Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Research Article Volume 4 Issue 1

Phytochemical Content, Antioxidant, Anti-inflammatory Activities and Wound Healing Properties of Freeze-Dried Fruits

Francisca Pereira de Moraes1, Jia Xiong2, Katia Cristina Borges1, Roberta Targino Hoskin1, Debora Esposito3*

1Laboratory of Food Bioactive Compounds, Chemical Engineering Department, Federal University of Rio Grande do Norte (UFRN), Campus Central, Brazil
2Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis, United States of America
3Plants for Human Health Institute, Department of Animal Science, North Carolina State University, Kannapolis, United States of America

*Corresponding Author: Debora Esposito, Plants for Human Health Institute, Department of Animal Science, North Carolina State University, Kannapolis, United States of America.

Received: November 15, 2019; Published: December 11, 2019



  This work evaluated the phytochemical composition of freeze-dried acerola, camu-camu, apple and pineapple extracts, and correlated it with their cell-based in vitro antioxidant, anti-inflammatory and wound healing activities. All freeze-dried fruit extracts at 50 µm/mL significantly inhibited (p<0.001) reactive oxygen species (ROS) up to 70%, but only acerola and camu-camu extracts at 150 µm/mL decreased (p<0.001) the nitric oxide (NO) production (up to 33%) in LPS-stimulated RAW 264.7 macrophages. When selected mRNA biomarkers of acute inflammation were evaluated, all freeze-dried fruit extracts inhibited the expression of IL-6 and IL-1β genes, but only acerola reduced the COX-2 expression (p<0.01). In addition, freeze-dried acerola extract (50 µm/mL) significantly enhanced human dermal fibroblasts (HDFa) migration by 1.5-fold compared to the control after 36 h. Based on our results, we hypothesize that the high concentration of ascorbic acid (9454.3 mg/100 g) and anthocyanin contents (14.0 mg /100 g) of freeze-dried acerola may play an important role on the in vitro biological results.

Keywords: Ascorbic Acid; Inflammation; Acerola; Wound Healing; Edible Fruits



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Citation: Debora Esposito.,et al. “Phytochemical Content, Antioxidant, Anti-inflammatory Activities and Wound Healing Properties of Freeze-Dried Fruits".Acta Scientific Nutritional Health 4.1 (2020): 63-71.


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