Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Research Article Volume 5 Issue 7

Vitamin D Deficiency can Accelerate Heart Failure: A Systematic Review and Meta-analysis

Irem Akin1 and Nuray Yazihan1,2*

1Metabolism and Clinical Nutrition Department, Ankara University, Institute of Health Sciences Interdisciplinary Food, Ankara, Turkey
2Department of Pathophysiology, Ankara University, Faculty of Medicine, Ankara, Turkey

*Corresponding Author: Nuray Yazihan, Professor, Internal Medicine, Department of Pathophysiology, Ankara University, Faculty of Medicine, Ankara, Turkey.

Received: April 07, 2021; Published: June 24, 2021


Background: Cardiovascular diseases (CVDs) are one of the most important causes of mortality all around the world. Studies have been shown that vitamin D is closely related CVDs, including heart failure (HF). We aim to assess the serum vitamin D levels in patients with HF in this meta-analysis.

Methods: A systematic research was performed in Pubmed, Web of Science, and Scopus databases for following keywords; "vitamin D level" OR "vitamin D status" AND "heart failure" until September 2020. Each step of the meta-analysis is appropriate to the PRISMA guideline. Totally, 2968 publications were screened and 16 articles were found to have suitable data. Analysis was done with RevMan 5.3. software. We also used GraphPad Prism 6 software for the correlation analysis and figures.

Results: Our pooled data showed that patients with HF had significantly lower levels of serum vitamin D compared to controls (REM p < 0.00001 mean difference: -8.20 [-10.46, -5.95]). There was also significant correlation between serum vitamin D level and left ventricular ejection fraction (LVEF) (p: 0.0134, r: 0.4785) (n = 26).

Conclusion: In this meta-analysis, it has been indicated that HF patients have lower serum vitamin D levels compared to controls. As seen in our study, vitamin D might be an important risk factor for HF, and vitamin D deficiency (VDD) may lead increased mortality caused by HF. Further researches are needed to elucidate which mechanisms play a role in the association between HF and vitamin D.

Keywords: Vitamin D; Vitamin D Deficiency; Cardiovascular Diseases; Heart Failure; Meta-analysis


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Citation: Irem Akin and Nuray Yazihan. “Vitamin D Deficiency can Accelerate Heart Failure: A Systematic Review and Meta-analysis". Acta Scientific Nutritional Health 5.7 (2021): 64-71.


Copyright: © 2021 Irem Akin and Nuray Yazihan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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