Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Research Article Volume 4 Issue 11

The Relationship between Allergic Pollinosis and Low Salivary Levels of Secretory IgA in Adults

Tetsuro Yamamoto1, Tadao Enomoto2, Akira Tsuda3, Hisayoshi Okamura4, Tatsuya Honda1, Shaw Watanabe5 and Hideyo Yamaguchi1*

1Research Center, TTC Co., Ltd., Tokyo, Japan
2NPO Japan Health Promotion Supporting Network, Wakayama, Japan
3Department of Psychology, Kurume University, Kurume, Japan
4Cognitive and Molecular Institute of Brain Diseases Kurume University, Kurume, Japan
5LifeScience Promoting Association, Tokyo University of Agriculture, Tokyo, Japan

*Corresponding Author: Hideyo Yamaguchi, Research Center, TTC Co., Ltd., Tokyo, Japan.

Received: September 23, 2020; Published: October 07, 2020

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Abstract

  Secretary IgA is a key element of intestinal immunity. Low levels of secretory IgA (SIgA) and development of allergy in infants were often reported, but it is not in adults. Saliva and serum were simultaneously analyzed from 20 adult patients with Cedar pollinosis aged 22-53 years and 22 non-allergic control adults aged 25-65 years. The mean salivary level of SIgA for JCP patients was significantly lower than the value for control subjects (58.1 ± 8.8 ug/ml vs. 68.6 ± 12.1 ug/ml). On the contrary, Cedar pollen specific IgE in the serum was 11.5 UA/ml, 4.05, 23.1, respectively (median, 25th-75th percentile) in pollinosis group, while it was <0.34 UA/ml (detection limit) in control group. Low levels of salivary SIgA in adults was associated with increased allergic manifestations.

Keywords: Allergic Pollinosis; Japanese Cedar Pollen; Saliva; Secretory IgA, Specific IgE Antibodies

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References

  1. Brandtzaeg P., et al. “Production and secretion of immunoglobulins in the gastrointestinal tract”. Annals of Allergy 59 (1987): 21-39.
  2. Brandtzaeg P. “The role of humoral mucosal immunity in the induction and maintenance of chronic airway infections”. American Journal of Respiratory and Critical Care Medicine 151 (1995): 2081-2087.
  3. Brandtzaeg P., et al. “Regional specialization in the mucosal immune system: what happens in the microcompartments?” Immunology Today 20 (1999): 141-151.
  4. Johansen F., et al. “The J chain is essential for polymeric Ig receptor-mediated epithelial transport of IgA”. Journal of Immunology 167 (2001): 5185-5192.
  5. Soothill JF., et al. “Predisposing factors and the development of reaginic allergy in infancy”. The Journal of Allergy and Clinical 6 (1976): 305-319.
  6. Kilian M., et al. “Perturbation of mucosal immune defense mechanisms by bacterial IgA proteases”. Bulletin Européen de Physiopathologie Respiratoire 19 (1983): 99-104.
  7. Burks AW and Steele RW. “Selective IgA deficiency”. Annals of Allergy 57 (1986): 3-9.
  8. Payette K and Weiss NS. “Salivary IgA levels in atopic children”. Annals of Allergy 39 (1977): 328-331.
  9. Van Asperen PP., et al. “The relationship between atopy and salivary IgA deficiency in infancy”. Clinical and Experimental Immunology 62 (1985): 753-757.
  10. Calvo M., et al. “Evaluation of secretory IgA in childhood respiratory diseases”. Allergologia et Immunopathologia 16 (1988): 157-161.
  11. Böttcher MF., et al. “Total and allergen-specific immunoglobulin A levels in saliva in relation to the development of allergy in infants up to 2 years of age”. Clinical and Experimental Allergy 32 (2002): 1293-1298.
  12. Gleeson M., et al. “Development of bronchial hyperreactivity following transient absence of salivary IgA”. American Journal of Respiratory and Critical Care Medicine 153 (1996): 1785-1789.
  13. Okuda M. “Epidemiology of Japanese cedar pollinosis throughout Japan”. Annals of Allergy, Asthma and Immunology 91 (2003): 288-296.
  14. Kohler PF and Farr RS. “Quantitative comparison of immunoglobulins in atopic (reaginic) and nonatopic (nonreaginic) individuals: Higher γD levels in atopic sera”. The Journal of Allergy 39 (1967): 311-322.
  15. Plebani A., et al. “Different role of secretory IgA in the pathogenesis of RAST-positive and RAST-negative atopic dermatitis”. Clin Allergy 12 (1982): 403-407.
  16. Brasher GW. “Salivary IgA in children with atopic disease”. Annals of Allergy 29 (1971): 422-427.
  17. Hobday JD., et al. “A comparison of the immunoglobulins IgA, IgG and IgE in nasal secretions from normal and asthmatic children”. Clinical and Experimental Immunology 9 (1971): 577-583.
  18. Salvaggio J., et al. “Salivary, nasal wash and sputum IgA concentrations in atopic and non-atopic individuals”. The Journal of Allergy and Clinical Immunology 51 (1973): 335-343.
  19. Imayama S., et al. “Reduced secretion of IgA to skin surface of patients with atopic dermatitis”. The Journal of Allergy and Clinical Immunology 94 (1994): 195-200.
  20. Toshitani A., et al. “Reduced amount of secretory component of IgA secretion in tears of patients with atopic dermatitis”. The Journal of Dermatological Science 19 (1999): 134-138.
  21. Taylor B., et al. “Transient IgA deficiency and pathogenesis of infantile atopy”. Lancet 2 (1973): 111-113.
  22. Stokes CR., et al. “Immune exclusion is a function of IgA”. Nature 255 (1973): 745-746.
  23. Brandtzaeg P. “Molecular and cellular aspects of the secretory immunoglobulin system”. APMIS 103 (1995): 1-19.
  24. Turk A., et al. “Nasal secretory antibody to inhalant allergens in allergic and non-allergic patients”. Immunology 19 (1970): 85-95.
  25. Georgitis JM., et al. “Local intranasal immunotherapy for grass-allergic rhinitis”. The Journal of Allergy and Clinical Immunology 71 (1983): 71-76.
  26. Gurgenidze GV., et al. “Comparative estimation of general and local humoral immunity indicators in connection with local immunotherapeutic treatment”. Allergologia et Immunopathologia 18 (1990): 325-329.
  27. Mero A., et al. “IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training”. Journal of Applied Physiology 93 (2002): 732-739.
  28. Crooks CV., et al. “The effect of bovine colostrum supplementation on salivary IgA in distance runners”. International Journal of Sport Nutrition and Exercise Metabolism 16 (2006): 47-64.
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Citation

Citation: Hideyo Yamaguchi., et al. “The Relationship between Allergic Pollinosis and Low Salivary Levels of Secretory IgA in Adults".Acta Scientific Nutritional Health 4.11 (2020): 16-21.




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