Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Research Article Volume 4 Issue 2

Higher Serum Levels of Indirect Bilirubin and Polyunsaturated Fatty Acids in Japanese Centenarians with Better Performance and Nutrition Status

Yuji Aoki*

Matsumoto University, Graduate School of Health Science, Japan

*Corresponding Author: Yuji Aoki, Matsumoto University, Graduate School of Health Science, Japan.

Received: January 21, 2020; Published: January 31, 2020



  The involvement of oxidative stress in aging and age-related diseases is well known. It is of interest that indirect (unconjugated) bilirubin as an antioxidant and polyunsaturated fatty acids susceptible to peroxidation can be associated with longevity. Twenty-seven community-dwelling centenarians were studied in relation to performance and nutrition status. The centenarians with better performance status had higher serum levels of total protein, albumin, creatinine, indirect bilirubin, total cholesterol, low-density lipoprotein cholesterol, triglyceride and dihomo-γ-linolenic acid, in addition to higher blood pressure. Serum albumin significantly correlated positively with total protein, iron, total cholesterol, low-density lipoprotein cholesterol, dihomo-γ-linolenic acid and eicosapentaenoic acid, and negatively with high-sensitivity C-reactive protein. Serum indirect bilirubin significantly correlated with serum albumin, dihomo-γ-linolenic acid, arachidonic acid and docosahexaenoic acid. Serum indirect bilirubin level was associated with the degree of physical activity in Japanese centenarians. Considering antioxidant effects of indirect bilirubin and health benefits of polyunsaturated fatty acids as well as the relevant literature, the present study suggests that centenarians with better performance status have a higher content of polyunsaturated fatty acids protected from peroxidation.

Keywords: Centenarians; Performance Status; Bilirubin; Polyunsaturated Fatty Acids; Oxidative Stress



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Citation: Yuji Aoki. “Higher Serum Levels of Indirect Bilirubin and Polyunsaturated Fatty Acids in Japanese Centenarians with Better Performance and Nutrition Status". Acta Scientific Nutritional Health 4.2 (2020): 179-182.


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