Eymundsdottir H1*, Chang M1, Geirsdottir OG2, Jonsson PV1,3,4, Gudnason V3,5, Launer L6 and Ramel A2
1The Icelandic Gerontological Research Center, the National University Hospital of Iceland, Reykjavik, Iceland
2Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland
3Faculty of Medicine, University of Iceland, Iceland
4Department of Geriatrics, the National University Hospital of Iceland, Reykjavik, Iceland
5Icelandic Heart Association, Kopavogur, Iceland
6Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
*Corresponding Author: : Eymundsdottir H, The Icelandic Gerontological Research Center, the National University Hospital of Iceland, Reykjavik, Iceland.
Received: October 05, 2021; Published: October 21, 2021
Introduction: We aim to investigate the longitudinal associations between level of physical activity (PA) and the risk of mild cognitive impairment (MCI) and dementia among type 2 diabetes (T2D) and pre-diabetes (PD) participants who are cognitively normal at study entry.
Methods: We used data from the Age-Gene/Environment-Susceptibility-Reykjavik-Study (65-96 years). From the original sample, 3001 participants with a complete evaluation of T2D, MCI and dementia were included in this analysis.
Results: During follow-up (5.2 years), 8.5% (n = 256) developed MCI and 3.7% (n = 111) developed dementia. T2D participants had an increased risk for MCI (OR = 1.632, P = 0.021) and both PD and T2D individuals had increased risk for dementia (OR = 1.947, P = 0.003 and OR=2.101, P = 0.026). PA was associated with lower dementia risk in normal participants only (OR = 0.611, P = 0.019).
Discussion: Older adults with PD/T2D had low level of PA and higher risk of declining cognitive function.
Keywords: Type 2 Diabetes; Mild Cognitive Impairment; Dementia; Physical Activity; Glucose Regulations
Citation: Eymundsdottir H., et al. “Type 2 Diabetes, Physical Activity and Risk of Mild Cognitive Impairment and Dementia in Community Dwelling Old Adults".Acta Scientific Nutritional Health 5.11 (2021): 59-66.
Copyright: © 2021 Eymundsdottir H., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.