Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Review Article Volume 5 Issue 6

Role of HIF 1 α in Covid-19 Disease

Tulsi Patil1*, Chirag Patel2, Arun Soni3 and Sanjeev Acharya3

1Research Scholar, SSR College of Pharmacy, UT of Dadra and Nagar Haveli, India
2L. M. College of Pharmacy, Ahmedabad, India
3SSR College of Pharmacy, UT of Dadra and Nagar Haveli, India

*Corresponding Author: Tulsi Patil, Research Scholar, SSR College of Pharmacy, UT of Dadra and Nagar Haveli, India.

Received: April 28, 2021; Published: May 24, 2021


This review article aims to point out the many roles of HIF-1α in COVID-19 diseases. World health organization named the newly emerged virus SARS-CoV-2 or 2019-nCoV or covid-19. At beginning of coronavirus symptoms of pneumonia were appeared in December 2019 near Wuhan city of China. The Coronavirus Disease 2019 outbreak spread rapidly worldwide and is associated with the high death rate in humans. However, there are currently fewer safe and effective drugs available for targeting SARS-CoV-2. So, there is an emergency for the invention of effective prevention and treatment options for the SARS-CoV-2 outbreak. SARS-CoV-2 recognizes the human ACE2 more strongly than SARS-CoV. SARS-CoV-2 spike supermolecule having a very high robust binding affinity to human ACE2. Relatively limited information is understood about the transcriptional regulation of ACE2. Hypoxic condition reduces the synthesis of ACE2, Further experimentation has shown that hypoxic condition induced HIF-1α protein leads to increases ACE synthesis which, prompts to rise the amount of Ang II and overall this process modulates the reduction in ACE2 synthesis with the help of Ang II. Activation of HIF-1 is related to numerous physiological and pathological processes. HIF-1 will manage ACE2 regulation and several natural components exhibit the role in activation and stabilization of the HIF-1α protein. The level of HIF-1α in cells gives us future opportunities for new, safe, and effective treatment options for the novel coronavirus.

Keywords:COVID-19; SARS-COV; HIF-1α Pathway; Influenza A Virus; Natural HIF-1α Activators


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Citation: Tulsi Patil.,et al. “Role of HIF 1 α in Covid-19 Disease".Acta Scientific Nutritional Health 5.6 (2021): 60-64.


Copyright: © 2021 Tulsi Patil., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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