Abstract

Flavonoids pigments, one of more numerous groups widely distributed of natural constituents, sometimes known as antoxantins, frequently appear in chemical literature, especially in the last 50 years, and they are characterized by their antioxidant activity, free radical scavenging capacity, coronary heart disease prevention, hepatoprotective, anti-inflammatory, and anticancer activities, while some flavonoids exhibit potential antiviral activities. Gossypitrin (G7G) the main chemical compound present in the petals of the flowers of Talipariti elatum (Sw.) that grow in Cuba was tested to determine its biological activities. This chemical compound is a flavonoid glycoside which is a gossypetin derivative with a sugar moiety attached in C7. flavonoids [12]. This review deals with the structural aspects of G7G and their protective roles against many human diseases.

Keywords:Flavonoids; Talipariti; Gossypitrin; Human Health; COVID-19

References

1. M F Mahomoodally., et al. “Antimicrobial activities and phytochemical profiles of endemic medicinal plants of Mauritius”. Pharmaceutical Biology3 (2005): 237-242.
2. A K Pandey. “Anti-staphylococcal activity of a pan-tropical aggressive and obnoxious weed Parihenium histerophorus: an in vitro study”. National Academy Science Letters11-12 (2007): 383-386.
3. S Kumar., et al. “Calotropis procera root extract has capability to combat free radical mediated damage”. ISRN Pharmacology (2013): 8.
4. N C Cook and S Samman. “Review: flavonoids-chemistry, metabolism, cardioprotective effects and dietary sources”. Journal of Nutritional Biochemistry2 (1996): 66-76.
5. R Koes., et al. “Flavonoids: a colorful model for the regulation and evolution of biochemical pathways”. Trends in Plant Sciences5 (2005): 236-242.
6. L H Yao., et al. “Flavonoids in food and their health benefits”. Plant Foods for Human Nutrition3 (2004): 113-122.
7. Rao P S and T R Seshadri. “Pigments of cotton flowers -Part VIII. Constitution of Herbacitrin and Quercimeritrin”. Proceedings of the Indian Academy of Sciences-Section A4 (1939): 365-369.
8. Saleh N A M., et al. “Flavonoids of Equisetum species”. Phytochemistry3 (1972): 1095-1099.
9. Amakura Y., et al. “Characterization of phenolic constituents from Ephedra herb extract”. Molecules5 (2013): 5326-5334.
10. Schliemann W., et al. “Flavonols and an indole alkaloid skeleton bearing identical acylated glycosidic groups from yellow petals of Papaver nudicaule”. Phytochemistry2 (2006): 191-201.
11. Braunberger C., et al. “LC-NMR, NMR, and LC-MS Identification and LC-DAD Quantification of Flavonoids and Ellagic Acid Derivatives in Drosera peltata”. Journal of Chromatography B 932 (2013): 111-116.
12. Rao PS and Seshradri TR. “Isolation of Hibiscitrin from the flowers of Hibiscus sabdariffa. Constitution of Hibescetin”. Proceedings Mathematical Sciences3 (1942): 148-153.
13. Rao RP and Seshadri TR. “Pigments of flowers of Hibiscus sabdariffa, isolation of sabdaretin, a new hydroxyflavone”. Proceedings of the Indian Academy of Sciences15 (1942): 323-327.
14. Subramanian SS and Nair AGR. “Flavonoids of four Malvaceous plants”. Phytochemistry 4 (1972): 15181519.
15. Nair AGR., et al. “Glycosides from the flowers of Hibiscus tiliaceus”. Journal Scientific Industrial Research (India) (1961): 20B:553.
16. Márquez Hernández I., et al. “Estudio fitoquímico de la especie Hibiscus elatus S.w”. Revista Cubana de Farmacia – Medigraphic 2 (1999): 127-131.
17. Yaque JG., et al. “Isolation and Characterization of Flavonols by HPLC-UV-ESI-MS/MS from Talipariti elatum S.w”. American Journal of Plant Sciences 7 (2016): 1198-1204.
18. K R Narayana., et al. “Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential”. Indian Journal of Pharmacology1 (2001): 2-16.
19. E Middleton. “The flavonoids”. Trends in Pharmacological Sciences 5 (1984): 335-338.
20. C A Rice-Evans., et al. “Structure- antioxidant activity relationships of flavonoids and phenolic acids”. Free Radical Biology and Medicine7 (1996): 933-956.
21. González J., et al. “Pharmacognostical and phytochemical studies of flowers from Talipariti elatum S.w”. International Journal of Engineering Research and Science (IJOER)6 (2016): 69-74.
22. Erdogdu Y., et al. “Structural conformations and vibrational spectral study of chloroflavone with density functional theoretical simulations”. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2 (2010): 130-136.
23. Li XH., et al. “Molecular structure and vibrational spectra of three substituted 4-thioflavones by density functional theory and ab initio Hartree-Fock calculations”. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy1 (2011): 528-536.
24. Tsimogiannis D., et al. “Characterization of Flavonoid Subgroups and Hydroxy Substitution by HPLC-MS/MS”. Molecules 12 (2007): 593-606.
25. Braunberger C., et al. “LC-NMR, NMR, and LC-MS Identification and LC-DAD Quantification of Flavonoids and Ellagic Acid Derivatives in Drosera peltate”. Journal of Chromatography B 932 (2013): 111-116.
26. Cuéllar A and González J. “Obtención del glucósido flavonoide gossypitrina de los pétalos de las flores de Talipariti elatum s.w. y evaluación de su posible efecto antioxidante”. Revista Colombiana de Ciencia Animal. Número 2, Volumen 2, semestre julio-diciembre del (2010): 338-348.
27. EH Kelly., et al. “Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships”. Journal of Nutritional Biochemistry10 (2002): 572-584.
28. González J., et al. “Antioxidant Activity of gossypitrin isolated from the petals of Talipariti elatum (Sw.) Fryxell (Malvaceae) in Cuba”. International Journal of Engineering Research and General Science (IJOER)10 (2017): 17-22.
29. Rice-Evans CA and Miller NJ. “Antioxidants activities of flavonoids as bioactive components of food”. Biochemical Society Transactions 24 (1996): 790-795.
30. Halliwell B and Gutteridge JMC. Free Radicals in Biology and Medicine, Oxford University Press, Oxford, UK (1998).
31. Mishra A., et al. “Scientific validation of the medicinal efficacy of Tinospora cordifolia”. The Scientific World Journal 2013 (2013).
32. González J., et al. “Iron Chelating Activity of Gossypitrin Isolated from the Petals of Talipariti Elatum Sw. (Fryxell) Malvaceae”. Journal of Agricultural Studies (JAS) 2 (2017).
33. A Van., et al. “Structural aspects of antioxidant activity of flavonoids”. Free Radical Biology and Medicine3 (1996): 331-342.
34. González J., et al. “Antibacterial and antifungal activities of Gossypitrin from Talipariti elatum Sw. (Fryxell)”. International Journal of Current Microbiology and Applied Sciences 11 (2016): 860-866.
35. Zhao M., et al. “Oxidative stress in hypoxic-ischemic encephalopathy: molecular mechanisms and therapeutic strategies”. International Journal of Molecular Sciences 17 (2016): E2078.
36. Ren Y., et al. “Edaravone's free radical scavenging mechanisms of neuroprotection against cerebral ischemia: review of the literature”. International Journal of Neuroscience 125 (2015): 555-565.
37. Bécquer-Viart MA., et al. “Antioxidant and neuroprotective effects of gossypitrin, a flavonoid from Talipariti elatum, against chemical hypoxia-induced PC12 cell death”. Journal of Pharmacy and Pharmacognosy Research 2 (2018): 72-80.
38. Tahir Ul Qamar M., et al. “Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants”. Journal of Pharmaceutical Analysis 4 (2020): 313-319.
39. Wang G and Zhu W. “Molecular docking for drug discovery and development: a widely used approach but far from perfect”. Future Medicinal Chemistry 14 (2016): 1707-1710.
40. Lipinski CA., et al. “Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings”. Advanced Drug Delivery Reviews 1-3 (2001): 3-26.
41. Giguet Valard AG., et al. “Gossypetin Derivatives are also Putative Inhibitors of SARS-COV 2: Results of a Computational Study”. Journal of Biomedical Research and Environmental Sciences 6 (2020): 201-212.

Citation

Citation: José González., et al. “Biological Activities of Gossypitrin: A review".Acta Scientific Nutritional Health 5.11 (2021): 77-84.

Copyright

Copyright: © 2021 José González., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.