Enno Christian Kurt Freye1,2* and Hans -Peter Strobel1
1Department of Galenics, Energy Development, Switzerland
2The University of Duesseldorf, Germany
*Corresponding Author: Enno Christian Kurt Freye, Department of Galenics, Energy Development, Switzerland and the University of Duesseldorf, Germany.
Received: April 17, 2018; Published: June 05, 2018
Citation: Enno Christian Kurt Freye and Hans -Peter Strobel. “Coenzyme Q10 Supplements which Increase ATP Synthesis within Mitochondria and Protect Against Toxic Sodium Azide”. Acta Scientific Nutritional Health 2.7 (2018).
Objectives: Numerous CoQ10 preparations are on the market of which however, very little is known about their bioavailability and most of all there is no information regarding their efficacy on the mitochondrial electron transport chain (ETC), being the prime driver for ATP synthesis.
Methods: Various CoQ10 formulations on the market were analyzed in regard to their ingredients to boost bioavailability but also their efficacy on the synthesis of ATP formation within the mitochondria as outlined in publications. Own experiments in young healthy volunteers were given two CoQ10 supplements over a period of 5 weeks, while ATP concentration was measured in granulocytes before and after, using bioluminescence luciferase probes. In addition, the vitality of mitochondria following inhibition with sodium azide and the recovery rate after wash-out was also determined.
Results: Numerous CoQ10 formulation, in spite of their high bioavailability, however, lack any kind of conclusive data demonstrating an increase in ATP formation, a necessary constituent in the overall function of cells. In addition, the touted higher efficacy of ubiquinol when compared to ubiquinone, is nowhere demonstrated sufficiently. In contrast, ingredients within certain ubiquinol formulations do contain toxic substances for the sake to increase bioavailability, however, having a toxic effect on mitochondria. Two Q10 formulations (Grreenspeed® and Q10 Revolution®) aside from their high bioavailability, at the same time also increase the formation of ATP within the mitochondria and very likely also protect these master organelles from toxic substances of the environment, where sodium azide was used as a toxic inhibitor.
Conclusion: So far two CoQ10 preparations (Q10 Revolution® and Greenspeed®) on the European market demonstrate sufficient bioavailability while at the same time also have a significant effect on ATP synthesis within mitochondria. These Q10 compounds to a certain degree, may even work as protective agents against toxicity induced by the polluted environment.
Keywords: CoQ10; Q10 Formulation; Bioavailability; ATP Synthesis; Greenspeed®; Q10 Revolution®; Mitochondrial Recovery
Copyright: © 2018 Enno Christian Kurt Freye and Hans -Peter Strobel. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.