Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Research Article Volume 4 Issue 2

Higher Serum Levels of Indirect Bilirubin and Polyunsaturated Fatty Acids in Japanese Centenarians with Better Performance and Nutrition Status

Yuji Aoki*

Matsumoto University, Graduate School of Health Science, Japan

*Corresponding Author: Yuji Aoki, Matsumoto University, Graduate School of Health Science, Japan.

Received: January 21, 2020; Published: January 31, 2020

×

Abstract

  The involvement of oxidative stress in aging and age-related diseases is well known. It is of interest that indirect (unconjugated) bilirubin as an antioxidant and polyunsaturated fatty acids susceptible to peroxidation can be associated with longevity. Twenty-seven community-dwelling centenarians were studied in relation to performance and nutrition status. The centenarians with better performance status had higher serum levels of total protein, albumin, creatinine, indirect bilirubin, total cholesterol, low-density lipoprotein cholesterol, triglyceride and dihomo-γ-linolenic acid, in addition to higher blood pressure. Serum albumin significantly correlated positively with total protein, iron, total cholesterol, low-density lipoprotein cholesterol, dihomo-γ-linolenic acid and eicosapentaenoic acid, and negatively with high-sensitivity C-reactive protein. Serum indirect bilirubin significantly correlated with serum albumin, dihomo-γ-linolenic acid, arachidonic acid and docosahexaenoic acid. Serum indirect bilirubin level was associated with the degree of physical activity in Japanese centenarians. Considering antioxidant effects of indirect bilirubin and health benefits of polyunsaturated fatty acids as well as the relevant literature, the present study suggests that centenarians with better performance status have a higher content of polyunsaturated fatty acids protected from peroxidation.

Keywords: Centenarians; Performance Status; Bilirubin; Polyunsaturated Fatty Acids; Oxidative Stress

×

References

  1. Aoki Y., et al. “Leukocyte telomere length and serum levels of high-molecular-weight adiponectin and dehydroepiandrosterone-sulfate could reflect distinct aspects of longevity in Japanese centenarians”. Gerontology and Geriatric Medicine 3 (2017): 1-6.
  2. Liguori I., et al. “Oxidative stress, aging, and diseases”. Clinical Interventions in Aging 13 (2018): 757-772.
  3. Luo J., et al. “Ageing, age-related diseases and oxidative stress: What to do next?”. Ageing Research Reviews 57 (2020): 100982. 
  4. Neuzil J., et al. “Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation”. The Journal of Biological Chemistry 269.24 (1994): 16712-16719.
  5. DiNicolantonio JJ., et al. “Antioxidant bilirubin works in multiple ways to reduce risk for obesity and its health complications”. Open Heart 5 (2018): e000914.
  6. Sorensen JB., et al. “Performance status assessment in cancer patients. An inter-observer variability study”. British Journal of Cancer 67.4 (1993): 773-775.
  7. Delgado-Rodrigues M., et al. “Cholesterol and serum albumin levels as predictors of cross infection, death, and length of hospital stay”. Archives of Surgery 137.7 (2002): 805-812.
  8. Han S., et al. “The prognostic role of preoperative albumin levels in glioblastoma patients”. BMC Cancer 15 (2015): 108.
  9. Zhang Z., et al. “Evaluation of blood biomarkers associated with risk of malnutrition in older adults: a systematic review and meta-analysis”. Nutrients 9.8 (2017): 829.
  10. Baxmann A. C., et al. “Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystatin C”. Clinical Journal of the American Society of Nephrology 3.2 (2008): 348-354.
  11. Thongprayoon C., et al. “Serum creatinine level, a surrogate of muscle mass, predicts mortality in critically ill patients”. Journal of Thoracic Disease 8.5 (2016): E305-E311.
  12. Kusunoki H., et al. “Relationship between sarcopenia and the serum creatinine/cystatin C ratio in Japanese rural community-dwelling older adults”. Journal of Cachexia, Sarcopenia and Muscle - Clinical Reports 3.1 (2018): e00057.
  13. Hamazaki K., et al. “Chapter 1, cholesterol and mortality”. Annals of Nutrition and Metabolism 66.suppl 4 (2015): 3-13.
  14. Ravnskov U., et al. “Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review”. British Medical Journal Open 6 (2016): e010401.
  15. Stocker R., et al. “Bilirubin is an antioxidant of possible physiological importance”. Science 234.4792 (1987): 1043-1046.
  16. Datla SR., et al. “Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress”. Hypertension 50 (2007): 636-642.
  17. Horsfall LJ., et al. “Gilbert’s syndrome and the risk of death: a population-based cohort study”, Journal of Gastroenterology and Hepatology 28.10 (2013): 1643-1647.
  18. Wagner KH., et al. “Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases”. Clinical Science (London) 129.1 (2015): 1-25.
  19. Inoguchi T., et al. “Serum bilirubin level is a strong predictor for disability in activities in daily living (ADL) in Japanese elderly patients with diabetes”. Scientific Reports 9 (2019): 7069.
  20. Stocker R., et al. “Antioxidant activity of albumin-bound bilirubin”. Proceedings of the National Academy of Sciences of the United States of America 84.16 (1987): 5918-5922.
  21. Whelan J. “(n-6) and (n-3) Polyunsaturated fatty acids and the aging brain: food for thought”. Journal of Nutrition 138.12 (2008): 2521-2522.
  22. Tallima H., et al. “Arachidonic acid: physiological roles and potential health benefits - a review”. Journal of Advanced Research 11 (2018): 33-41.
  23. Naudi A., et al. “Membrane lipid unsaturation as physiological adaptation to animal longevity”. Frontiers in Physiology 4 (2013): 372.
  24. Jove M., et al. “A stress-resistant lipidomic signature confers extreme longevity to humans”. The Journals of Gerontology Series A Biological Sciences and Medical Sciences 27.1 (2017): 30-37.
×

Citation

Citation: Yuji Aoki. “Higher Serum Levels of Indirect Bilirubin and Polyunsaturated Fatty Acids in Japanese Centenarians with Better Performance and Nutrition Status". Acta Scientific Nutritional Health 4.2 (2020): 01-04.



Member In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for March Issue
    The last date for submission of articles for regular Issues is February 29, 2020.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US