Acta Scientific Nutritional Health

Research ArticleVolume 2 Issue 3

Investigation of Histopathological Effect of Piper nigrum Consumption on Selected Organ of Male Wistar Rats

Nosa Terry Omorodion1* and Wilson Ogbonna Ajanwachuku2

1Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, University of Nigeria, Enugu campus, Enugu, Nigeria
2Health Services Department, Ugbowo, University of Benin, Benin city, Edo State, Nigeria

*Corresponding Author: Nosa Terry Omorodion, Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, University of Nigeria, Enugu campus, Enugu, Nigeria.

Received: December 27, 2017; Published: February 02, 2018

Citation: Nosa Terry Omorodion and Wilson Ogbonna Ajanwachuku. “Investigation of Histopathological Effect of Piper nigrum Consumption on Selected Organ of Male Wistar Rats”. Acta Scientific Nutritional Health 2.3 (2018).

Abstract

  Piper nigrum (Black pepper) plant is a flowering woody perennial climbing vine that belongs to Piperaceae family. Pepper plants easily grow in the shade on supporting trees, trellises or poles up to a maximum height of 13 feet or 4 meters and roots may come out from leaf nodes if vine touches the ground. The plants have heart shape alternate leaves with typically large size of 5 - 10 cm in length and 3 - 6 cm across, with 5 to 7 prominent palmate veins. The flowers are small, monoecious with separate male and female flowers but may be polygamous which contain both male and female flowers. Piper species significantly inhibited the atherogenic diet induced increased lipid profile and alteration in antioxidant enzymes activities. The micrograph of the kidney sections in control group I showed normal histological cytoarchitecture with well-defined glomeruli. However, at 4 weeks of black pepper administration, cellular infiltration and severe lobulated and distorted glomeruli were observed in rat fed 0.62 ml, also at the 6th weeks of black pepper glomeruli shrinkage was seen. Conclusively, it could be inferred from the findings that black pepper administration can cause architectural distortions as evident in the kidneys, liver and testes sections above.

Keywords: Piper nigrum; Histopathological; Liver; Testes

Copyright: © 2018 Nosa Terry Omorodion and Wilson Ogbonna Ajanwachuku. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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