Acta Scientific Women's Health

Case Report Volume 7 Issue 2

Cornual Invasive Mole: A Diagnostic and Therapeutic Challenge

Armando Menocal1, Rocio Santin2, Ramiro Cabrera3, César Aguilar2*, Steicy Flores4, Dayana Piedra4, Lucia Chaul3, Jhanneth Chura3 and Alvaro J Ovando3

1Head of Gynecologic Minimally Invasive Surgery, Hospital de la Mujer de Morelia, México
2Attending Physcian, Gynecology Departament, Hospital de la Mujer de Morelia, México
3Minimally Invasive Gynecology Surgery, Instituto Doyenne, México
4Gynecologic Fellow, Hospital de la Mujer de Morelia, México

*Corresponding Author: César Aguilar, Attending Physcian, Gynecology Departament, Hospital de la Mujer de Morelia, México.

Received: January 22, 2025; Published: January 31, 2025

Abstract

Introduction: Gestational trophoblastic disease in the cornual invasive mole variant is a rare condition, representing a diagnostic challenge, typically evolving from a complete hydatiform mole.

Material and Methods: The following clinical case presents 25 years old primigravida referred with history of uterine aspiration two months prior due to a complete hydatiform mole and persistent HCG levels despite undergoing one dose of methotrexate.

In our institution at the evaluation whit a suspicious of cornual invasive mole. A Surgical treatment is planned. A hysteroscopy and laparoscopy are performed, which confirm persistent molar tissue in the right uterine horn. Surgical management included temporary vascular control through uterine artery ligation an vasopressin use, followed by excision of the molar tissue. The final histological report confirmed the diagnosis of invasive mole.

Discussion: The development of cornual invasive mole is poorly understood, however surgical management combined with chemotherapeutic treatment significantly reduces the risk of metastasis. In this case the use of minimally invasive techniques allowed precise resection of the molar tissue while preserving fertility in a woman of reproductive age.

Keywords: Invasive Mole; Cornual Pregnancy; Hysteroscopy; Fertility Preservation; Minimally Invasive Surgery

References

  1. Ning Fen. "Understanding and Management of Gestational Trophoblastic Disease”. F1000 Research 8 (2019): 428.
  2. Qian Jing., et al. "Cornual Invasive Hydatidiform Mole: A Rare Case Report and Literature Review”. BMC Women's Health 566 (2023).
  3. Coronado Pluvio J. “Practical Care Guide. Gestational Trophoblastic Disease”. Spanish Society of Gynecology and Obstetrics, Progress in Obstetrics and Gynecology3 (2020): 165-184.
  4. Qian Jing., et al. "Cornual Invasive Hydatidiform Mole: A Rare Case Report and Literature Review”. BMC Women's Health566 (2023).
  5. Si Manfei. "An Unexpected Invasive Hydatidiform Mole in a Rudimentary Uterine Horn: A Case Report”. Oncology Letters3 (2017): 2808-2812.
  6. Lukinovic Nusa. "Advances in Diagnostics and Management of Gestational Trophoblastic Disease”. Radiology and Oncology4 (2022): 430-439.
  7. Giorgione V., et al. "Role of Surgery in the Management of Hydatidiform Mole in Elderly Patients: A Single-Center Clinical Experience”. International Journal of Gynecological Cancer 27.3 (2017): 550-553.
  8. Horowitz NS. "Epidemiology, Diagnosis, and Treatment of Gestational Trophoblastic Disease: A Society of Gynecologic Oncology Evidence-Based Review and Recommendation”. Gynecologic Oncology 163 (2021): 605-613.
  9. Xu Linjuan. "Case Report: Conservative Treatment for Fertility Preservation in a Woman with Hemoperitoneum Due to an Invasive Mole”. Frontiers in Oncology 12 (2022).
  10. , et al. "Total Hysterectomy versus Uterine Evacuation for Preventing Post-Molar Gestational Trophoblastic Neoplasia in Patients Who Are at Least 40 Years Old: A Systematic Review and Meta-Analysis”. BMC Cancer 19.13 (2019).

Citation

Citation: César Aguilar., et al. “Cornual Invasive Mole: A Diagnostic and Therapeutic Challenge".Acta Scientific Women's Health 7.2 (2025): 31-34.

Copyright

Copyright: © 2025 César Aguilar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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