Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Review Article Volume 5 Issue 12

Prevalence of Small Intestinal Bacterial Overgrowth in People with Gastrointestinal Signs and Symptoms Using Glucose Breath Test

Sheeza Imtiaz1,2*, Sanaullah Iqbal2, Imtiaz Rabbani3 and M Asif Ali2

1Department of Health Sciences, University of South Asia, Raiwind Road, Lahore, Pakistan
2Department of Food Science and Human Nutrition, University of Veterinary and Animal Sciences, Lahore, Pakistan
3Department of Physiology, University of Veterinary and Animal Sciences, Lahore, Pakistan

*Corresponding Author: Sheeza Imtiaz, Lecturer Food and Nutrition, Department of Health Sciences, University of South Asia, Raiwind Road, Lahore, Pakistan.

Received: September 03, 2021; Published: November 30, 2021


Small intestinal bacterial overgrowth (SIBO) is a condition characterized by high bacterial population in small intestine. Its overall worldwide prevalence is unknown due to under diagnosis and unspecific symptoms. In clinical setup, diagnosis of SIBO is still a big challenge. Aspiration and breath tests are two possible diagnostic tests. The study objective was to find prevalence of SIBO in individuals using Glucose H2 and CH4 breath tests and to develop association of SIBO with age, gender, BMI, food and exercise. Total 385 individuals participated in study. Initial screening was done using symptomatic questionnaire, filled by respondents in an interview style to find out suspected individuals. Total sum of each symptom was calculated. Individuals with total score of ≥5 were considered suspected for SIBO and further proceeded for confirmation through Glucose Breath Test (GBT) using 50g glucose in 200 mL water. Individuals having at least 12 ppm increase in H2 and / or CH4 over the lowest preceding value or the basal reading within test period, were considered as positive for SIBO. Chi-square test was applied to find correlation between various factors. P value < 0.05 was considered as significant. On the basis of screening, 14.02% individuals were found suspected to have SIBO on the basis of positive gastro-intestinal signs and symptoms. In overall tested population, 4.42% individuals were observed as SIBO positive, 9.61% were false positive and 85.97% were negative for SIBO. Prevalence was high among individuals consumed starchy food (70.6%) and did not performed exercise (65%). There is no association of SIBO with age, gender and BMI. It can be concluded that SIBO is present among individuals with gastro-intestinal signs and symptoms. Testing SIBO with both H2 and CH4 gave better possible results as compared to individual gas testing.

Keywords:Small Intestinal Bacterial Overgrowth; Glucose Breath Test; H2 Breath Test; CH4 Breath Test; Gastro-intestinal Sign and Symptoms


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Citation: Sheeza Imtiaz., et al. “Prevalence of Small Intestinal Bacterial Overgrowth in People with Gastrointestinal Signs and Symptoms Using Glucose Breath Test".Acta Scientific Nutritional Health 5.12 (2021): 127-137.


Copyright: © 2021 Sheeza Imtiaz., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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