Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Research Article Volume 4 Issue 12

Eating Quickly is Associated with Ultrasound-Diagnosed Non-Alcoholic Fatty Liver Disease in Japanese Adults

Koichiro Irie1, Tetsuji Azuma2, Takatoshi Yonenaga2, Minako Hada2, Kazutoshi Watanabe3, Fumiko Deguchi3, Akihiro Obora3, Takao Kojima3 and Takaaki Tomofuji2*

1Department of Oral Health and Preventive Dentistry, Meikai University School of Dentistry, Japan
2Department of Community Oral Health, School of Dentistry, Asahi University, Japan
3Asahi University Hospital, Japan

*Corresponding Author: Takaaki Tomofuji, Department of Community Oral Health, School of Dentistry, Asahi University, Mizuho, Japan.

Received: October 19, 2020; Published: November 18, 2020



  Non-alcoholic fatty liver disease (NAFLD) is a major global health problem. The aim of the present cross-sectional study was to investigate the relationship between eating quickly and NAFLD in Japanese adults. A total of 8556 participants underwent a health checkup. Abdominal ultrasonography was applied to diagnose NAFLD, and information on eating speed was obtained using a self-administrated questionnaire. Of the study participants, 2570 (30.0%) had ultrasound diagnosed NAFLD. The participants who reported eating quickly had a higher prevalence of NAFLD when compared to those who did not report eating quickly. The presence of NAFLD was significantly associated with male sex (odds ratio [OR] = 3.163, 95% confidence interval [CI] = 2.800 - 3.573), age ≥ 65 years (OR = 1.426, 95%CI = 1.076 - 1.889), high body mass index (≥ 25 kg/m2; OR = 9.615, 95%CI = 8.511 - 10.863), hypertension (OR = 1.659, 95%CI = 1.424 - 1.931), high hemoglobin A1c values (≥ 6.5%; OR = 4.096, 95%CI = 3.080 - 5.446), the presence of regular exercise habits (OR = 0.605, 95%CI = 0.522 - 0.701), and eating quickly (OR = 1.146, 95%CI = 1.023 - 1.283) after adjusting for confounding factors. These results indicated that lifestyle factors, including eating quickly, is positively associated with NAFLD in Japanese adults independently of overweight and obesity.

Keywords: Eating Behaviors; Eating Speed; Fatty Liver; Cross-Sectional Study; Japanese



  1. Perdomo CM., et al. “Impact of nutritional changes on nonalcoholic fatty liver disease”. Nutrients3 (2019): 677.
  2. Marchesini G., et al. “Association of nonalcoholic fatty liver disease with insulin resistance”. American Journal of Medicine5 (1999): 450-455.
  3. Marchesini G., et al. “Nonalcoholic fatty liver disease: A feature of the metabolic syndrome”. Diabetes8 (2001): 1844-1850.
  4. Eguchi Y., et al. “Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study”. Journal of Gastroenterology5 (2012): 586-595.
  5. Kaur J. “A comprehensive review on metabolic syndrome”. Cardiology Research and Practice 2014 (2014): 943162.
  6. Stefan N., et al. “Non-alcoholic fatty liver disease: Causes, diagnosis, cardiometabolic consequences, and treatment strategies”. Lancet Diabetes and Endocrinology4 (2019): 313-324.
  7. Zou TT., et al. “Lifestyle interventions for patients with nonalcoholic fatty liver disease: a network meta-analysis”. European Journal of Gastroenterology7 (2018): 747-755.
  8. Maria Garralda-Del-Villar., et al. “Healthy lifestyle and incidence of metabolic syndrome in the SUN cohort”. Nutrients1 (2019): 65.
  9. Eslamparast T., et al. “Dietary composition independent of weight loss in the management of non-alcoholic fatty liver disease”. Nutrients8 (2017): 800.
  10. Wong VW., et al. “Beneficial effects of lifestyle intervention in non-obese patients with non-alcoholic fatty liver disease”. Journal of Hepatology6 (2018): 1349-1356.
  11. Ohkuma T., et al. “Association between eating rate and obesity: a systematic review and meta-analysis”. International Journal of Obesity11 (2015): 1589-1596.
  12. Carnell S and Wardle J. “Measuring behavioural susceptibility to obesity: validation of the child eating behaviour questionnaire”. Appetite1 (2007): 104-113.
  13. Guertin TL., et al. “Eating behavior of bulimics, self-identified binge eaters, and non-eating-disordered individuals: what differentiates these populations?” Clinical Psychology Review1 (1999): 1-23.
  14. Otsuka R., et al. “Eating fast leads to obesity: findings based on self-administered questionnaires among middle-aged Japanese men and women”. Journal of Epidemiology3 (2006): 117-124.
  15. Hill AJ. “Obesity and eating disorders”. Obesity Reviews1 (2007): 151-155.
  16. Chitturi S., et al. “Non-alcoholic fatty liver disease in the Asia-pacific region: Definitions and overview of proposed guidelines”. Journal of Gastroenterology and Hepatology6 (2007): 778-787.
  17. Iwasaki T., et al. “Self-reported behavior of eating quickly is correlated with visceral fat area in Japanese non-obese adults”. Asia Pacific Journal of Clinical Nutrition1 (2019): 92-98.
  18. Mochizuki K., et al. “Self-reported faster eating is positively associated with accumulation of visceral fat in middle-aged apparently healthy Japanese men”. European Journal of Nutrition5 (2014): 1187-1194.
  19. K., et al. “Prevalence and correlates of hypertension among Japanese adults, 1975 to 2010”. International Journal of Environmental Research and Public Health 15.8 (2018): 1645.
  20. Maruyama K., et al. “The joint impact on being overweight of self reported behaviours of eating quickly and eating until full: cross sectional survey”. British Medical Journal 337 (2008): a2002.
  21. Okada C., et al. “The association of having a late dinner or bedtime snack and skipping breakfast with overweight in Japanese women”. Journal of Obesity (2019): 2439571.
  22. Sun Y., et al. “Lifestyle and overweight among Japanese adolescents: the Toyama Birth Cohort Study”. Journal of Epidemiology6 (2009): 303-310.
  23. Cao H. “Adipocytokines in obesity and metabolic disease”. Journal of Endocrinology2 (2014): T47-T59.
  24. Achila OO., et al. “Factors associated with poor glycemic and lipid levels in ambulatory diabetes mellitus type 2 patients in Asmara, Eritrea: A cross-sectional study”. Journal of Diabetes Research 2020 (2020): 5901569.
  25. Vaněčková I., et al. “Obesity-related hypertension: possible pathophysiological mechanisms”. Journal of Endocrinology3 (2014): R63-R78.
  26. Matsuzawa, Y. “Specific health guidance, the nationwide lifestyle intervention program targeting metabolic syndrome, seems to be successful in Japan”. Journal of Atherosclerosis and Thrombosis4 (2018): 304-305.
  27. Ekuni D., et al. “Association between intensive health guidance focusing on eating quickly and metabolic syndrome in Japanese middle-aged citizens”. Eating and Weight Disorders1 (2020): 91-98.
  28. Nagahama S., et al. “Self-reported eating rate and metabolic syndrome in Japanese people: cross-sectional study”. BMJ Open9 (2014): e005241.
  29. Gouda M., et al. “Association between eating habits and glycemic control and obesity in Japanese workers with type 2 diabetes mellitus”. Diabetes, Metabolic Syndrome and Obesity 11 (2018): 647-658.




Citation: Takaaki Tomofuji., et al. “Eating Quickly is Associated with Ultrasound-Diagnosed Non-Alcoholic Fatty Liver Disease in Japanese Adults".Acta Scientific Nutritional Health 4.12 (2020): 28-34.


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