Dendrimer Coated SPIONs: Synthesis, Characterization and Potentials in Biomedical Applications
Navjeet Kaur B Lotey1,2*, Ramesh Chaughule2 and Suhas Pednekar3
1National Center for Nanoscience and Nanotechnology, University of Mumbai, India
2Ramnarain Ruia Autonomous College, India
3Vice Chancellor, University of Mumbai, India
*Corresponding Author: Navjeet Kaur B Lotey, Assistant Professor, National Center for Nanoscience and Nanotechnology, Vidyanagari Campus, University of Mumbai, Mumbai, Maharashtra, India.
July 12, 2022; Published: July 28, 2022
The study focuses on the synthesis, characterization and potential applications of hybrid nanoparticles - dendrimer coated super paramagnetic iron oxide nanoparticles. Hybrid nanoparticles are usually superior in properties as compared to their individual components. Herein, we have made use of superparamagnetic inorganic component with a special class of polymeric organic component. Their synthesis and characterization techniques have been described in this study using methods like XRD, SEM, TEM, FTIR and VSM. Further, their properties have been evaluated using MTT assay and dye loading studies. In conclusion, dendrimer coated super paramagnetic iron oxide nanoparticles prove to be a better choice in order to enhance multifunctionality, biocompatibility while also retaining magnetic responsiveness and other advantages of inorganic materials. Overall, such kind of stable and readily customizable structures are promising tools in the future of biomedicine for applications in imaging, drug delivery, theranostics and cancer therapy.
Keywords: Dendrimers; SPIONs; Magnetic Nanoparticles; Hybrid Nanoparticles; Drug Delivery; Biomedicine; Theranostics
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