Susmita Debnath¹, Pabitra Debnath², Sabrina Shafiq³, Khan Md Shahariar Zaman³, Sheuly Ferdousi⁴, Rokshana Begum⁵, Shaikh Badiuzzaman³ and Mesbah Uddin Ahmed⁶*

¹Medical Officer, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University, Bangladesh
²Medical Officer, Department of Radiology and Imaging, Bangabandhu Sheikh Mujib Medical University, Bangladesh
³Assistant Professor, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University, Bangladesh
⁴Associate Professor, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University, Bangladesh
⁵Consultant, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University, Bangladesh
⁶Chief Medical Technologist, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University, Bangladesh

*Corresponding Author: Mesbah Uddin Ahmed, Chief Medical Technologist, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University, Bangladesh.

Received: June 06, 2025; Published: June 17, 2025

Abstract

This research explores the potential of urinary 8-OHdG as a biomarker for early cancer detection and risk estimation. It aims to understand its correlation with breast cancer risk and its predictive value. The findings could contribute to developing non-invasive, cost-effective methods for early detection and risk stratification. The study investigated the potential of urine 8-OHdG as a method for early breast cancer risk assessment and diagnosis. Thirty participants were selected from Bangladesh Medical University, Dhaka, and their urine samples were collected by maintaining proper way and data were analyzed by SPSS version 27. Ethical issues were prioritized, with participants provided counseling and written informed consent. The study explores the relationship between uri nary 8-OHdG levels and various breast cancer tumors, clinical parameters, and prognosis. The cohort is predominantly women, with a mean age of 48.7 years. Urinary 8-OHdG levels are associated with risk factors like oestrogen replacement therapy, obesity, post menopausal state, and multiparity. Larger levels are linked to higher histological grades and positive lymph node involvement. The results suggest urine 8-OHdG's potential as a biomarker for breast cancer.

Keywords: Urinary 8-OHdG; Potential Tool; Early Detection; Risk Estimation; Breast Carcinoma

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Citation

Citation: Mesbah Uddin Ahmed., et al “Urinary 8-OHdG: A Potential Tool for Early Detection and Risk Estimation in Breast Carcinoma". Acta Scientific Women's Health 7.7 (2025): 08-12.

Copyright

Copyright: © 2025 Mesbah Uddin Ahmed., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.