Ginger is revered in Ayurvedic medicine, where it is known as ‘mahaoushadha’ (the Great medicine) and as ‘vishwabheshaj’ or ‘vishwaaushadha’ (the Universal medicine). Since antiquity, ginger or Zingiber officinale, has been used by humans all over the world for medicinal purposes as well as spice condiments to enhance flavor in cooking. While ginger is rich in various chemical constituents, including phenolic compounds, terpenes, polysaccharides, lipids, organic acids, and raw fibers the health benefits of ginger are mainly attributed to its phenolic compounds, such as gingerol and shogaol and paradol.

References

1. Mao QQ., et al. “Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe)”. Foods 8.6 (2019). pii: E185.
2. Mohd Yusof YA. “Gingerol and Its Role in Chronic Diseases”. Advances in Experimental Medicine and Biology 929 (2016): 177-207.
3. Mohd Sahardi NFN and Makpol S. “Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence”. Evidence-Based Complementary and Alternative Medicine (2019): 5054395.
4. Zhang M., et al. “Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis”. Journal of Crohn's and Colitis 12.2 (2018): 217-229.
5. Mahomoodally MF., et al. “Ginger and its active compounds in cancer therapy: From folk uses to nano-therapeutic applications”. Seminar on Cancer Biology (2019): pii: S1044-579X (19)30213-5.
6. Deng X., et al. “Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol”. Journal of Food Science 84.8 (2019): 2101-2111.
7. Munir J., et al. “Exosomes in Food: Health Benefits and Clinical Relevance in Diseases”. Advances in Nutrition (2019): pii: nmz123.
8. Mu J., et al. “Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles”. Molecular Nutrition and Food Research 58 (2014): 1561-1573.
9. Zhuang X., et al. “Ginger-derived nanoparticles protect against alcohol-induced liver damage”. Journal of Extracellular Vesicles 4 (2015): 28713.
10. Sung J., et al. “Isolation, Purification, and Characterization of Ginger-derived Nanoparticles (GDNPs) from Ginger, Rhizome of Zingiber officinale”. Bio Protocol 9.19 (2019). pii: e3390.
11. Chen X., et al. “Exosome-like Nanoparticles from Ginger Rhizomes Inhibited NLRP3 Inflammasome Activation”. Molecular Pharmaceutics 16.6 (2019): 2690-2699.
12. Teng Y., et al. “Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota”. Cell Host and Microbe 24.5 (2018): 637-652.e8.
13. Sundaram K., et al. “Plant-Derived Exosomal Nanoparticles Inhibit Pathogenicity of Porphyromonas gingivalis”. iScience 21 (2019): 308-327.

Citation

Citation: M Balasubramanyam. “Sweet Excitements on Ginger Exosomal Therapeutics!". Acta Scientific Nutritional Health 4.3 (2020): 139-140.

Copyright

Copyright: © 2020 M Balasubramanyam. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.