Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Research Article Volume 4 Issue 9

Ketogenic Diet Modifies the Expression of MicroRNAs Linked to Migraine

Roberto Cannataro1*, Maria Cristina Caroleo1, Antonio Siniscalchi2, Luca Gallelli3, Giovambattista De Sarro3 and Erika Cione1

1Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy
2Stroke Unit, Neurology Unit, “Annunziata” Hospital, Cosenza, Italy
3Department of Health Sciences, University of Catanzaro, and Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini Hospital, Catanzaro, Italy

*Corresponding Author: Roberto Cannataro, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy.

Received: July 22, 2020; Published: August 24, 2020

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Abstract

Epidemiological studies have emphasized the relationship between migraine and obesity also pointing out its prevalence in the female sex. The mechanisms promoting pain migraine in obese subjects prone to this neurological disorder is multifactorial, among these the overproduction of soluble mediators favoring neural inflammation, psychological and behavioral risk factors. The ketogenic diet (KD) is a well-recognized as a therapeutic option for refractory pediatric epilepsy and a promising prophylactic treatment for episodic and chronic migraine in the adult. Performing a pilot study on the capability of KD to modulate a plethora of 800 microRNAs (miRs), a group of female obese subjects, 6 of 18 self-reported a reduction of the frequency and the intensity of migraine-pain attacks. Therefore, we check for miRs linked to migraines. The effects of KD seem to be mediated by specific serum hsa-miR-590-5p, hsa-miR-660-3p modulation.

Keywords: Ketogenic Diet; Migraine; MicroRNAs

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Citation

Citation: Roberto Cannataro.,et al. “Ketogenic Diet Modifies the Expression of MicroRNAs Linked to Migraine". Acta Scientific Nutritional Health 4.9 (2020): 34-41.




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