Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Research Article Volume 5 Issue 9

Elucidating Hyperglycemic and Hyperlipidemic Potential of Basil Seed Gum Aqueous Extract Powder in Diabetic Rat Model

Mavra Javed1*, Waqas Ahmed1, Abdul Momin Rizwan Ahmad2 and Samar Rashid3

1Department of Food Science and Human Nutrition, University of Veterinary and Animal Sciences, Lahore, Pakistan
2Department of Human Nutrition and Dietetics, National University of Medical Sciences (NUMS), Rawalpindi, Pakistan
3Department of Food and Nutrition, Minhaj University, Lahore, Pakistan

*Corresponding Author: Mavra Javed, Department of Food Science and Human Nutrition, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Received: July 23, 2021; Published: August 12, 2021


Lifestyle diseases evolved during 20th century to promote epidemiological landscape with increasing industrial growth and climate change. Diabetes mellitus, obesity, hypertension, heart diseases, stroke, pulmonary diseases, and mental diseases along with alcohol abuse and smoking increase the risk of mortality and morbidity in population. So, the current study was conducted to evaluate aqueous extract powder of Ocimum basilicum potential against streptozotocin induced hyperglycemia with its potential to ameliorate biochemical parameters associated with liver and kidney functionality and body weight in albino rats. Four groups of albino rats were selected having six rats in each group (control group, diabetic group, 0.5% and 1% treatment group. Biochemical parameters which were evaluated were AST, ALP, ALT, total bilirubin, total protein, albumin, globulin, creatinine, and urea along with estimation of total cholesterol, triglycerides, HDL, and LDL. Aqueous extract powder significantly reduced blood glucose levels at both doses. Body weight was also improved significantly. Biochemical parameters for liver and kidney tests along with lipid profile was also improved showed ameliorated effect of extract powder. Mainly 1% basil seed gum showed prominent improvement in blood glucose parameters along with other biochemical parameters. This study concludes that both levels of BSG powder have notable possible effect to reduce hyperglycemia and hyperlipidemia associated with diabetes. Therefor it may be helpful in diabetes management.

Keywords: Hypoglycemic Potential; Basil Seeds Gum; Albino Rats; Hyperlipidemia; Aqueous Extract


  1. Khan Saifur R., et al. "Ai-Integration and Plant-Based Traditional Medicine for Drug Discovery”. Drug Discovery Today (2021).
  2. Kumar Narinder and Mohd Ashaq. "Safety and Toxicity of Botanical Medicines: A Critical Appraisal”. International Journal of All Research Education and Scientific Methods7 (2021).
  3. Arentzen Thomas., et al. "In the Beginning, Trees”. Byzantine Tree Life. Springer (2021): 65-106.
  4. Naji-Tabasi Sara and Seyed Mohammad Ali. "Functional Properties and Applications of Basil Seed Gum: An Overview”. Food Hydrocolloids 73 (2017): 313-325.
  5. Saeedi Pouya., et al. "Global and Regional Diabetes Prevalence Estimates for 2019 and Projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas”. Diabetes Research and Clinical Practice 157 (2019): 107843.
  6. Basit Abdul., et al. "Prevalence of Diabetes, Pre-Diabetes and Associated Risk Factors: Second National Diabetes Survey of Pakistan (Ndsp), 2016–2017”. BMJ Open8 (2018): e020961.
  7. Jakovljevic Mihajlo., et al. "Comparative Financing Analysis and Political Economy of Noncommunicable Diseases”. Journal of Medical Economics8 (2019): 722-727.
  8. Peng Jieru., et al. "Association between Dyslipidemia and Risk of Type 2 Diabetes Mellitus in Middle-Aged and Older Chinese Adults: A Secondary Analysis of a Nationwide Cohort”. BMJ Open5 (2021): e042821.
  9. Narindrarangkura Ploypun., et al. "Prevalence of Dyslipidemia Associated with Complications in Diabetic Patients: A Nationwide Study in Thailand”. Lipids in Health and Disease1 (2019): 90.
  10. Shahwan Moyad Jamal., et al. "Prevalence of Dyslipidemia and Factors Affecting Lipid Profile in Patients with Type 2 Diabetes”. Diabetes and Metabolic Syndrome: Clinical Research and Reviews4 (2019): 2387-2392.
  11. Imam H., et al. "Extraction of an Antidiabetic Polysaccharide from Seeds of Ocimum Basilicum and Determination of the Monosaccharide Composition by Precolumn High-Efficiency Capillary Electrophoresis A”. Chemistry of Natural Compounds4 (2012): 653-654.
  12. Razavi, Seyed MA., et al. "Optimisation Study of Gum Extraction from Basil Seeds (Ocimum Basilicum L.)”. International journal of food Science and Technology9 (2009): 1755-1762.
  13. Sajadimajd Soraya., et al. "Plant-Derived Supplementary Carbohydrates, Polysaccharides and Oligosaccharides in Management of Diabetes Mellitus: A Comprehensive Review”. Food Reviews International6 (2019): 563-586.
  14. Qureshi Jabbar Ahmed., et al. "Anti Hyperglycemic and Anti Dyslipidemic Effects of Flax Seeds (Linum Usitatissimum) Extract in Diabetic Rats Model” (2019).
  15. Chaudhary Sachin., et al. "In-Vivo Study for Anti-Hyperglycemic Potential of Aqueous Extract of Basil Seeds (Ocimum Basilicum Linn) and Its Influence on Biochemical Parameters, Serum Electrolytes and Haematological Indices”. Biomed Pharmacotherapy 84 (2016): 2008-2013.
  16. Lee Yong-ho., et al. "Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis”. Diabetes and Metabolism1 (2019): 31-45.
  17. Khan Reenam S., et al. "Modulation of Insulin Resistance in Nonalcoholic Fatty Liver Disease”. Hepatology 2 (2019): 711-724.
  18. Winocour PH. "Diabetes and Chronic Kidney Disease: An Increasingly Common Multi‐Morbid Disease in Need of a Paradigm Shift in Care”. Diabetic Medicine: A Journal of the British Diabetic Association3 (2018): 300-305.
  19. Dhama Kuldeep., et al. "A Comprehensive Review on Chemical Profile and Pharmacological Activities of Ocimum Basilicum”. Food Reviews International (2021): 1-29.
  20. Johannesen Camilla Ditlev Lindhardt., et al. "Apolipoprotein B and Non-Hdl Cholesterol Better Reflect Residual Risk Than Ldl Cholesterol in Statin-Treated Patients”. Journal of the American College of Cardiology11 (2021): 1439-1450.
  21. Harnafi Hicham., et al. "Hypolipemic Activity of Polyphenol-Rich Extracts from Ocimum Basilicum in Triton Wr-1339-Induced Hyperlipidemic Mice”. Phytotherapy Research1 (2008): 205-212.
  22. Sobczak Amélie IS., et al. "Lipidomic Profiling of Plasma Free Fatty Acids in Type-1 Diabetes Highlights Specific Changes in Lipid Metabolism”. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids1 (2021): 158823.
  23. Chen Lifang., et al. "The Association of Parameters of Body Composition and Laboratory Markers with the Severity of Hypertriglyceridemia-Induced Pancreatitis”. Lipids in Health and Disease1 (2021): 1-11.


Citation: Mavra Javed., et al. “Elucidating Hyperglycemic and Hyperlipidemic Potential of Basil Seed Gum Aqueous Extract Powder in Diabetic Rat Model". Acta Scientific Nutritional Health 5.9 (2021): 40-46.


Copyright: © 2021 Mavra Javed., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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