Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Research Article Volume 5 Issue 2

Nutritional and Biochemical Composition of Amla (Emblica officinalis) and its Therapeutic Impact: A Review

Ali Ikram1, Waseem Khalid1*, Maryam Aziz1, Muhammad Adnan Arif2, Ravi Prakash Jha3, Muhammad Zubair Khalid1 , Chasheen Fizza1 , Muhammad Zarnoor Mehmood1 , Muhammad Haseeb1 , Muhammad Abdul Rahim1 , Sadia Naeem1 , Fatima Sultana1

1Institute of Home and Food Sciences, Government College University, Faisalabad, Pakistan
2National Institute of Food Science and Technology, University of Agricultural, Faisalabad, Pakistan
3Department of Community Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

*Corresponding Author: Waseem Khalid, Institute of Home and Food Sciences, Government College University, Faisalabad, Pakistan.

Received: December 25, 2020; Published: January 28, 2021

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Abstract

From ancient times, plants played a vital role in the development of mankind and was an exceptional source of natural medicine. The difficulty of the production of chemical medications, their side effects on safety, and the expense of rebellion have led researchers worldwide to concentrate on therapeutic plant science. Pakistan has a large collection of various plant species, with around 5,000 plants claiming to have important medicinal values. The papers published in recent decades on medicinal plants relate to the function of various plant bioactive composites commonly used in the cure of numerous human diseases. Bioactive compounds such as ascorbic acids, flavonoids, tannins, terpenoids, saponins, and several other components are reported to have been verified to have various medicinal activities, such as anti-inflammatory, antioxidant, antimicrobial, radiological, antitisinous, hepatoprotective, immune-modulatory, hypolipidemic and several other actions. The drug also has anti-cancer, antidepressant, antidiabetic, injury healing, antiulcerogenic, and so on. The present review article sums up the phytochemical components and pharmacology of the Emblica officinalis plant and its traditional application. Amla phyto-chemicals, including ellagic acid, emblicanine A, emblacani B, Gallic acid, phyllantine, quercetin and phyllantidine were found to have various biological activities such as antioxidants, antimicrobials, antiinlammative, antidiabetic, anti-radiation protection, chemopreventive and healing of wounds.

Keywords: Amla; Applications; Traditional Uses and Medicinal Effects

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References

  1. Baliga MS and Dsouza JJ. "Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer”. European Journal of Cancer Prevention3 (2011): 225-239.
  2. Sonkar N., et al. "Effect of cultivars, pretreatment and drying on physicochemical properties of Amla (Emblica officinalis) gratings”. Journal of Food Science and Technology3 (2020): 980-992.
  3. Jain SK and Khurdiya DS. "Vitamin C enrichment of fruit juice based ready-to-serve beverages through blending of Indian gooseberry (Emblica officinalis Gaertn.) juice”. Plant Foods for human nutrition2 (2004): 63-66.
  4. Choudhary M Grover K. "Amla (Emblica officinalis L.) Oil”. Fruit Oils: Chemistry and Functionality. Springer, Cham (2019): 875-882.
  5. Habib-ur-Rehman., et al. "Studies on the chemical constituents of Phyllanthus emblica”. Natural Product Research9 (2007): 775-781.
  6. Kumar KPS., et al. "Recent trends in potential traditional Indian herbs Emblica officinalis and its medicinal importance”. Journal of Pharmacognosy and Phytochemistry1 (2012): 18-28.
  7. Singh E., et al. "Phytochemistry, traditional uses and cancer chemopreventive activity of Amla (Phyllanthus emblica): the sustainer”. Journal of Applied Pharmacy Science1 (2011): 176-183.
  8. Khan KH. "Roles of Emblica officinalis in medicine-A review”. Botany Research International4 (2009): 218-228.
  9. El-Desouky., et al. "A new cytotoxic acylated apigenin glucoside from Phyllanthus emblica L”. Natural Product Research1 (2008): 91-95.
  10. Anjum A and Nafees H. "A Comprehensive Review on a Unani Dynamic Drug: Amla (Emblica officinalis)”. Asian Plant Research Journal (2020): 1-6.
  11. Veena K., et al. "The biochemical alterations following administration of Kalpaamruthaa and Semecarpus anacardium in mammary carcinoma”. Chemico-biological interactions1 (2006): 69-78.
  12. Sancheti G., et al. "Chemopreventive action of emblica officinalis on skin carcinogenesis in mice”. Asian Pacific Journal of Cancer Prevention: APJCP2 (2005): 197-201.
  13. Kaur S., et al. "The in vitro cytotoxic and apoptotic activity of Triphala—an Indian herbal drug”. Journal of Ethnopharmacology1 (2005): 15-20.
  14. Banu SM., et al. "Protective effect of Emblica officinalis ethanolic extract against 7, 12-dimethylbenz (a) anthracene (DMBA) induced genotoxicity in Swiss albino mice”. Human and Experimental Toxicology11 (2004): 527-531.
  15. Suryanarayana P., et al. "Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats”. Molecular Vision 13 (2007): 1291-1297.
  16. Singh MK., et al. "Anti-diabetic Effect of Emblica-officinalis (Amla) Against Arsenic Induced Metabolic Disorder in Mice”. Indian Journal of Clinical Biochemistry (2019): 1-9.
  17. Bhattacharya SK., et al. "Effect of bioactive tannoid principles of Emblica officinalis on ischemia-reperfusion-induced oxidative stress in rat heart”. Phytomedicine2 (2002): 171-174.
  18. Pramyothin P., et al. "The protective effects of Phyllanthus emblica Linn. extract on ethanol induced rat hepatic injury”. Journal of Ethnopharmacology3 (2006): 361-364.
  19. Tasduq SA., et al. "Protective effect of a 50% hydroalcoholic fruit extract of Emblica officinalis against anti‐tuberculosis drugs induced liver toxicity”. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives3 (2005): 193-197.
  20. Sultana S., et al. "Effect of Emblica officinalis (Gaertn) on CCl 4 induced hepatic toxicity and DNA synthesis in Wistar rats”. Indian Journal of Experimental Biology5 (2005): 430-436.
  21. Gautam A and Shukla S. "Emblica officinalis (Amla) leaf extract potentiates antibacterial activity of some antibiotics”. Journal of Pharmacognosy and Phytochemistry2 (2017): 233-236.
  22. Rajak S., et al. "Emblica officinalis causes myocardial adaptation and protects against oxidative stress in ischemic‐reperfusion injury in rats”. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives1 (2004): 54-60.
  23. Muthu PR., et al. "Amla (Emblica officinalis) improves hepatic and renal oxidative stress and the inflammatory response in hypothyroid female wistar rats fed with a high-fat diet”. Journal of Basic and Clinical Physiology and Pharmacology2 (2018): 175-184.
  24. Sairam KCHV., et al. "Antiulcerogenic effect of methanolic extract of Emblica officinalis: an experimental study”. Journal of Ethnopharmacology1 (2002): 1-9.
  25. Dhanalakshmi S., et al. "Protective effect of Triphala on cold stress-induced behavioral and biochemical abnormalities in rats”. Yakugaku Zasshi11 (2007): 1863-1867.
  26. Bariya AR., et al. "Assessment of Antioxidant and Sensory Properties of Amla (Emblica officinalis) Fruit and Seed Coat Powder Incorporated Cooked Goat Meat Patties”. International Journal Current Microbiology Applied Science7.7 (2018): 3306-3318.
  27. Anilakumar KR Nagaraj NS and Santhanam K. "Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by Emblica officinalis gaertn”. Indian Journal of Experimental Biology5 (2005): 450-454.
  28. Sandhya T., et al. "Protection against radiation oxidative damage in mice by Triphala”. Mutation Research/Genetic Toxicology and Environmental Mutagenesis1 (2006): 17-25.
  29. Kumaran A and Karunakaran RJ. "Nitric oxide radical scavenging active components from Phyllanthus emblica L”. Plant Foods for Human Nutrition1 (2006): 1.
  30. Srikumar R., et al. "Effect of Triphala on oxidative stress and on cell-mediated immune response against noise stress in rats”. Molecular and Cellular Biochemistry1-2 (2006): 67-74.
  31. Scartezzini P., et al. "Vitamin C content and antioxidant activity of the fruit and of the Ayurvedic preparation of Emblica officinalis Gaertn”. Journal of Ethnopharmacology1-2 (2006): 113-118.
  32. Rao TP., et al. "Amla (Emblica officinalis Gaertn.) extracts reduce oxidative stress in streptozotocin-induced diabetic rats”. Journal of Medicinal Food3 (2005): 362-368.
  33. Baliga MS., et al. "Hepatoprotective Effects of the Indian Gooseberry (Emblica officinalis Gaertn): A Revisit”. Dietary Interventions in Liver Disease. Academic Press (2019): 193-201.
  34. Bhattacharya SK., et al. "Effect of bioactive tannoid principles of Emblica officinalis on ischemia-reperfusion-induced oxidative stress in rat heart”. Phytomedicine2 (2002): 171-174.
  35. Sai RM., et al. "Cytoprotective activity of Amla (Emblica officinalis) against chromium (VI) induced oxidative injury in murine macrophages”. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives4 (2003): 430-433.
  36. Nosal'ova G., et al. "Antitussive activity of the fruit extract of Emblica officinalis Gaertn. (Euphorbiaceae)”. Phytomedicine6-7 (2003): 583-589.
  37. Al-Rehaily AJ., et al. "Gastroprotective effects of ‘Amla’ Emblica officinalis on in vivo test models in rats”. Phytomedicine6 (2002): 515-522.
  38. Vasudevan M and Parle M. "Memory enhancing activity of Anwala churna (Emblica officinalis Gaertn.): An Ayurvedic preparation”. Physiology and Behavior1 (2007): 46-54.
  39. Biswas NR., et al. "Evaluation of Ophthacare® eye drops—a herbal formulation in the management of various ophthalmic disorders”. Phytotherapy Research7 (2001): 618-620.
  40. Kim HJ., et al. "Influence of amla (Emblica officinalis Gaertn.) on hypercholesterolemia and lipid peroxidation in cholesterol-fed rats”. Journal of Nutritional Science and Vitaminology6 (2005): 413-418.
  41. Anila L and Vijayalakshmi N. "Flavonoids from Emblica officinalis and Mangifera indica—effectiveness for dyslipidemia”. Journal of Ethnopharmacology1 (2002): 81-87.
  42. Alam MI and Gomes A. "Snake venom neutralization by Indian medicinal plants (Vitex negundo and Emblica officinalis) root extracts”. Journal of Ethnopharmacology1 (2003): 75-80.
  43. Srikumar R., et al. "Evaluation of the growth inhibitory activities of Triphala against common bacterial isolates from HIV infected patients”. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives5 (2007): 476-480.
  44. Saeed S and Tariq P. "Antibacterial activities of Emblica officinalis and Coriandrum sativum against Gram negative urinary pathogens”. Pakistan Journal of Pharmaceutical Sciences 1 (2007): 32-35.
  45. Kaur S., et al. "The in vitro antimutagenic activity of Triphala—an Indian herbal drug”. Food and Chemical Toxicology4 (2002): 527-534.
  46. Singh DP., et al. "High‐performance liquid chromatography as a tool for the chemical standardisation of Triphala—an Ayurvedic formulation”. Phytochemical Analysis: An International Journal of Plant Chemical and Biochemical Techniques2 (2008): 164-168.
  47. Kumar MS., et al. "Triphala promotes healing of infected full-thickness dermal wound”. Journal of Surgical Research1 (2008): 94-101.
  48. Singh I., et al. "Radioprotection of Swiss albino mice by Emblica officinalis”. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives5 (2005): 444-446.
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Citation

Citation: Waseem Khalid., et al. “Nutritional and Biochemical Composition of Amla (Emblica officinalis) and its Therapeutic Impact: A Review".Acta Scientific Nutritional Health 5.2 (2021): 153-160.




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