Stacey J Bell¹ and Lindsey R Ormond²*

¹Nutritional Consultant, Boston, MA
²Director of Nutrition & Research, Milk Specialties Global, Eden Prairie, MN

*Corresponding Author: Lindsey R Ormond, Director of Nutrition & Research, Milk Specialties Global, Eden Prairie, MN

Received: December 13, 2021; Published: January 27, 2022

Abstract

After nearly two years of living with the COVID-19 pandemic, much has been learned. Today we know that the virus that causes COVID-19 is transmitted in the air, treatments have improved, and prevention of contracting it is possible through vaccination. This opens an opportunity for natural ingredients and bovine lactoferrin is considered to be one of the best options for treating and preventing COVID-19. Lactoferrin has been studied extensively before the identification of severe acute respiratory syndrome coronavirus (SARS-CoV-2), which causes COVID-19. It was found to be an anti-viral agent against other viruses, and now new research has shown it to be equally effective against the virus that causes COVID-19. In addition, lactoferrin has the potential to boost the body’s natural immune function without over-reacting. Clinical studies in COVID-19 patients, who took oral bovine lactoferrin, improved faster and tested negative for SARS-CoV-2 virus sooner compared to those who were not supplemented. Besides helping treat COVID-19 patients, lactoferrin holds promise for prevention against getting it. In one clinical trial, healthy subjects, who received supplemental lactoferrin, did not develop COVID-19 despite living with family members who had it. From the current body of evidence, it is possible to determine the right amount of lactoferrin to use if you contract COVID-19 and what you need to prevent it. For treatment, use of 500 mg to 1,000 mg daily of lactoferrin is recommended until symptoms associated with COVID-19 have improved or have gone away completely. For prevention, taking 250 mg to 500 mg daily is recommended. Lactoferrin is a well-tested, safe, and natural compound with the potential to help many during the COVID-19 pandemic.

Keywords: Lactoferrin; Dietary Supplements; Novel Coronavirus; Covid-19; Sars-Cov-2; Prevent COVID-19; Treat COVID-19

References

1. “Therapeutic Management of Hospitalized Adults With COVID-19”. Centers for Disease Control and Prevention. (2021).
2. Mirabelli C., et al. “Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19”. Proceedings of the National Academy of Sciences of the United States of America 36 (2021): e2105815118.
3. Slomski A. “Trials Test Mushrooms and Herbs as Anti-COVID-19 Agents”. JAMA 20 (2021): 1997-1999.
4. AlKhazindar M and Elnagdy SM. “Can lactoferrin boost human immunity against COVID-19?” Pathogens and Global Health 114 (2020): 234-235.
5. Mrityunjaya M., et al. “Immune-Boosting, Antioxidant and Anti-inflammatory Food Supplements Targeting Pathogenesis of COVID-19”. Frontiers in Immunology 11 (2020): 570122.
6. Serrano JM., et al. “Liposomal Lactoferrin as Potential Preventative and Cure for COVID-19”. International Journal of Health Sciences and Research1 (2020): 8-15.
7. Salaris C., et al. “Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro”. Nutrients2 (2021): 328.
8. “Symptoms of COVID-19”. Centers for Disease Control and Prevention (2021).
9. Wang Y., et al. “Lactoferrin for the treatment of COVID-19 (Review)”. Experimental and Therapeutic Medicine 6 (2020): 272.
10. Symptoms of COVID-19 (2021).
11. Chang R., et al. “Lactoferrin as potential preventative and adjunct treatment for COVID-19”. International Journal of Antimicrobial Agents 3 (2020).
12. Hu Y., et al. “The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor”. Emerging Microbes and Infections 10 (2021): 317-330.
13. Campione E., et al. “Lactoferrin as potential supplementary nutraceutical agent in COVID-19 patients: in vitro and in vivo preliminary evidence”. bioRxiv (2020).
14. Kell DB., et al. “The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria”. Frontiers in Immunology 11 (2020): 1221.
15. Zimecki M., et al. “The potential for Lactoferrin to reduce SARS-CoV-2 induced cytokine storm”. International Immunopharmacology 95 (2021): 107571.
16. Habib HM., et al. “The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators”. Biomedicine and Pharmacotherapy 136 (2021): 111228.
17. Algahtani FD., et al. “The Prospect of Lactoferrin Use as Adjunctive Agent in Management of SARS-CoV-2 Patients: A Randomized Pilot Study”. Medicina (Kaunas)8 (2021): 842.
18. Kilic E., et al. “Formulation for Oral Delivery of Lactoferrin Based on Bovine Serum Albumin and Tannic Acid Multilayer Microcapsules”. Scientific Report 7 (2017): 44159 (2017).
19. Superti F. “Lactoferrin from Bovine Milk: A Protective Companion for Life”. Nutrients 9 (2020): 2562.
20. Razak A and Hussain A. “Lactoferrin supplementation to prevent late-onset sepsis in preterm infants: a meta-analysis”. American Journal of Perinatology 3 (2019): 283-290.
21. Ishikado A., et al. “Liposomalization of lactoferrin enhanced it's anti-inflammatory effects via oral administration”. Biological and Pharmaceutical Bulletin 9 (2005): 1717-1721.
22. Ishikado A., et al. “Liposomal lactoferrin induced significant increase of the interferon-alpha (IFN-alpha) producibility in healthy volunteers”. Biofactors1-4 (2004): 69-72.
23. Holford P., et al. “Vitamin C-An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19”. Nutrients12 (2020): 3760.
24. Pal A., et al. “Zinc and COVID-19: Basis of Current Clinical Trials”. Biological Trace Element Research 8 (2021): 2882-2892.
25. Vitetta L., et al. “The clinical efficacy of a bovine lactoferrin/whey protein Ig-rich fraction (Lf/IgF) for the common cold: a double-blind randomized study”. Complementary Therapies in Medicine 3 (2003): 164-171.

Citation

Citation: Stacey J Bell and Lindsey R Ormond. “Lactoferrin for Treating and Preventing Covid-19: A Review". Acta Scientific Nutritional Health 6.2 (2022): 61-72.

Copyright

Copyright: © 2022 Stacey J Bell and Lindsey R Ormond. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.