Augustine I Airaodion1*, Ime U Akaninyene2, Kenneth O Ngwogu3, John A Ekenjoku4 and Ada C Ngwogu5
1Department of Biochemistry, Federal University of Technology, Owerri, Imo State, Nigeria
2Department of Physiology, Arthur Jarvis University, Akpabuyo, Cross-River State, Nigeria
3Department of Pathology, Abia State University, Uturu, Nigeria
4Department of Pharmacology and Therapeutics, Abia State University, Uturu, Nigeria
5Department of Microbiology, Abia State University, Uturu, Nigeria
*Corresponding Author: Augustine I Airaodion, Department of Biochemistry, Federal University of Technology Owerri, Imo State, Nigeria.
Received: February 05, 2020; Published: February 20, 2020
The aim of this study is to evaluate the hypolipidaemic and antidiabetic potency of Allium cepa bulb in alloxan-induced diabetic rats. To achieve this, fresh onion bulbs were purchased from a local market in Owerri, Nigeria and the juice extracted. Thirty-six male albino rats were induced intraperitoneally with alloxan. The rats were grouped into six groups of six animals per group: Group A was not induced with alloxan and untreated, group B animals were induced but not treated, group C animals were treated with glibenclaimide, group D, E and F animals were induced and treated with 1, 2 and 3 mL/100g body weight of A. cepa juice respectively. The administration was via oral route for 14 days. The animal’s blood sugar levels were determined using glucometer. The lipid profile parameters were determined using standard methods. The animals administered with 1, 2 and 3 mL/100g bodyweight of A. cepa showed significant decrease (P < 0.05) in blood sugar level compared to the untreated animals. The decrease in the blood glucose level of the animals following the administration of the juice suggested that the plant possesses antidiabetic effects. The juice of A. cepa produces hypolipidaemic effect and this is evident as there were significant decrease in plasma total cholesterol, triglycerides, LDL-cholesterol and an increase in HDL-cholesterol in the treated groups compared to the untreated group. This is an indication that A. cepa bulb possessed hypolipidaemic and antidiabetic potency in alloxan-induced diabetic rats.
Keywords: Allium cepa Bulb; Alloxan-Induced Diabetes; Fasting Blood Sugar; Lipid Profile
Citation: Augustine I Airaodion., et al. “Hypolipidaemic and Antidiabetic Potency of Allium cepa (Onions) Bulb in Alloxan-Induced Diabetic Rats". Acta Scientific Nutritional Health 4.3 (2020): 73-80.
Copyright: © 2020 Augustine I Airaodion., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.