Elucidating Hyperglycemic and Hyperlipidemic Potential of Basil Seed Gum Aqueous
Extract Powder in Diabetic Rat Model
Mavra Javed1*, Waqas Ahmed1, Abdul Momin Rizwan Ahmad2 and
1Department of Food Science and Human Nutrition, University of Veterinary and Animal Sciences, Lahore, Pakistan
2Department of Human Nutrition and Dietetics, National University of Medical Sciences (NUMS), Rawalpindi, Pakistan
3Department of Food and Nutrition, Minhaj University, Lahore, Pakistan
*Corresponding Author: Mavra Javed, Department of Food Science and Human Nutrition, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Received: July 23, 2021; Published: August 12, 2021
Lifestyle diseases evolved during 20th century to promote epidemiological landscape with increasing industrial growth and climate change. Diabetes mellitus, obesity, hypertension, heart diseases, stroke, pulmonary diseases, and mental diseases along with alcohol abuse and smoking increase the risk of mortality and morbidity in population. So, the current study was conducted to evaluate aqueous extract powder of Ocimum basilicum potential against streptozotocin induced hyperglycemia with its potential to ameliorate biochemical parameters associated with liver and kidney functionality and body weight in albino rats. Four groups of albino rats were selected having six rats in each group (control group, diabetic group, 0.5% and 1% treatment group. Biochemical parameters which were evaluated were AST, ALP, ALT, total bilirubin, total protein, albumin, globulin, creatinine, and urea along with estimation of total cholesterol, triglycerides, HDL, and LDL. Aqueous extract powder significantly reduced blood glucose levels at both doses. Body weight was also improved significantly. Biochemical parameters for liver and kidney tests along with lipid profile was also improved showed ameliorated effect of extract powder. Mainly 1% basil seed gum showed prominent improvement in blood glucose parameters along with other biochemical parameters. This study concludes that both levels of BSG powder have notable possible effect to reduce hyperglycemia and hyperlipidemia associated with diabetes. Therefor it may be helpful in diabetes management.
Keywords: Hypoglycemic Potential; Basil Seeds Gum; Albino Rats; Hyperlipidemia; Aqueous Extract
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