Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Review Article Volume 4 Issue 11

Lipedema and Nutrition: What’s the Link?

Cannataro Roberto1,2* and Erika Cione1,2

1Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy
2Galscreen Srl University of Calabria, Rende (CS), Italy

*Corresponding Author: Cannataro Roberto, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy.

Received: August 03, 2020; Published: October 28, 2020

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Abstract

  Lipedema is a dysfunction of the subcutaneous adipose tissue (SAT), it is characteristic of women, although it is reported in rare cases also in men, it was described for the first time in 1940, with a better characterization in 1951, although this is often still confused with classic obesity. It affects the lower and upper limbs, the buttocks, usually sparing the feet and trunk. It is classified into 5 levels, according to the area of the body affected by the dysfunction. The tissues are nodular to the touch and this, among other things, suggests an inflammatory phenomenon. The treatments concern surgery (bariatric and liposuction), compression garments, physiotherapy. The nutritional approach often has little or no efficacy, probably because the adipose tissue is inflamed, therefore not very responsive if the inflammation itself is not managed. An approach that is having an interesting response is the ketogenic diet (a nutritional approach that provides for a carbohydrate intake of less than 30g per day), in previous work we have demonstrated the marked anti-inflammatory and antioxidant action of this nutritional approach, which could prove effective in assist the treatment of lipedema.

Keywords:SAT; Lipedema; Ketogenic Diet; Inflammation

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References

  1. Reich -Sch upke S., et al. “S1 guideli nes: lipedema”. Journal der Deutschen Dermatologischen Gesellschaft 15 (2017): 758-767.
  2. Halk AB and Damstra RJ. “First Dutch guidelines on lipedema using the international classification of functioning, disability and health”. Phlebology 32 (2017): 152-159.
  3. Lipedema and title=Lipedema and search=Disease_Search_Simple (2020).
  4. Buck DW and Herbst KL. “Lipedema: A Relatively Common Disease with Extremely Common Misconceptions”. Plastic and Reconstructive Surgery Global Open 9 (2016): e1043.
  5. Beltran K and Herbst KL. “Differentiating lipedema and Dercum's disease”. International Journal of Obesity 2 (2017): 240-245.
  6. Herbst KL. “Subcutaneous Adipose Tissue Diseases: Dercum Disease, Lipedema, Familial Multiple Lipomatosis, and Madelung Disease”. In: Feingold KR, Anawalt B, Boyce A, et al., eds. Endotext. South Dartmouth (MA): MDText.com, Inc (2000).
  7. Corda D. “Linfedema and Lipedema, get to know them, recognize them, cure them”. Ed Minerva Medica (2017).
  8. Buso G., et al. “Lipedema: A Call to Action!”. Obesity10 (2019): 1567-1576.
  9. Reilly SM and Saltiel AR. “Adapting to obesity with adipose tissue inflammation”. Nature Reviews Endocrinology 11 (2017): 633-643.
  10. Engin A. “The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation”. Advances in Experimental Medicine and Biology 960 (2017): 221-245.
  11. Klöting N and Blüher M. “Adipocyte dysfunction, inflammation and metabolic syndrome”. Reviews in Endocrine and Metabolic Disorders 4 (2014): 277-287.
  12. Henriques Felipe., et al. “Adipose Tissue Inflammation and Metabolic Disorders” (2019).
  13. Medzhitov R. “Origin and physiological roles of inflammation”. Nature 7203 (2008): 428-435.
  14. Weiss U. “Inflammation”. Nature7203 (2008): 427.
  15. Medzhitov R. “Inflammation 2010: new adventures of an old flame”. Cell 6 (2010): 771-776.
  16. Kulinsky VI. “Biochemical aspects of inflammation”. Biochemistry6 (2007): 595-607.
  17. Mueller K. “Inflammation. Inflammation's yin-yang. Introduction”. Science6616 (2013): 155.
  18. Cannataro R., et al. “Ketogenic Diet and microRNAs Linked to Antioxidant Biochemical Homeostasis”. Antioxidants8 (2019): 269.
  19. Risorse CHIRURGIA.
  20. Asadipooya K and Uy EM. “Advanced Glycation End Products (AGEs), Receptor for AGEs, Diabetes, and Bone: Review of the Literature”. Journal of the Endocrine Society 10 (2019): 1799-1818.
  21. Nowotny K., et al. “Advanced glycation end products and oxidative stress in type 2 diabetes mellitus”. Biomolecules1 (2015): 194-222.
  22. Cardoso-Silva D., et al. “Intestinal Barrier Function in Gluten-Related Disorders”. Nutrients10 (2019): 2325.
  23. Fassio F., et al. “Lactose Maldigestion, Malabsorption, and Intolerance: A Comprehensive Review with a Focus on Current Management and Future Perspectives”. Nutrients11 (2018): 1599.
  24. Cannataro R., et al. “Nutritional Supplements Use in Physically Active Italian Adults: What Do They Use and How Are They Influenced?” International Journal of Medical Research and Health Sciences 2 (2019).
  25. Cannataro R and Cione E. “Management of Diabetes and Nutritional Supplements”. International Journal of Diabetes and Metabolic Disorders 3 (2020): 48.
  26. Calder PC. “Omega-3 fatty acids and inflammatory processes: from molecules to man”. Biochemical Society Transactions 5 (2017): 1105-1115.
  27. Gao H., et al. “Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis”. Lipids in Health and Disease 1 (2017): 131.
  28. Carracedo M., et al. “The resolution of inflammation through omega-3 fatty acids in atherosclerosis, intimal hyperplasia, and vascular calcification”. Seminars in Immunopathology 6 (2019): 757-766.
  29. Piccolella S., et al. “Nutraceutical polyphenols: New analytical challenges and opportunities”. Journal of Pharmaceutical and Biomedical Analysis 175 (2019): 112774.
  30. Ruskovska T., et al. “Polyphenols in human nutrition: from the In vitro antioxidant capacity to the beneficial effects on cardiometabolic health and related inter-individual variability - an overview and perspective”. British Journal of Nutrition 3 (2020): 241-254.
  31. Cione E., et al. “Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation”. Molecules1 (2019): 63.
  32. Priglinger E., et al. “SVF-derived extracellular vesicles carry characteristic miRNAs in lipedema”. Scientific Reports 1 (2020): 7211.
  33. Cannataro R., et al. “Ketogenic Diet and microRNAs Linked to Antioxidant Biochemical Homeostasis”. Antioxidants8 (2019): 269.

 

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Citation

Citation: Cannataro Roberto and Erika Cione. “Lipedema and Nutrition: What’s the Link?".Acta Scientific Nutritional Health 4.11 (2020): 86-89.




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