Background: Obesity and associated disorders have reached an epidemic proportions worldwide. Studies have linked the condition to genetics as well as with lifestyle disorder. Microbial insights have helped in the understanding of gut microbiota contribution to many human health conditions.

Methodology: A literature search of electronic databases was performed, using the search syntax: Gut microbiota, diet, obesity, pathogenesis of obesity to build and summarize the broad view of the present paper.

Summary: The review discusses the pathogenesis of obesity, interactions of gut microbiota and diet in obesity and the effect of the dietary components intervention on the human health status. Reviewing the studies, it was evident that gut microbes have a significant role and can impact host metabolism via signalling pathways in the gut, with effects on inflammation, insulin resistance, and deposition of energy in fat stores. The host genetics, stress, age and gender contribute to the host-microbiota interactions in obesity. The macronutrients, micronutrients, minerals, fats, bioactive nutrients and food additives in diet interact with the gut microbiota to produce metabolites that modulate host metabolism in both beneficial and detrimental ways. The review attempted to evaluate the impact of dietary components on gut microbiota to disease onset, further identifying the research challenges and discuss the future consideration in clinical interventions that can be translated into clinical practice. Multidisciplinary research in this field will be helpful to provide therapeutic potential of gut microbes in metabolic disorders and obesity treatment.

Keywords: Nutrition; Weight; Microbiota; Gastrointestinal Tract (GIT); Host; Microbiome

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Citation

Citation: Lima Hazarika., et al. “Understanding the Effects of Diet on Gut Microbiota in Obesity: A Review". Acta Scientific Nutritional Health 4.5 (2020): 19-27.

Copyright

Copyright: © 2020 Lima Hazarika., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.