Nutritional Genomics: Genes and Polymorphisms in Energy Metabolism: An Overview
Dra Thaís Verdi Clinical, Orthomolecular and Sports Nutritionist, Nutritionist in São Paulo, Brazil
*Corresponding Author: JThais Verdi, Dra Thaís Verdi Clinical, Orthomolecular and Sports Nutritionist, Nutritionist in São Paulo, Brazil.
November 30, 2021; Published: January 31, 2022
Recent studies have demonstrated the effects of nutrients on gene expression and their influence on skeletal muscle metabolism. Macronutrients play important roles, which through dietary signals control the metabolic programming of cells to maintain cell homeostasis, influencing specific gene expression. The effect of nutrients and their relationship to genes. In this review, we discuss advances in genetic studies of DNA polymorphisms and their association with energy metabolism. Various genes (AMPD1 C34T rs17602729, PPAR-⍶ (PPARA) rs8192678, PPAR-D (PPARD) rs2016520, PPAR-G (PPARG) rs 1807282, PGC 1 a (PPARGC1A) rs8192678, PPP3RUDD1) 1807282, PPAR8GC 1a, PPP3RUDD1 (PPARD) UCP006 UCP006 UCP006 UCP006 UCP006 UCP006 PPARG (PPARG) 1807282, PGC 1a (PPARGC1A) rs8192678; rs33 (PPARGC1A) GC1A, rs1937 and CLOCK/BMAL1 have been implicated in various aspects of skeletal muscle energy. Future research is guaranteed to explore multigenetic traits to provide a deeper molecular understanding, with greater genetic predisposition and metabolically flexible tissue, skeletal muscle largely contributes to the metabolic adaptation of the entire body.
Keywords: Genetic; Athletes; Sports Performance; Nutrients; Macronutrients; Exercise; Metabolism
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