Acta Scientific Dental Sciences

Review Article Volume 7 Issue 1

The Long-term Rate of Repeat Surgery After Optimal Excision Surgery of Endometriosis at a Single Tertiary Referral Center

Patrick Yeung*, Ayesha Mohan and Jeffrey A Gavard

Saint Louis University, USA

*Corresponding Author: Patrick Yeung, RESTORE Center for Endometriosis, Founder and Owner, Adjunct Professor, Saint Louis University, USA.

Received: December 09, 2024; Published: December 18, 2024

Abstract

The primary purpose of this prospective cohort study was to determine if treating endometriosis with optimal excision surgery leads to lower rates of repeat surgery as compared to historical rates of repeat surgery by ablation. A secondary outcome was to ex amine whether the use of hormonal suppression differed before surgery, depending on the stage of endometriosis found at surgery. Optimal excision was defined as completely excising all areas of abnormal peritoneum, wherever found in the pelvis, having looked systematically with near contact laparoscopy. All surgeries were performed by a single surgeon specializing in optimal excision at a tertiary referral center. The rate of repeat surgery after optimal excision surgery for endometriosis was remarkably low (2.5%, 15/620) as compared to historical rates of repeat surgery by ablation. Additionally, the lack of significant evidence between hor monal suppression use and progression of stage of endometriosis provides implicit evidence that hormonal suppression does not prevent progression of the disease. Further controlled studies are needed to verify these findings.

Keywords: Endometriosis; Excision Surgery; Hormonal Suppression; Repeat Surgery; Second-Look Surgery

References

  1. Nirgianakis K., et al. “Recurrence Patterns after Surgery in Patients with Different Endometriosis Subtypes: A Long-Term Hospital-Based Cohort Study”. Journal of Clinical Medicine (2020): 9.
  2. Chen I., et al. “Pre- and postsurgical medical therapy for endometriosis surgery”. Cochrane Database of Systematic Reviews 11 (2020): CD003678.
  3. Greene AD., et al. “Endometriosis: where are we and where are we going?” Reproduction 152 (2016): R63-R78.
  4. Hart RJ., et al. “Excisional surgery versus ablative surgery for ovarian endometriomata”. Cochrane Database of Systematic Reviews (2008): CD00499.
  5. Yeung P Jr., et al. “A pilot feasibility multicenter study of patients after excision of endometriosis”. JSLS 17 (2013): 88-94.
  6. Takenaka M., et al. “Exploratory study of pre-surgical medications with dienogest or leuprorelin in laparoscopic cystectomy of endometrial cysts”. Journal of Obstetrics and Gynaecology Research 41 (2015): 1234-1239.
  7. Sutton CJ., et al. “Prospective, randomized, double-blind, controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild, and moderate endometriosis”. Fertility and Sterility 62 (1994): 696-700.
  8. Alkatout I., et al. “Combined surgical and hormone therapy for endometriosis is the most effective treatment: prospective, randomized, controlled trial”. Journal of Minimally Invasive Gynecology 20 (2013): 473-481.
  9. Bozdag G. “Recurrence of endometriosis: risk factors, mechanisms and biomarkers”. Womens Health (Lond) 11 (2015): 693-699.
  10. Carmona F., et al. “Ovarian cystectomy versus laser vaporization in the treatment of ovarian endometriomas: a randomized clinical trial with a five-year follow-up”. Fertility and Sterility 96 (2011): 251-254.
  11. Rafique S and Decherney AH. “Medical Management of Endometriosis”. Clinical Obstetrics and Gynecology 60 (2017): 485-496.
  12. Zondervan KT., et al. “Endometriosis”. The New England Journal of Medicine 382 (2020): 1244-1256.
  13. Sørensen SS., et al. “Pre- and postoperative therapy with GnRH agonist for endometrial resection. A prospective, randomized study”. Acta Obstetricia et Gynecologica Scandinavica 76 (1997): 340-344.
  14. Rana N., et al. “Decrease in the size of ovarian endometriomas during ovarian suppression in stage IV endometriosis. Role of preoperative medical treatment”. Journal of Reproduction Medicine 41 (1996): 384-392.
  15. Healey M., et al. “To excise or ablate endometriosis? A prospective randomized double-blinded trial after 5-year follow-up”. Journal of Minimally Invasive Gynecology 21 (2014): 999-1004.
  16. Bignardi T., et al. “Excisional versus ablative surgery for peritoneal endometriosis”. Cochrane Database of Systematic Reviews 2019 (2019): CD008979.
  17. Fincham, JE. “Response rates and responsiveness for surveys, standards, and the Journal”. American Journal of Pharmaceutical Education 72 (2008): 43.
  18. Stratton P and Berkley KJ. “Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications”. Human Reproduction Update 17 (2011): 327-346.
  19. Yap C., et al. “Pre and post operative medical therapy for endometriosis surgery”. Cochrane Database of Systematic Reviews 2004 (2004): CD003678.
  20. Pecorino B., et al. “Progression Free Survival, Overall Survival, and Relapse Rate in Endometrioid Ovarian Cancer and Synchronous Endometrial-Ovarian Endometrioid Cancer (SEO-EC): Results from a Large Retrospective Analysis”. Medicina (Kaunas) 58 (2022): 1706.
  21. Martire FG., et al. “Early noninvasive diagnosis of endometriosis: dysmenorrhea and specific ultrasound findings are important indicators in young women”. Fertility and Sterility 119 (2023): 455-464.
  22. Millischer AE., et al. “Adolescent endometriosis: prevalence increases with age on magnetic resonance imaging scan”. Fertility and Sterility 119 (2023): 626-633.

Citation

Citation: Patrick Yeung., et al. “The Long-term Rate of Repeat Surgery After Optimal Excision Surgery of Endometriosis at a Single Tertiary Referral Center". Acta Scientific Dental Sciences 7.1 (2025): 03-12.

Copyright

Copyright: © 2025 Patrick Yeung., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days

Indexed In





News and Events


  • Reviewer Certificate
    Certificate will be issues to the valued reviewer who worked on the Articles Peer Review process.
  • Publication Certificate
    Authors will be provided with the Publication Certificate after their successful publication
  • Last Date for submission
    Authors are requested to submit their manuscripts before September 30, 2025

Contact US