Anita Kant¹, Amrita Razdan Kaul²*, Usha Priyambada² and Esha Modi³

¹Chairman OBG Services, Department of Obstetrics and Gynecoloogy, Asian Institute of Medical Sciences, Faridabad, India
²Senior Consultant, Asian Institute of Medical Sciences, Faridabad, India
³Senior Resident, Asian Institute of Medical Sciences, Faridabad, India

*Corresponding Author: Amrita Razdan Kaul, Senior Resident, Asian Institute of Medical Sciences, Faridabad, India.

Received: November 02, 2025; Published: November 20, 2025

Abstract

Introduction: GDM is reduced glucose tolerance resulting in varied degree of hyperglycemia developing or being recognized first during pregnancy, one of the complications of pregnancy posing not only immediate risk to mother and fetus but also long-term health implications to both.

Compared to European women, south Asian especially Indian females have 11 times increased risk of GDM. However screening and diagnostic tests for GDM are implemented between 24-28 week of gestation resulting in effective loss of period in which insulin resistance secondary to diabetogenic hormones from placenta already initiate metabolic changes leading to adverse fetal and maternal outcome. Association between elevated uric acid levels and adverse pregnancy outcomes like hypertensive disorders of pregnancy, fetal growth restriction is well established however whether hyperuricemia contributes directly to the risk of diabetes millites remains largely observational and inconclusive. Elevated uric acid can act as both as a biomarker and a potential mediator of metabolic mis regulation during pregnancy.

Objective: Aim of this study was to determine whether elevated uric acid levels in first trimester can serve as a warning signal for development of GDM later in pregnancy thus facilitating timely preventive intervention.

Materials and Methods: This is hospital based prospective observational study, conducted on 200 low-risk pregnant women attending outpatient department of OBG services, AIMS, Faridabad, Haryana over a period of 2 years.

With ethical clearance and patient’s consent uric acid levels are obtained in low risk pregnant females of less than 13 weeks gestation. Same patients underwent DIPSI test between 24 to 28 weeks of gestation. Regression analysis employing receiver operating characteristic (ROC) curves and logistic regression was used to evaluate predictability of serum uric acid levels in first trimester for GDM in later part of the pregnancy.

Result: For GDM prediction serum uric acid levels and DIPSI values show strong positive correlation (Pearson correlation coefficient 0.750, p = 0.0001). Conclusion: Elevated serum uric acid levels in first trimester of low risk pregnant females can be considered as independent predictor of GDM later in pregnancy.

Keywords: Gestational Diabetes Mellitus (GDM); Uric Acid

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Citation

Citation: Amrita Razdan Kaul., et al. “To Evaluate the Predictive Value of Serum Uric Acid Levels in First Trimester for Risk of GDM Later in Low Risk Pregnant Women". Acta Scientific Women's Health 7.12 (2025): 08-13.

Copyright

Copyright: © 2025 Amrita Razdan Kaul., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.