The Median Urinary Iodine Concentrations among Pregnant Women of
Kashmir are Indicative of Insufficient Iodine Status
Tahseen Bilal Rather, Gulzar Ahmad Bhat and Syed Mudassar*
Professor and Head of the Department of Biochemistry, Sher-i- Kashmir Institute
of Medical Sciences, Srinagar, India
*Corresponding Author:Syed Mudassar, Professor and Head of the Department of
Biochemistry, Sher-i- Kashmir Institute of Medical Sciences, Srinagar, India.
March 22, 2022; Published: April 11, 2022
Objectives: Inadequate iodine intake has a profound adverse impact on a child's developmental behaviour. The study’s aim was to ascertain the median urinary iodine concentration (mUIC) and the prevalence of iodine deficiency, as well as to understand whether maternal characteristics have an effect on iodine status in Kashmiri pregnant women.
Study Design: Prospective study
Methods: A total of 112 pregnant women subjects were enrolled in this study from the Department of gynaecology and obstetrics, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar. UIC was calculated using a modified Sandell-Kolthoff reaction. The World Health Organization classification was established as a suggested cut off value of 150 µg/L to categorise the iodine status of pregnant women.
Results: All the 112 recruited subjects in their first trimester, were initially examined for goitre status. The mUIC was 80.91 (interquartile range (IQR): 49.2-116.47)μg/L. In our study 80 (71.4%) study subjects were from rural areas. 101 pregnant women (90%) had UIC < 150µg/L (insufficient), 8(7.14%) had UIC of 150-250µg/L(normal) and only 3(2.67%) study subjects had UIC of > 250µg/L(excess). Significantly higher UIC was present in the younger population having age ≤ 25 years (104 µg/L), as well as in urban subjects (117.38µg/ L) and in subjects without goitre (87.85µg/ L). The goitre prevalence was 37.5%. It was 7-fold more common in illiterate subjects as compared to literate (OR = 7.14, 95%CI:2.94-17.37). Similarly rural pregnant women were at 2-fold more risk than urban for goitre occurrence (OR = 2.39,95%CI:1.03-5.51). Likewise, income status of the study participants was significantly associated with UIC (p < 0.027). UIC also showed a weak negative correlation with age (r = -.265, p = 0.005)
Conclusion: This research concludes that there is a mild to moderate iodine deficiency in pregnant mothers and thus a broad and representative sample of Kashmiri pregnant women is needed to assess iodine status at the population level.
Keywords: Kashmir; Median Urinary Iodine Concentration; Pregnant Women; 1st Trimester
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