Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Review Article Volume 6 Issue 3

Bioactivity, Bioavailability and Bioaccessibility of Blackcurrant Anthocyanins: An Updated Comprehensive Review

Ruiting Li1, Chunmin Yang1, Bin Xue1, Xiaodan Hui2, Xin Shao2*and Gang Wu2*

1School of Engineering, Guangzhou College of Technology and Business, Guangzhou, China
2Department of Critical Care Medicine, Maoming People’s Hospital, Maoming, Guangdong, China

*Corresponding Author: Xin Shao and Gang Wu, Department of Critical Care Medicine, Maoming People’s Hospital, Maoming, Guangdong, China.

Received: January 17, 2022; Published: February 10, 2022

Abstract

Blackcurrant-based products are trending worldwide as potential functional foods consumed for diseases prevention. Blackcurrant is recognized as its abundant sources of bioactive compounds and dietary fiber. The phenolic compounds, especially proanthocyanins and anthocyanins existing in blackcurrant berry fruit, have been extensively studied by the scientific community for their various medicinal values. The benefits of the anthocyanins are associated with their free-radical scavenging capacity. Anthocyanins must be available or removed from the blackcurrant matrix and then bioaccessible in the gastrointestinal system and must pass through metabolism to the targeted tissue for this capability in humans or animals. This review was focused on the anthocyanin metabolism from the blackcurrant, including the bioavailability, bioaccessibility, and bioactivity, by summarizing factors affecting phytochemical profiles of blackcurrant-based products, including growing and processing and biokinetics of blackcurrant anthocyanins. Assessment of bioaccessibility and bioavailability of blackcurrant anthocyanin is important for understanding its limitations on absorption and functions of blackcurrant anthocyanin towards human nutrition.

Keywords: Anthocyanin; Bioavailability; Blackcurrant; Phenolic Compounds; Functional Foods

References

  1. Abreu IN., et al. “Quantitative trait loci mapping of polyphenol metabolites in blackcurrant (Ribes nigrum L.)”. Metabolomics 16 (2020): 23.
  2. Allwood JW., et al. “Application of HPLC-PDA-MS metabolite profiling to investigate the effect of growth temperature and day length on blackcurrant fruit”. Metabolomics 15 (2019): 17.
  3. Angelino D., et al. “Bioaccessibility and bioavailability of phenolic compounds in bread: a review”. Food and Function 8 (2017): 2368-2393.
  4. Archaina D., et al. “Physical and functional properties of spray-dried powders from blackcurrant juice and extracts obtained from the waste of juice processing”. Food Science and Technology International 24 (2018): 78-86.
  5. Azman EM., et al. “Effect of dehydration on phenolic compounds and antioxidant activity of blackcurrant (Ribes nigrum L.) pomace”. International Journal of Food Science and Technology 56 (2020): 600-607.
  6. Bakowska-Barczak AM and Kolodziejczyk PP. “Black currant polyphenols: Their storage stability and microencapsulation”. Industrial Crops and Products 34 (2011): 1301-1309.
  7. Basegmez HIO., et al. “Biorefining of blackcurrant pomace into high value functional ingredients using supercritical CO2, pressurized liquid and enzyme assisted extractions”. The Journal of Supercritical Fluids 124 (2017): 10-19.
  8. Bender C., et al. “Effect of mash enzyme and heat treatments on the cellular antioxidant activity of black currant (Ribes nigrum), raspberry (Rubus idaeus), and blueberry (Vaccinium myrtillus) juices”. CyTA - Journal of Food 15 (2017): 277-283.
  9. Bendokas V., et al. “Anthocyanins: From the Field to the Antioxidants in the Body”. Antioxidants 9 (2020): 819.
  10. Benn T., et al. “Polyphenol-rich blackcurrant extract exerts hypocholesterolaemic and hypoglycaemic effects in mice fed a diet containing high fat and cholesterol”. British Journal of Nutrition 113 (2015): 1697-1703.
  11. Bishayee A., et al. “Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats”. The Journal of Nutritional Biochemistry 22 (2011): 1035-1046.
  12. Blando F., et al. “Radical Scavenging and Anti-Inflammatory Activities of Representative Anthocyanin Groupings from Pigment-Rich Fruits and Vegetables”. International Journal of Molecular Sciences 19 (2018): 15.
  13. Braakhuis AJ., et al. “The effect of New Zealand blackcurrant on sport performance and related biomarkers: a systematic review and meta-analysis”. Journal of the International Society of Sports Nutrition 17 (2020): 10.
  14. Brenes CH., et al. “Stability of Copigmented Anthocyanins and Ascorbic Acid in a Grape Juice Model System”. Journal of Agricultural and Food Chemistry 53 (2005): 49-56.
  15. Brown EM., et al. “Persistence of Anticancer Activity in Berry Extracts after Simulated Gastrointestinal Digestion and Colonic Fermentation”. PLoS One 7 (2012): 10.
  16. Cao L., et al. “Long-Term Blackcurrant Supplementation Modified Gut Microbiome Profiles in Mice in an Age-Dependent Manner: An Exploratory Study”. Nutrients 12 (2020): 13.
  17. Carbonell-Capella JM., et al. “Quality parameters, bioactive compounds and their correlation with antioxidant capacity of commercial fruit-based baby foods”. Food Science and Technology International 20 (2014): 479-487.
  18. Castro-Acosta ML., et al. “Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations”. Journal of Nutritional Biochemistry 38 (2016): 154-161.
  19. Castro-Acosta ML., et al. “Apple and blackcurrant polyphenol-rich drinks decrease postprandial glucose, insulin and incretin response to a high-carbohydrate meal in healthy men and women”. The Journal of Nutritional Biochemistry 49 (2017): 53-62.
  20. Castro-Acosta ML., et al. “Apple and blackcurrant polyphenol-rich drinks decrease postprandial glucose, insulin and incretin response to a high-carbohydrate meal in healthy men and women”. Journal of Nutritional Biochemistry 49 (2017): 53-62.
  21. Charron CS., et al. “Bioavailability of Anthocyanins from Purple Carrot Juice: Effects of Acylation and Plant Matrix”. Journal of Agricultural and Food Chemistry 57 (2009): 1226-1230.
  22. Cook MD., et al. “Cardiovascular function during supine rest in endurance-trained males with New Zealand blackcurrant: a dose-response study”. European Journal of Applied Physiology 117 (2017): 247-254.
  23. Cook MD., et al. “Cardiovascular function during supine rest in endurance-trained males with New Zealand blackcurrant: a dose–response study”. European Journal of Applied Physiology 117 (2017): 247-254.
  24. Cook MD., et al. “Dose effects of New Zealand blackcurrant on substrate oxidation and physiological responses during prolonged cycling”. European Journal of Applied Physiology 117 (2017): 1207-1216.
  25. Cook MD., et al. “Blackcurrant Alters Physiological Responses and Femoral Artery Diameter during Sustained Isometric Contraction”. Nutrients 9 (2017): 14.
  26. Cortez RE., et al. “Blackcurrants (Ribes nigrum): A Review on Chemistry, Processing, and Health Benefits”. Journal of Food Science 84 (2019): 2387-2401.
  27. Cristani M., et al. “Protective activity of an anthocyanin-rich extract from bilberries and blackcurrants on acute acetaminophen-induced hepatotoxicity in rats”. Natural Product Research 30 (2016): 2845-2849.
  28. Crozier A., et al. “Dietary phenolics: chemistry, bioavailability and effects on health”. Natural Product Reports 26 (2009): 1001-1043.
  29. David SG., et al. “Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries”. Carcinogenesis 29 (2008): 1665-1674.
  30. De Pascual-Teresa S and Sanchez-Ballesta MT. “Anthocyanins: from plant to health”. Phytochemistry Reviews 7 (2008): 281-299.
  31. De Rosso VV and Mercadante AZ. “The high ascorbic acid content is the main cause of the low stability of anthocyanin extracts from acerola”. Food Chemistry 103 (2007): 935-943.
  32. Declume C. “Anti-inflammatory evaluation op a hydroalcoholic extract op black currant leaves (Ribes nigrum)”. Journal of Ethnopharmacology 27 (1989): 91-98.
  33. Diaconeasa Z., et al. “Antiproliferative and Antioxidant Properties of Anthocyanin Rich Extracts from Blueberry and Blackcurrant Juice”. International Journal of Molecular Sciences 16 (2015): 2352-2365.
  34. Dima C., et al. “Bioavailability and bioaccessibility of food bioactive compounds; overview and assessment by in vitro methods”. Comprehensive Reviews in Food Science and Food Safety 19 (2020): 2862-2884.
  35. Drakou CE., et al. “Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode”. Journal of Agricultural and Food Chemistry 68 (2020): 10191-10199.
  36. Dreiseitel A., et al. “Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1”. British Journal of Pharmacology 158 (2009): 1942-1950.
  37. Espín JC., et al. “Nutraceuticals: Facts and fiction”. Phytochemistry 68 (2007): 2986-3008.
  38. Fan DW., et al. “Supplementation of Blackcurrant Anthocyanins Increased Cyclic Glycine-Proline in the Cerebrospinal Fluid of Parkinson Patients: Potential Treatment to Improve Insulin-Like Growth Factor-1 Function”. Nutrients 10 (2018): 11.
  39. Faria A., et al. “Absorption of anthocyanins through intestinal epithelial cells – Putative involvement of GLUT2”. Molecular Nutrition and Food Research 53 (2009): 1430-1437.
  40. Farooque S., et al. “Enhancing the Potential Exploitation of Food Waste: Extraction, Purification, and Characterization of Renewable Specialty Chemicals from Blackcurrants (Ribes nigrum L.)”. Journal of Agricultural and Food Chemistry 66 (2018): 12265-12273.
  41. Gagneten M., et al. “Spray-dried powders from berries extracts obtained upon several processing steps to improve the bioactive components content”. Powder Technology 342 (2019): 1008-1015.
  42. Gagneten M., et al. “Optimization of Pulsed Electric Field Treatment for the Extraction of Bioactive Compounds from Blackcurrant”. Food and Bioprocess Technology 12 (2019): 1102-1109.
  43. Garzón GA and Wrolstad RE. “Comparison of the Stability of Pelargonidin-based Anthocyanins in Strawberry Juice and Concentrate”. Journal of Food Science 67 (2002): 1288-1299.
  44. Godwin C., et al. “Effect of New Zealand Blackcurrant Extract on Performance during the Running Based Anaerobic Sprint Test in Trained Youth and Recreationally Active Male Football Players”. Sports 5 (2017): 10.
  45. Godwin C., et al. “Effect of New Zealand Blackcurrant Extract on Performance during the Running Based Anaerobic Sprint Test in Trained Youth and Recreationally Active Male Football Players”. Sports 5 (2017): 69.
  46. Gonçalves J., et al. “Assessment of the Bioaccessibility and Bioavailability of the Phenolic Compounds of Prunus avium L. by in Vitro Digestion and Cell Model”. ACS Omega 4 (2019): 7605-7613.
  47. Gu L., et al. “Concentrations of proanthocyanidins in common foods and estimations of normal consumption”. The Journal of Nutritional 134 (2004): 613-617.
  48. Han F., et al. “Digestion and absorption of red grape and wine anthocyanins through the gastrointestinal tract”. Trends in Food Science and Technology 83 (2019): 211-224.
  49. Hélder Oliveira., et al. “Comparison of the in vitro gastrointestinal bioavailability of acylated and non-acylated anthocyanins: Purple-fleshed sweet potato vs red wine”. Food Chemistry 276 (2018): 410-418.
  50. Hiles AM., et al. “Dietary supplementation with New Zealand blackcurrant extract enhances fat oxidation during submaximal exercise in the heat”. Journal of Science and Medicine in Sport 23 (2020): 908-912.
  51. Horie K., et al. “Phytoestrogenic Effects of Blackcurrant Anthocyanins Increased Endothelial Nitric Oxide Synthase (eNOS) Expression in Human Endothelial Cells and Ovariectomized Rats”. Molecules 24 (2019): 1259.
  52. Horie K., et al. “Phytoestrogenic Effects of Blackcurrant Anthocyanins Increased Endothelial Nitric Oxide Synthase (eNOS) Expression in Human Endothelial Cells and Ovariectomized Rats”. Molecules 24 (2019): 11.
  53. Huebbe P., et al. “Effects of blackcurrant-based juice on atherosclerosis-related biomarkers in cultured macrophages and in human subjects after consumption of a high-energy meal”. British Journal of Nutrition 108 (2012): 234-244.
  54. Hui X., et al. “The effects of bioactive compounds from blueberry and blackcurrant powders on the inhibitory activities of oat bran pastes against α-amylase and α-glucosidase linked to type 2 diabetes”. Food Research International 138 (2020): 109756.
  55. Hurst RD., et al. “Consumption of an Anthocyanin-Rich Extract Made From New Zealand Blackcurrants Prior to Exercise May Assist Recovery From Oxidative Stress and Maintains Circulating Neutrophil Function: A Pilot Study”. Frontiers in Nutrition 6 (2019): 14.
  56. Hurst RD., et al. “Daily Consumption of an Anthocyanin-Rich Extract Made From New Zealand Blackcurrants for 5 Weeks Supports Exercise Recovery Through the Management of Oxidative Stress and Inflammation: A Randomized Placebo Controlled Pilot Study”. Frontiers in Nutrition 7 (2020): 15.
  57. Iizuka Y., et al. “Blackcurrant Extract Ameliorates Hyperglycemia in Type 2 Diabetic Mice in Association with Increased Basal Secretion of Glucagon-Like Peptide-1 and Activation of AMP-Activated Protein Kinase”. Journal of Nutritional Science and Vitaminology 64 (2018): 258-264.
  58. Jaroslawska J., et al. “Protective effects of polyphenol-rich blackcurrant preparation on biochemical and metabolic biomarkers of rats fed a diet high in fructose”. Journal of Animal Physiology and Animal Nutrition 100 (2016): 136-145.
  59. Jarret DA., et al. “A Transcript and Metabolite Atlas of Blackcurrant Fruit Development Highlights Hormonal Regulation and Reveals the Role of Key Transcription Factors”. Frontiers in Plant Science 9 (2018): 22.
  60. Jurgonski A., et al. “Diet-induced disorders in rats are more efficiently attenuated by initial rather than delayed supplementation with polyphenol-rich berry fibres”. Journal of Functional Foods 22 (2016): 556-564.
  61. Jurgonski A., et al. “Polyphenol-rich extract from blackcurrant pomace attenuates the intestinal tract and serum lipid changes induced by a high-fat diet in rabbits”. European Journal of Nutrition 53 (2014): 1603-1613.
  62. Keppler K and Humpf H-U. “Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora”. Bioorganic and Medicinal Chemistry 13 (2005): 5195-5205.
  63. Khoo GM., et al. “Bioactivity and chemical composition of blackcurrant (Ribes nigrum) cultivars with and without pesticide treatment”. Food Chemistry 132 (2012): 1214-1220.
  64. Kim B., et al. “Blackcurrant anthocyanins stimulated cholesterol transport via post-transcriptional induction of LDL receptor in Caco-2 cells”. European Journal of Nutrition 57 (2018): 405-415.
  65. Kim B., et al. “Blueberry, blackberry, and blackcurrant differentially affect plasma lipids and pro-inflammatory markers in diet-induced obesity mice”. Nutrition Research and Practice 10 (2016): 494-500.
  66. Kong J-M., et al. “Analysis and biological activities of anthocyanins”. Phytochemistry 64 (2003): 923-933.
  67. Kontiokari T., et al. “Cranberry juice and bacterial colonization in childrenand#x2014;A placebo-controlled randomized trial”. Clinical Nutrition 24 (2005): 1065-1072.
  68. Laaksonen O., et al. “Impact of storage on sensory quality of blackcurrant juices prepared with or without enzymatic treatment at industrial scale”. European Food Research and Technology (2020): 10.
  69. Laaksonen OA., et al. “Chemical-Sensory Characteristics and Consumer Responses of Blackcurrant Juices Produced by Different Industrial Processes”. Food and Bioprocess Technology 7 (2014): 2877-2888.
  70. Laaksonen OA., et al. “Proanthocyanidins and Their Contribution to Sensory Attributes of Black Currant Juices”. Journal of Agricultural and Food Chemistry 63 (2015): 5373-5380.
  71. Lee SG., et al. “Berry anthocyanins suppress the expression and secretion of proinflammatory mediators in macrophages by inhibiting nuclear translocation of NF-kappa B independent of NRF2-mediated mechanism”. Journal of Nutritional Biochemistry 25 (2014): 404-411.
  72. Lee SG., et al. “Contribution of Anthocyanin Composition to Total Antioxidant Capacity of Berries”. Plant Foods for Human Nutrition 70 (2015): 427-432.
  73. Lee SG., et al. “Evaluation of pH differential and HPLC methods expressed as cyanidin-3-glucoside equivalent for measuring the total anthocyanin contents of berries”. Journal of Food Measurement and Characterization 10 (2016): 562-568.
  74. Lee Y and Lee JY. “Blackcurrant (Ribes nigrum) Extract Exerts an Anti-Inflammatory Action by Modulating Macrophage Phenotypes”. Nutrients 11 (2019): 11.
  75. Lee Y., et al. “Blackcurrant (Ribes nigrum) Prevents Obesity-Induced Nonalcoholic Steatohepatitis in Mice”. Obesity 27 (2019): 112-120.
  76. Leon-Gonzalez AJ., et al. “Delphinidin-3-O-glucoside and delphinidin-3-O-rutinoside mediate the redox-sensitive caspase 3-related pro-apoptotic effect of blackcurrant juice on leukaemia Jurkat cells”. Journal of Functional Foods 17 (2015): 847-856.
  77. Levy R., et al. “The Influence of Chemical Structure and the Presence of Ascorbic Acid on Anthocyanins Stability and Spectral Properties in Purified Model Systems”. Foods 8 (2019): 207.
  78. Li XR., et al. “An efficient homogenate-microwave-assisted extraction of flavonols and anthocyanins from blackcurrant marc: Optimization using combination of Plackett-Burman design and Box-Behnken design”. Industrial Crops and Products 94 (2016): 834-847.
  79. Liu Y., et al. “Proanthocyanidin synthesis in Theobroma cacao: genes encoding anthocyanidin synthase, anthocyanidin reductase, and leucoanthocyanidin reductase”. BMC Plant Biology 13 (2013): 202.
  80. Ljevar A., et al. “Phenolic Composition, Antioxidant Capacity and in vitro Cytotoxicity Assessment of Fruit Wines”. Food Technology and Biotechnology 54 (2016): 145-155.
  81. Manach C., et al. “Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies1,2,3”. The American Journal of Clinical Nutrition 81 (2005): 230S-242S.
  82. Marie-Claire Toufektsian., et al. “Chronic Dietary Intake of Plant-Derived Anthocyanins Protects the Rat Heart against Ischemia-Reperfusion Injury”. The Journal of Nutrition 138 (2008): 747-752.
  83. Matsumoto H., et al. “Ingested Delphinidin-3-rutinoside Is Primarily Excreted to Urine as the Intact Form and to Bile as the Methylated Form in Rats”. Journal of Agricultural and Food Chemistry 54 (2006): 578-582.
  84. Mattila PH., et al. “High variability in flavonoid contents and composition between different North-European currant (Ribes spp.) varieties”. Food Chemistry 204 (2016): 14-20.
  85. Mattioli R., et al. “Anthocyanins: A Comprehensive Review of Their Chemical Properties and Health Effects on Cardiovascular and Neurodegenerative Diseases”. Molecules 25 (2020): 3809.
  86. Matute A., et al. “Compared Phenolic Compound Contents of 22 Commercial Fruit and Vegetable Juices: Relationship to Ex-Vivo Vascular Reactivity and Potential In Vivo Projection”. Antioxidants 9 (2020): 18.
  87. Mazza G., et al. “Absorption of Anthocyanins from Blueberries and Serum Antioxidant Status in Human Subjects”. Journal of Agricultural and Food Chemistry 50 (2002): 7731-7737.
  88. McGhie TK and Walton MC. “The bioavailability and absorption of anthocyanins: Towards a better understanding”. Molecular Nutrition and Food Research 51 (2007): 702-713.
  89. Michalska A., et al. “Functional relationships between phytochemicals and drying conditions during the processing of blackcurrant pomace into powders”. Advanced Powder Technology 28 (2017): 1340-1348.
  90. Mofasser Hossain AKM., et al. “Cellular biological activity and regulation of gene expression of antioxidant dietary fibre fraction isolated from blackcurrant incorporated in the wholemeal cereals cookies”. Food Chemistry 312 (2020): 125829.
  91. Mofasser Hossain AKM., et al. “The Combined Effect of Blackcurrant Powder and Wholemeal Flours to Improve Health Promoting Properties of Cookies”. Plant Foods and Hum Nutrition 72 (2017): 280-287.
  92. Moskaug JØ., et al. “Dietary polyphenols identified as intracellular protein kinase A inhibitors”. European Journal of Nutrition 47 (2008): 460-469.
  93. Murphy CA., et al. “Effect of New Zealand Blackcurrant Extract on Repeated Cycling Time Trial Performance”. Sports 5 (2017): 6.
  94. Murphy CA., et al. “Effect of New Zealand Blackcurrant Extract on Repeated Cycling Time Trial Performance”. Sports 5 (2017): 25.
  95. Nanashima N., et al. “Anthocyanin-rich blackcurrant extract inhibits proliferation of the MCF10A healthy human breast epithelial cell line through induction of G0/G1 arrest and apoptosis”. Molecular Medicine Reports 16 (2017): 6134-6141.
  96. Nanashima N., et al. “Phytoestrogenic activity of blackcurrant (Ribes nigrum) anthocyanins is mediated through estrogen receptor alpha”. Molecular Nutrition and Food Research 59 (2015): 2419-2431.
  97. Neri-Numa IA., et al. “Natural prebiotic carbohydrates, carotenoids and flavonoids as ingredients in food systems”. Current Opinion in Food Science 33 (2020): 98-107.
  98. Nolan A., et al. “Short-term, but not acute, intake of New Zealand blackcurrant extract improves insulin sensitivity and free-living postprandial glucose excursions in individuals with overweight or obesity”. European Journal of Nutrition (2020): 10.
  99. Norberto S., et al. “Blueberry anthocyanins in health promotion: A metabolic overview”. Journal of Functional Foods 5 (2013): 1518-1528.
  100. Nour V., et al. “Anthocyanins profile, total phenolics and antioxidant activity of black currant ethanolic extracts as influenced by genotype and ethanol concentration”. Food and Function 141 (2013): 961-966.
  101. Nyanhanda T., et al. “Blackcurrant cultivar polyphenolic extracts suppress CCL26 secretion from alveolar epithelial cells”. Food and Function 5 (2014): 671-677.
  102. Okamoto T., et al. “Effects of blackcurrant extract on arterial functions in older adults: A randomized, double-blind, placebo-controlled, crossover trial”. Clinical and Experimental Hypertension (2020): 8.
  103. Okatan V. “Antioxidant properties and phenolic profile of the most widely appreciated cultivated berry species: A comparative study”. Folia Horticulturae 32 (2020): 79-85.
  104. Oktar S., et al. “The relationship between phthalates and obesity: Serum and urine concentrations of phthalates”. Minerva Endocrinologica 42 (2017): 46.
  105. Olejnik A., et al. “ROS-modulating anticancer effects of gastrointestinally digested Ribes nigrum L. fruit extract in human colon cancer cells”. Journal of Functional Foods 42 (2018): 224-236.
  106. Olejnik A., et al. “A Gastrointestinally Digested Ribes nigrum L. Fruit Extract Inhibits Inflammatory Response in a Co-culture Model of Intestinal Caco-2 Cells and RAW264.7 Macrophages”. Journal of Agricultural and Food Chemistry 64 (2016): 7710-7721.
  107. Overall J., et al. “Metabolic Effects of Berries with Structurally Diverse Anthocyanins”. International Journal of Molecular Sciences 18 (2017): 16.
  108. Ozkan G., et al. “A review of microencapsulation methods for food antioxidants: Principles, advantages, drawbacks and applications”. Food Chemistry 272 (2019): 494-506.
  109. Parada J and Aguilera JM. “Food Microstructure Affects the Bioavailability of Several Nutrients”. Journal of Food Science 72 (2007): R21-R32.
  110. Parkar SG., et al. “In vitro studies of modulation of pathogenic and probiotic bacterial proliferation and adhesion to intestinal cells by blackcurrant juices”. Journal of Functional Foods 8 (2014): 35-44.
  111. Paturi G., et al. “Effects of Blackcurrant and Dietary Fibers on Large Intestinal Health Biomarkers in Rats”. Plant Foods for Human Nutrition 73 (2018): 54-60.
  112. Piechowiak T and Balawejder M. “Impact of ozonation process on the antioxidant status in blackcurrant Ribes nigrum L. fruit”. Journal of Berry Research 9 (2019): 575-585.
  113. Potter JA., et al. “Effects of New Zealand blackcurrant extract on sport climbing performance”. European Journal of Applied Physiology 120 (2020): 67-75.
  114. Raudsepp P., et al. “Antibacterial and antioxidative properties of different parts of garden rhubarb, blackcurrant, chokeberry and blue honeysuckle”. Journal of the Science of Food and Agriculture 99 (2019): 2311-2320.
  115. Rechner AR., et al. “The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites”. Free Radical Biology and Medicine 36 (2002): 1229-1241.
  116. Reissner AM., et al. “Composition and physicochemical properties of dried berry pomace”. Journal of the Science of Food and Agriculture 99 (2019): 1284-1293.
  117. Rose PM., et al. “Application of Anthocyanins from Blackcurrant (Ribes nigrum L.) Fruit Waste as Renewable Hair Dyes”. Journal of Agricultural and Food Chemistry 66 (2018): 6790-6798.
  118. Sadowska A., et al. “Properties and microstructure of blackcurrant powders prepared using a new method of fluidized-bed jet milling and drying versus other drying methods”. CyTA- Food and Function 17 (2019): 439-446.
  119. Sakaki J., et al. “Blackcurrant Supplementation Improves Trabecular Bone Mass in Young but Not Aged Mice”. Nutrients 10 (2018): 12.
  120. Sandhu AK., et al. “Metabolic fate of strawberry polyphenols after chronic intake in healthy older adults”. Food and Function 9 (2018): 96-106.
  121. Schmidt C., et al. “Blackcurrant pomace from juice processing as partial flour substitute in savoury crackers: dough characteristics and product properties”. International Journal of Food Science and Technology 53 (2018): 237-245.
  122. Shaw OM., et al. “Blackcurrant anthocyanins modulate CCL11 secretion and suppress allergic airway inflammation”. Molecular Nutrition and Food Research 61 (2017): 7.
  123. Shukitt-Hale B., et al. “Dietary supplementation with fruit polyphenolics ameliorates age-related deficits in behavior and neuronal markers of inflammation and oxidative stress”. Age 27 (2005): 49-57.
  124. Slimestad R and Solheim H. “Anthocyanins from Black Currants (Ribes nigrum L.)”. Journal of Agricultural and Food Chemistry 50 (2002): 3228-3231.
  125. Smeriglio A., et al. “Proanthocyanidins and hydrolysable tannins: occurrence, dietary intake and pharmacological effects”. British Journal of Pharmacology 174 (2017): 1244-1262.
  126. Stanys V., et al. “Management of anthocyanin amount and composition in genus Ribes using interspecific hybridisation”. Scientia Horticulturae 247 (2019): 123-129.
  127. Strathearn KE., et al. “Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson's disease”. Brain Research 1555 (2014): 60-77.
  128. Strauss JA., et al. “New Zealand blackcurrant extract enhances fat oxidation during prolonged cycling in endurance-trained females”. European Journal of Applied Physiology 118 (2018): 1265-1272.
  129. Strugala P., et al. “Activity of Blackcurrant and Chokeberry Extracts and Two Major Cyanidin Glycosides Against Lipid Membrane Oxidation and Their Binding Proerties to Albumin”. Acta Poloniae Pharmaceutica 74 (2017): 679-687.
  130. Suganyadevi P., et al. “Characterization of anthocyanin from red sorghum (Sorghum bicolor) bran by liquid chromatography-electron spray ionization mass spectrometry analysis”. European Journal of Mass Spectrometry 27 (2021): 107-114.
  131. Tabart J., et al. “The potency of commercial blackcurrant juices to induce relaxation in porcine coronary artery rings is not correlated to their antioxidant capacity but to their anthocyanin content”. Nutrition 51-52 (2018): 53-59.
  132. Talavéra S., et al. “Anthocyanins are efficiently absorbed from the stomach in anesthetized rats”. The Journal of Nutrition 133 (2003): 4178-4182.
  133. Tani T., et al. “Delphinidin 3-rutinoside-rich blackcurrant extract ameliorates glucose tolerance by increasing the release of glucagon-like peptide-1 secretion”. Food Science and Nutrition 5 (2017): 929-933.
  134. Tian Y., et al. “Compositional Diversity among Blackcurrant (Ribes nigrum) Cultivars Originating from European Countries”. Journal of Agricultural and Food Chemistry 67 (2019): 5621-5633.
  135. Tomisawa T., et al. “Effects of Blackcurrant Anthocyanin on Endothelial Function and Peripheral Temperature in Young Smokers”. Molecules 24 (2019): 4295.
  136. Tomisawa T., et al. “Effects of Blackcurrant Anthocyanin on Endothelial Function and Peripheral Temperature in Young Smokers”. Molecules 24 (2019): 10.
  137. Torronen R., et al. “Postprandial glycaemic response to berry nectars containing inverted sucrose”. Journal of Nutritional Science 6 (2017): 7.
  138. Törrönen R., et al. “Postprandial glycaemic response to berry nectars containing inverted sucrose”. Journal of Nutritional Science 6 (2017): e4.
  139. Törrönen R., et al. “Fortification of blackcurrant juice with crowberry: Impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects”. Journal of Functional Foods 4 (2012): 746-756.
  140. Torronen R., et al. “Fortification of blackcurrant juice with crowberry: Impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects”. Journal of Functional Foods 4 (2012): 746-756.
  141. Trych U., et al. “The Bioaccessibility of Antioxidants in Black Currant Puree after High Hydrostatic Pressure Treatment”. Molecules 25 (2020): 15.
  142. Vanzo A., et al. “Uptake of grape anthocyanins into the rat kidney and the involvement of bilitranslocase”. Molecular Nutrition and Food Research 52 (2008): 1106-1116.
  143. Walton MC., et al. “Viscous Food Matrix Influences Absorption and Excretion but Not Metabolism of Blackcurrant Anthocyanins in Rats”. Journal of Food Science 74 (2009): H22-H29.
  144. Walton MC., et al. “The Flavonol Quercetin-3-Glucoside Inhibits Cyanidin-3-Glucoside Absorption in Vitro”. Journal of Agricultural and Food Chemistry 54 (2006): 4913-4920.
  145. Wang H., et al. “Oxygen Radical Absorbing Capacity of Anthocyanins”. Journal of Agricultural and Food Chemistry 45 (1997): 304-309.
  146. Watson AW., et al. “Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults”. Journal of Functional Foods 17 (2015): 524-539.
  147. Watson AW., et al. “The impact of blackcurrant juice on attention, mood and brain wave spectral activity in young healthy volunteers”. Nutritional Neuroscience 22 (2019): 596-606.
  148. Watson AW., et al. “The pharmacodynamic profile of "Blackadder" blackcurrant juice effects upon the monoamine axis in humans: A randomised controlled trial”. Nutritional Neuroscience 23 (2020): 516-525.
  149. Willems ME., et al. “Beneficial Effects of New Zealand Blackcurrant Extract on Maximal Sprint Speed during the Loughborough Intermittent Shuttle Test”. Sports 4 (2016): 42.
  150. Willems MET., et al. “Effect of New Zealand Blackcurrant Extract on Cycling Performance and Substrate Oxidation in Normobaric Hypoxia in Trained Cyclists”. Sports 7 (2019): 9.
  151. Willems MET., et al. “Beneficial effects on fasting insulin and postprandial responses through 7-day intake of New Zealand blackcurrant powder”. FFHD - Functional Foods in Health and Disease 7 (2017): 483-493.
  152. Xiong S., et al. “Stability and antioxidant activity of black currant anthocyanins in solution and encapsulated in glucan gel”. Journal of Agricultural and Food Chemistry 54 (2006): 6201.
  153. Xue J., et al. “Enhanced Stability of Red-Fleshed Apple Anthocyanins by Copigmentation and Encapsulation”. Journal of the Science of Food and Agriculture 99 (2018): 3381-3390.
  154. Yang W., et al. “Enzymatic acylation of blackcurrant (Ribes nigrum) anthocyanins and evaluation of lipophilic properties and antioxidant capacity of derivatives”. Food Chemistry 281 (2019): 189-196.
  155. Yang W., et al. “Effects of Latitude and Weather Conditions on Proanthocyanidins in Blackcurrant (Ribes nigrum) of Finnish Commercial Cultivars”. Journal of Agricultural and Food Chemistry 67 (2019): 14038-14047.
  156. Zhang JT., et al. “Chemical compositions and alpha-glucosidase inhibitory effects of anthocyanidins from blueberry, blackcurrant and blue honeysuckle fruits”. Food Chemistry 299 (2019): 11.
  157. Zheng X., et al. “Anthocyanin-Rich Blackcurrant Extract Attenuates Ovariectomy-Induced Bone Loss in Mice”. Journal of Medicinal Food 19 (2016): 390-397.
  158. Ziberna L., et al. “The endothelial plasma membrane transporter bilitranslocase mediates rat aortic vasodilation induced by anthocyanins”. Nutrition, Metabolism, and Cardiovascular Diseases 23 (2013): 68-74.

Citation

Citation: Xin Shao, Gang Wu., et al. “Bioactivity, Bioavailability and Bioaccessibility of Blackcurrant Anthocyanins: An Updated Comprehensive Review". Acta Scientific Nutritional Health 6.3 (2022): 10-34.

Copyright

Copyright: © 2022 Xin Shao, Gang Wu., et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.316

Indexed In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is November 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US