David Ghozland*, Ericka Herrera

Department of Obstetrics and Gynaecology

*Corresponding Author: David Ghozland, Department of Obstetrics and Gynaecology.

Received: August 11, 2024; Published: August 30, 2025

Abstract

Background: Postoperative pain, edema, and ecchymosis are common challenges following labiaplasty, potentially prolonging recovery. This study evaluates a multimodal enhanced recovery protocol incorporating topical peptides (BPC‑157, GHK‑Cu), carboxytherapy, topical estradiol, and autologous platelet-rich plasma (PRP) to assess effects on postoperative outcomes.

Methods: Retrospective review of 10 consecutive patients undergoing labiaplasty from April 25–September 1, 2025. Protocol included: (1) BPC‑157 + GHK‑Cu cream BID, (2) nightly transcutaneous carboxytherapy x3 days, (3) topical estradiol x14 days, (4) intraoperative PRP with repeat at 4 weeks. Outcomes included postoperative pain (VAS), swelling (graded photographs), ecchymosis, healing time, and patient satisfaction, compared to historical controls.

Results: The enhanced recovery cohort showed a 20% reduction in swelling, 30% lower VAS pain scores (p < 0.05), 2-day earlier bruising resolution, and faster return to baseline activity (11 vs. 14 days). No adverse events were observed. Patient satisfaction improved, with 90% rating recovery as “excellent”.

Conclusion: This multimodal protocol utilizing regenerative peptides, estrogen support, PRP, and carboxytherapy accelerated recovery after labiaplasty. Findings support further investigation in prospective controlled trials.

Keywords: Labiaplasty; Ecchymosis; Healing Time

References

Citation

Citation: David Ghozland., et al. “Enhanced Recovery Protocol Using Peptide Therapy, PRP, Carboxytherapy, and Estradiol for Labiaplasty: A Retrospective Observational Study". Acta Scientific Women's Health 7.9 (2025): 33-35.

Copyright

Copyright: © 2025 David Ghozland., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.