Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Short Communication Volume 6 Issue 3

Take Another Look at Antioxidants

Leonard W Heflich*

Innovation for Success, LLC, USA

*Corresponding Author: Leonard W Heflich, Innovation for Success, USA.

Received: January 27, 2022; Published: February 11, 2022

Antioxidants are molecules that are capable of donating an electron or accepting a proton from an unstable free radical molecule. Free radicals have an extra unpaired electron, making them very unstable, highly reactive and therefore dangerous. Early forms of life had to develop a mechanism for neutralizing free radicals in order to avoid the damage they cause. Studies of early bacteria have discovered the presence of antioxidants at least 2.5 billion years ago. Exposure to atmospheric oxygen and sunlight would not be possible without antioxidants to neutralize the free radicals produced. Anerobic bacteria never learned the trick and even today must hide underground or deep in the ocean where sunlight and oxygen cannot reach.


  1. Tan Dun-Xian. “Mitochondria and Chloroplasts as the Original Sites of Melatonin Synthesis: A Hypothesis Related to Melatonin’s Primary Function and Evolution in Eukaryotes”. Journal of Pineal Research 54 (2013): 127-138.
  2. Manchester Lucien C. “Melatonin: An Ancient Molecule That Makes Oxygen Metabolically Tolerable”. Journal of Pineal Research 59 (2015): 403-419.
  3. Arnao Marino B. “Functions of Melatonin in Plants: A Review”. Journal of Pineal Research 59 (2015): 133-150.
  4. Ferlazzo Nadia. “Is Melatonin the Cornucopia of the 21st Century”. Antioxidants 9 (2020): 1088.
  5. Tan Dun-Xian. “Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism”. Molecules 20 (2015): 18886-18906.
  6. Rusanova Iryna. “Protective Effects of Melatonin on the Skin: Future Perspectives”. International Journal of Molecular Sciences 20 (2019).
  7. Bora Nilutpal Sharma. “Protective Effect of a Topical Sunscreen Formulation Fortified with Melatonin against UV-Induced Photodermatitis: An Immunomodulatory Effect via NF-KB Suppression”. Immunopharmacology and Immunotoxicology (2019).
  8. Warraich Umm-e-Ammara. “Aging - Oxidative Stress, Antioxidants and Computational Modeling”. Heliyon 6 (2020): e04107.
  9. Jin, Seon-Pil. “Urban Particulate Matter in Air Pollution Penetrates into the Barrier-Disrupted Skin and Produces ROS-Dependent Cutaneous Inflammatory Response in Vivo”. Journal of Dermatological Science 91 (2018): 175-183.
  10. Rendra Erika. “Reactive Oxygen Species (ROS) in Macrophage Activation and Function in Diabetes”. Immunobiology 224 (2019): 242-253.
  11. Alberti George. “Introduction to the Metabolic Syndrome”. European Heart Journal Supplements0205AD D3-5.
  12. Spahis Schohraya. “Oxidative Stress as a Critical Factor in Nonalcoholic Fatty Liver Disease Pathogenesis”. Antioxidants and Redox Signaling10 (2017): 519-542.
  13. Mathys Leen. “The Role of Cellular Oxidoreductases in Viral Entry and Virus Infection-Associated Oxidative Stress: Potential Therapeutic Applications”. Expert Opinion on Therapeutic Targets 20, no. 1 (July 15, 2015): 123-143.
  14. Yuen Chun-Kit. “SARS-CoV-2 Nsp13, Nsp14, Nsp15 and Orf6 Function as Potent Interferon Antagonists”. Emerging Microbes and Infections 9 (2020): 1418-1428.
  15. Yang Lan. “The Signal Pathways and Treatment of Cytokine Storm in COVID-19”. Signal Transduction and Targeted Therapy 6 (2021): 255.
  16. Poljsak Borut. “Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants”. Oxidative Medicine and Cellular Longevity (2013):956792.
  17. Poltorak, Alexander. “Cell Death and Cytokine Storms" How Your Body’s Innate Immune Response Is Crucial to Battling COVID-19”. The Conversation (2020).


Citation: Leonard W Heflich. “Take Another Look at Antioxidants". Acta Scientific Nutritional Health 6.3 (2022): 35-37.


Copyright: © 2022 Leonard W Heflich. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.316

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is April 30th, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US