-5.51). Likewise, income status of the study participants was significantly associated with UIC (p < 0.027). UIC also showed a weak negative correlation with age (r = -.265, p = 0.005)

Conclusion: This research concludes that there is a mild to moderate iodine deficiency in pregnant mothers and thus a broad and representative sample of Kashmiri pregnant women is needed to assess iodine status at the population level.

Keywords: Kashmir; Median Urinary Iodine Concentration; Pregnant Women; 1^st Trimester

References

1. Karakochuk CD., et al. “Median Urinary Iodine Concentrations Are Indicative of Adequate Iodine Status among Women of Reproductive Age in Prey Veng, Cambodia”. Nutrients 3 (2016): 139.
2. Hetzel BS. “Towards the global elimination of brain damage due to iodine deficiency-the role of the International Council for Control of Iodine Deficiency Disorders”. International Journal of Epidemiology 4 (2005): 762-764.
3. Yadav K and Pandav CS. “National Iodine Deficiency Disorders Control Programme: Current status and future strategy”. Indian Journal of Medical Research 5 (2018): 503-510.
4. Ramalingaswami V. “The problem of goitre prevention in India”. Bulletin of the World Health Organization 2 (1953): 275-281.
5. Mehta M., et al. “Intellectual assessment of school children from severely iodine deficient villages”. Indian Pediatr 6 (1987): 467-473.
6. Upadhyay SK., et al. “Developmental lag in preschool children of goitrous mothers”. Indian Pediatr 4 (1983): 259-263.
7. Kochupillai N., et al. “Iodine deficiency and neonatal hypothyroidism”. Bulletin of the World Health Organization 4 (1986): 547-551.
8. Redman K., et al. “Iodine Deficiency and the Brain: Effects and Mechanisms”. Critical Reviews in Food Science and Nutrition 16 (2016): 2695-2713.
9. Zimmermann MB and Andersson M. “Assessment of iodine nutrition in populations: past, present, and future”. Nutrition Reviews 10 (2012): 553-570.
10. World Health O. “Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers”. 3rd edition edition. Geneva: World Health Organization (2007).
11. Gordon RC., et al. “Iodine supplementation improves cognition in mildly iodine-deficient children”. The American Journal of Clinical Nutrition 5 (2009): 1264-1271.
12. Bath SC and Rayman MP. “A review of the iodine status of UK pregnant women and its implications for the offspring”. Environmental Geochemistry and Health 4 (2015): 619-629.
13. Zimmermann MB. “The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review”. Thyroid 9 (2007): 829-835.
14. Bleichrodt N and Born MP. A metaanalysis of research on iodine and its relationship to cognitive development (1996).
15. Bhutta ZA., et al. “Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost?” Lancet 9890 (2013): 452-477.
16. Pandav CS., et al. “Iodine deficiency disorders (IDD) control in India”. The Indian Journal of Medical Research 3 (2013): 418.
17. Andersson M., et al. “Global iodine status in 2011 and trends over the past decade”. The Journal of Nutrition 4 (2012): 744-750.
18. Rohner F., et al. “Biomarkers of nutrition for development-iodine review”. The Journal of Nutrition 8 (2014): 1322S-1342S.
19. Dunn JT., et al. “Two simple methods for measuring iodine in urine”. Thyroid 2 (1993): 119-123.
20. Delange F., et al. “Iodine deficiency during infancy and early childhood in Belgium: does it pose a risk to brain development?” European Journal of Pediatrics 4 (2001): 251-254.
21. Andersen SL., et al. “Iodine deficiency in Danish pregnant women”. Danish Medical Journal 7 (2013): A4657.
22. Granfors M., et al. “Iodine deficiency in a study population of pregnant women in Sweden”. Acta Obstetricia et Gynecologica Scandinavica 11 (2015): 1168-1174.
23. Lindorfer H., et al. “Iodine deficiency in pregnant women in Austria”. European Journal of Clinical Nutrition 3 (2015): 349-354.
24. Zygmunt A., et al. “An assessment of the effectiveness of iodine prophylaxis in pregnant women-analysis in one of reference gynaecological-obstetric centres in Poland”. Endokrynologia Polska 5 (2015): 404-411.
25. Majumder A., et al. “Prevalence of iodine deficiency among pregnant and lactating women: experience in Kolkata”. Indian Journal of Endocrinology and Metabolism 4 (2014): 486.
26. Chakraborty I., et al. “Iodine deficiency disorders among the pregnant women in a rural hospital of West Bengal”. Indian Journal of Medical Research 6 (2006): 825.
27. Boyages SC., et al. “A comparative study of neurological and myxedematous endemic cretinism in western China”. The Journal of Clinical Endocrinology and Metabolism 6 (1988): 1262-1271.
28. Boyages SC., et al. “Iodine deficiency impairs intellectual and neuromotor development in apparently‐normal persons: A study of rural inhabitants of north‐central China”. Medical Journal of Australia 12 (1989): 676-682.
29. Ganaie MA., et al. “Maternal overt hypothyroidism and neurobehavioral outcome of neonates: a cohort study from an iodine-deficient area of Northern India”. Indian Pediatrics 10 (2015): 864-866.
30. Zargar AH., et al. “Prevalence of goitre in school children in Baramulla (Kashmir valley)”. The Indian Journal of Pediatrics 2 (1997): 225-230.
31. Zargar A., et al. “Goiter survey in school children in Kupwara (Kashmir Valley)”. Indian Pediatrics 3 (1996): 248-249.
32. Fereja M., et al. “Prevalence of iodine deficiency and associated factors among pregnant women in Ada district, Oromia region, Ethiopia: a cross-sectional study”. BMC Pregnancy and Childbirth 1 (2018): 1-8.
33. Khattak RM., et al. Regional Influences on Nutritional Iodine Status of Pregnant Women in Pakistan 28.11 (2018): 1538-1546.
34. Shahid M., et al. Prevalence and incidence of thyroid disorder during pregnancy in Bangladesh-a tertiary care hospital based study 11.1 (2021).
35. Beer RJ., et al. “Median Urinary Iodine Concentration in Colombian Children and Women is High and Related to Sociodemographic and Geographic Characteristics: Results from a Nationally Representative Survey”. The Journal of Nutrition 4 (2021): 940-948.
36. Endalamaw ., et al. “Visible Goiter among Pregnant Women Attending Antenatal Clinic in Public Health Facilities of Debre Markos Town, East Gojjam, North West Ethiopia”. Journal of Nutrition and Metabolism (2019).
37. Pelala NB., et al. “Maternal and neonatal iodine status in Dakshina Kannada district of Karnataka, India”. Sudanese Journal of Paediatrics 1 (2020): 20.
38. Rana R and Raghuvanshi RS. “Effect of different cooking methods on iodine losses”. Journal of Food Science and Technology 6 (2013): 1212-1216.

Citation

Citation: Syed Mudassar., et al. The Median Urinary Iodine Concentrations among Pregnant Women of Kashmir are Indicative of Insufficient Iodine Status".Acta Scientific Nutritional Health 6.5 (2022): 40-45.

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Copyright: © 2022 Syed Mudassar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.